Formation of the Terrestrial Planets from a Narrow Annulus

We show that the assembly of the Solar System terrestrial planets can be successfully modelled with all of the mass initially confined to a narrow annulus between 0.7 and 1.0 AU. With this configuration, analogues of Mercury and Mars often form from the collisional evolution of material diffusing out of the annulus under the scattering of the forming Earth and Venus analogues. The final systems also possess eccentricities and inclinations that match the observations, without recourse to dynamical friction from remnant small body populations. Finally, the characteristic assembly timescale for Earth analogues is rapid in this model, and consistent with cosmochemical models based on the $^{182}$Hf--$^{182}$W isotopes. The agreement between this model and the observations suggests that terrestrial planet systems may also be formed in `planet traps', as has been proposed recently for the cores of giant planets in our solar system and others.Comment: 37 pages, 16 figures. to appear in Ap

Analysis of composite wing structures with a morphing leading edge

One of the main challenges for the civil aviation industry is the reduction of its environmental impact. Over the past years, improvements in performance efficiency have been achieved by simplifying the design of the structural components and using composite materials to reduce the overall weight. These approaches however, are not sufficient to meet the current demanding requirements set for a „greener‟ aircraft. Significant changes in drag reduction and fuel consumption can be obtained by using new technologies, such as smart morphing structures. These concepts will in fact help flow laminarisation, which will increase the lift to drag ratio. Furthermore, the capability to adapt the wing shape will enable to optimise the aerodynamic performance not only for a single flight condition but during the entire mission. This will significantly improve the aircraft efficiency. The current research work has been carried out as part of the European Commission founded Seventh Framework Program called „Smart High Lift Device for the Next Generation Wing‟ (SADE), which main aim is to develop and study morphing high lift devices. The author‟s investigation focused on developing a design concept for the actuation mechanism of a morphing leading edge device. A detailed structural analysis has been carried out in order to demonstrate its feasibility.In the first phase of the research the attention was directed on the preliminary design and analysis of the composite wing box. The parameters of the key structural components, such as skin, spars, ribs and stringers were set to satisfy the static stress and buckling requirements. Moreover, numerical and experimental studies were conducted to analyse the static failure and buckling behaviour of two typical composite wing structural components: a spar section and a web and base joint assembly. In the second stage of the research, a design for the morphing leading edge actuation mechanism was developed. The actuation system was designed in such a way that the target shape was reached with minimum actuation force demand. A geometrical nonlinear FE analysis was conducted to simulate the leading edge morphing deflection and ensure that structural strength requirements were satisfied. Furthermore, the behaviour of the skin integrated with the internal actuation mechanism was modelled under the aerodynamic pressure, at different flight conditions and gust loads, in order to prove that the proposed actuation system can compete with the conventional rigid rib. This study demonstrated that a feasible morphing leading edge design for a next generation large aircraft wing can be achieved. Developing the readiness of this technology will have a significant impact on aircraft efficiency and considerable contribution towards a more environmental friendly aviation.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Aggregation number distributions and mesoglobules in dilute solutions of diblock and triblock copolymers

We investigate the aggregation number and size distributions for inter-molecular clusters of amphiphilic diblock and triblock copolymers in poor solvent at very low concentrations. Diblocks and triblocks with hydrophilic ends are shown to possess narrow distributions corresponding to formation of monodispersed mesoglobules. Diblocks with hydrophobic ends are found to produce inter-cluster multimers due to bridging by the hydrophilic middle blocks, resulting in polydisperse distributions. Implications of these observations for preparation of monodispersed nanoparticles and, potentially, understanding of the quaternary structure of proteins are discussed.Comment: 4 pages, 4 PS figures. Accepted for publication in EP

Universal Role for HLA-C and KIR2Dl Ligand Mismatch in Severe Acute Graft-Versus-Host Disease After Unrelated Donor Hematopoietic Stem Cell Transplantation (U-HSCT) in Japanese and Caucasian Transplant Recipients: An Analysis on Behalf of International Histocompatibility Working Group in Hematopoietic Cell Transplantation

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Melting of tantalum at high pressure determined by angle dispersive x-ray diffraction in a double-sided laser-heated diamond-anvil cell

The high pressure and high temperature phase diagram of Ta has been studied in a laser-heated diamond-anvil cell (DAC) using x-ray diffraction measurements up to 52 GPa and 3800 K. The melting was observed at nine different pressures, being the melting temperature in good agreement with previous laser-heated DAC experiments, but in contradiction with several theoretical calculations and previous piston-cylinder apparatus experiments. A small slope for the melting curve of Ta is estimated (dTm/dP = 24 K/GPa at 1 bar) and a possible explanation for this behaviour is given. Finally, a P-V-T equation of states is obtained, being the temperature dependence of the thermal expansion coefficient and the bulk modulus estimated.Comment: 31 pages, 8 figures, to appear in J.Phys.:Cond.Matte

The Mre11-Rad50-Nbs1 complex mediates activation of TopBP1 by ATM

The activation of ATR-ATRIP in response to double-stranded DNA breaks (DSBs) depends upon ATM in human cells and Xenopus egg extracts. One important aspect of this dependency involves regulation of TopBP1 by ATM. In Xenopus egg extracts, ATM associates with TopBP1 and thereupon phosphorylates it on S1131. This phosphorylation enhances the capacity of TopBP1 to activate the ATR-ATRIP complex. We show that TopBP1 also interacts with the Mre11-Rad50-Nbs1 (MRN) complex in egg extracts in a checkpoint-regulated manner. This interaction involves the Nbs1 subunit of the complex. ATM can no longer interact with TopBP1 in Nbs1-depleted egg extracts, which suggests that the MRN complex helps to bridge ATM and TopBP1 together. The association between TopBP1 and Nbs1 involves the first pair of BRCT repeats in TopBP1. In addition, the two tandem BRCT repeats of Nbs1 are required for this binding. Functional studies with mutated forms of TopBP1 and Nbs1 suggested that the BRCT-dependent association of these proteins is critical for a normal checkpoint response to DSBs. These findings suggest that the MRN complex is a crucial mediator in the process whereby ATM promotes the TopBP1-dependent activation of ATR-ATRIP in response to DSBs