Heterocyclization Reactions of Pyruvic Acids and Aminoazoles with Controlled Chemoselectivity

The present review includes the analysis of known literature data concerning linear and multicomponent heterocyclizations involving pyruvic acids and aminoazoles. In particular, the review demonstrates the approaches to control regio- and chemoselectivity of these types of treatments and their application to solve the matters of Diversity Oriented Synthesis

Aminoazole-Based Diversity-Oriented Synthesis of Heterocycles

The comprehensive review contains the analysis of literature data concerning reactions of heterocyclization of aminoazoles and demonstrates the application of these types of transformations in diversity-oriented synthesis. The review is oriented to wide range of chemists working in the field of organic synthesis and both experimental and theoretical studies of nitrogen-containing heterocycles

The Poetry of Aleksandrs Čaks in the Russian Language.

Bakalaura darbs ir veltīts latviešu autoru darbu rakstīšanas krievu valodā fenomenam, kā arī latviešu un krievu literatūras sakaru izpētei. Autore aplūko Aleksandra Čaka krievu valodā rakstītās dzejas publicēšanas vēsturi – pētījumā pirmo reizi tiek veikta Aleksandra Čaka darbu analīze krievu valodā. Aleksandra Čaka krievu dzejoļu analīze tiek veikta, balstoties iz viņa biogrāfijas faktiem un, ņemot vērā modernisma dzejas principus. Pētījums var ieinteresēt filologus, kuri nodarbojas ar līdzīgu problemātiku, ka arī visus lasītājus, kas interesējas par rakstības citā valodā fenomenu.The Diploma paper is devoted to the research of the phenomenon of writing works by Latvian authors in Russian, as well as to the research of the Latvian-Russian literary relations in the texts of Aleksandrs Chaks.. The author analyzes Alexander Chuck's work in a foreign language. The Diploma work is an analysis of Aleksandrs Chaks's poems and his biography. Based on the analysis, the phenomenon of writing Russian works by a Latvian author, in this case Aleksandrs Chaks, is proved. The present research can be interesting to philologists who are engaged into the similar studies, as well as to all types of readers who are interested in the discussed issue

Neurobiological Highlights of Cognitive Impairment in Psychiatric Disorders

This review is focused on several psychiatric disorders in which cognitive impairment is a major component of the disease, influencing life quality. There are plenty of data proving that cognitive impairment accompanies and even underlies some psychiatric disorders. In addition, sources provide information on the biological background of cognitive problems associated with mental illness. This scientific review aims to summarize the current knowledge about neurobiological mechanisms of cognitive impairment in people with schizophrenia, depression, mild cognitive impairment and dementia (including Alzheimer’s disease).The review provides data about the prevalence of cognitive impairment in people with mental illness and associated biological markers

A high‐fat diet changes astrocytic metabolism to promote synaptic plasticity and behavior

Aim: A high-fat diet (HFD) is generally considered to negatively influence the body, the brain, and cognition. Nonetheless, fat and fatty acids are essential for nourishing and constructing brain tissue. Astrocytes are central for lipolysis and fatty acids metabolism. We tested how HFD affects astrocyte metabolism, morphology, and physiology. Methods: We used Raman microspectroscopy to assess the redox state of mitochondria and lipid content in astrocytes and neurons in hippocampal slices of mice subjected to HFD. Astrocytes were loaded with fluorescent dye through patch pipette for morphological analysis. Whole-cell voltage-clamp recordings were performed to measure transporter and potassium currents. Western blot analysis quantified the expression of astrocyte-specific proteins. Field potential recordings measured the magnitude of long-term potentiation (LTP). Open filed test was performed to evaluate the effect of HFD on animal behavior. Results: We found that exposure of young mice to 1 month of HFD increases lipid content and relative amount of reduced cytochromes in astrocytes but not in neurons. Metabolic changes were paralleled with an enlargement of astrocytic territorial domains due to an increased outgrowth of branches and leaflets. Astrocyte remodeling was associated with an increase in expression of ezrin and with no changes in glial fibrillary acidic protein (GFAP), glutamate transporter-1 (GLT-1), and glutamine synthetase (GS). Such physiological (non-reactive) enlargement of astrocytes in the brain active milieu promoted glutamate clearance and LTP and translated into behavioral changes. Conclusion: Dietary fat intake is not invariably harmful and might exert beneficial effects depending on the biological context.</p

Positive Effect of Cognitive Training in Older Adults with Different APOE Genotypes and COVID-19 History: A 1-Year Follow-Up Cohort Study

(1) Background: Older people suffer from cognitive decline; several risk factors contribute to greater cognitive decline. We used acquired (COVID-19 infection) and non-modifiable (presence of APOE rs429358 and rs7412 polymorphisms) factors to study the progression of subjective cognitive impairment while observing patients for one year. Cognitive training was used as a protective factor. (2) Methods: Two groups of subjects over the age of 65 participated in the study: group with subjective cognitive decline receiving cognitive training and individuals who did not complain of cognitive decline without receiving cognitive training (comparison group). On the first visit, the concentration of antibodies to COVID-19 and APOE genotype was measured. At the first and last point (1 year later) the Mini-Mental State Examination scale and the Hospital Anxiety and Depression Scale were performed. (3) Results: COVID-19 infection did not affect cognitive function. A significant role of cognitive training in improving cognitive functions was revealed. Older adults with APOE-&epsilon;4 genotype showed no positive effect of cognitive training. (4) Conclusions: Future research should focus on cognitive dysfunction after COVID-19 in long-term follow-up. Attention to the factors discussed in our article, but not limited to them, are useful for a personalized approach to maintaining the cognitive health of older adults