Are patients and relatives the better innovators? The case of medical smartphone applications

Prior research has shown that users are a valuable resource for identifying new product or service innovations. However, few scholars have analyzed how different user types such as intermediate and end users are interacting along the value chain of an emerging new product and how they contribute to innovation. Further, user innovation success in the market is often unclear, since very few innovations diffuse directly to customers from the user innovators. We analyze different innovative contributions of intermediate and end users that have been sold and evaluated within the healthcare sector. Several studies in the healthcare sector have shown that healthcare professionals are an important source of innovation. Yet, to date, companies and scholars have paid little attention to the end users of medical devices: patients. We focus on the innovative behavior of patients and their relatives, their motivations, and their contributions to improving the quality of their own and ultimately of other patients' therapy. We analyze innovations of producers, healthcare professionals, patients, and relatives in the German, UK, and U.S. markets for medical smartphone apps (Apple App Store) and conduct 16 semi-structured interviews. Our findings show that users develop around 46% of all medical smartphone applications (apps). We analyzed 510,229 user ratings and found that apps designed by patients, relatives, and healthcare professionals are rated significantly better by App Store customers than apps created by professional software companies. Apps developed by patients' relatives achieve significantly more downloads and generate on average three times higher revenues per year. The initial medical smartphone app developments in the early days of the Apple App Store were mainly triggered by healthcare professionals. The interview data shows the extensive medical knowledge of patients and their relatives, particularly those with chronic diseases. The overall findings are in line with a current literature stream that indicates that patients are gaining more influence on their treatment, are better informed, and are taking more actions to increase their quality of life. Commercial healthcare companies should take advantage of this and should consider including patients and relatives into their product development

Berlin-Pankow Flora-Apotheke

<p>Historical questionnaire/s 1924/1948 and index cards, partly selected enclosures regarding the history of a</p><p>German pharmacy, catalogued via Kalliope portal (Historischer Fragebogen 1924/1948 und Karteikarten, ggf.</p><p>gemeinfreie Anlagen zur Apothekengeschichte; als Katalog dient das Nachlassportal Kalliope):</p><p>https://kalliope-verbund.info/DE-611-BF-70963</p><p>[Funktion: Im Findbuch anzeigen]</p><p> </p><p>Please note: The Kalliope catalogue entry might indicate related material in the archival folder which cannot</p><p>be published due to copyright or other legal restrictions (NB: Das Katalogisat bei Kalliope kann auch auf</p><p>Materialien - teils erheblichen Umfangs - verweisen, die aus archiv- oder urheberrechtlichen Gründen nicht</p><p>veröffentlicht werden dürfen).</p&gt

Lead user method vs. innovation contest: An empirical comparison of two open innovation methodologies for identifying social innovation for flood Resilience in Indonesia

Organizations in the humanitarian sector often face problems that are hard to solve owing to their complexity and high hidden solution knowledge. We investigate two problem-solving governance mechanisms in the case of floods in Indonesia. In our study, we compare the costs and benefits of two open innovation tools for identifying social innovation: an innovation contest and the lead user method. An innovation contest is a challenge among participants, who submit potential solutions to a problem that is posted in an open call. In contrast, the lead user method is a structured search process to identify innovators who have already developed solutions for their own needs or those of their peers. While innovation contests have seen significant attention, there is very little evidence that the lead user method is a suitable tool to identify social innovation. In our study, the contest yielded more than twice as much submissions as the lead user method (60 vs. 25). Our analysis reveals that concepts obtained by the lead user method score significantly higher in overall quality as well as regarding use value, feasibility, degree of elaboration, and social impact. The concepts' novelty do not significantly differ between the two groups. We discuss these findings against the background of the humanitarian sector being torn between capacity overload and the need to overcome a one-size-fits-all approach. By transferring two recognized governance forms for innovation identification from the private sector to the humanitarian sector, we introduce a new path towards empowering local innovators to solve humanitarian challenges

Looking for a needle in a haystack - How to search for bottom-up social innovations that solve complex humanitarian problems

The worldwide increase in societal challenges is putting pressure on humanitarian organizations to develop sophisticated approaches to leverage social innovations in the humanitarian sector. Since humanitarian problems are complex problems, with the relevant knowledge being hidden, organizational search theory advocates the application of bottom-up and theory-guided search processes to identify the social innovations that solve these. Unfortunately, there has been no theoretical attention to understanding which approaches apply in this context. Further, established theory-guided bottom-up search processes, such as the lead user method, are unsuitable to the humanitarian sector, and we lack practice examples of adequate search processes. To start addressing this gap in theory and practice, procedural action research was done with the International Federation of Red Cross and Red Crescent Societies to develop a theory-guided bottom-up innovation search process for the real-life humanitarian problem of recurring floods in Indonesia. It revealed that an innovation search process for this context must differ significantly concerning its objectives and the steps to be taken from the lead user method, which was used as a starting point. Further, a comparison of the technical quality and the social impacts of the identified social innovations with social innovations identified through a non-theory-guided bottom-up search process (i.e. an innovation contest) suggests the superiority of this theory-guided search process. With this conclusion and the insights derived throughout the development of the search process, this study makes important contributions to theory development in the social and open innovation literatures and delivers important recommendations for social innovation practice in the humanitarian sector

Biodegradable poly (lactic acid-co-glycolic acid) scaffolds as carriers for geneticallymodified fibroblasts

Recent advances in gene delivery into cells allow improved therapeutic effects in gene therapy trials. To increase the bioavailability of applied cells, it is of great interest that transfected cells remain at the application site and systemic spread is minimized. In this study, we tested clinically used biodegradable poly(lactic acid-co-glycolic acid) (PLGA) scaffolds (Vicryl & Ethisorb) as transient carriers for genetically modified cells. To this aim, we used human fibroblasts and examined attachment and proliferation of untransfected cells on the scaffolds in vitro, as well as the mechanical properties of the scaffolds at four time points (1, 3, 6 and 9 days) of cultivation. Furthermore, the adherence of cells transfected with green fluorescent protein (GFP) and vascular endothelial growth factor (VEGF165) and also VEGF165 protein secretion were investigated. Our results show that human fibroblasts adhere on both types of PLGA scaffolds. However, proliferation and transgene expression capacity were higher on Ethisorb scaffolds most probably due to a different architecture of the scaffold. Additionally, cultivation of the cells on the scaffolds did not alter their biomechanical properties. The results of this investigation could be potentially exploited in therapeutic regiments with areal delivery of transiently transfected cells and may open the way for a variety of applications of cell-based gene therapy, tissue engineering and regenerative medicine