Do mammalian cells synthesize lipoic acid? Identification of a mouse cDNA encoding a lipoic acid synthase located in mitochondria11The nucleotide sequence data of the mLIP1 cDNA for lipoic acid synthase of the mouse were deposited in the DDBJ, EMBL and GenBank nucleotide sequence databases with the accession number AB057731.

AbstractLipoic acid is a coenzyme essential to the activity of enzymes such as pyruvate dehydrogenase, which play important roles in central metabolism. However, neither the enzymes responsible for biosynthesis nor the biosynthetic event of lipoic acid has been reported in mammalian cells. In this study, a mouse mLIP1 cDNA for lipoic acid synthase has been identified. We have shown that the cDNA encodes a lipoic acid synthase by its ability to complement a mutant of Escherichia coli defective in lipoic acid synthase and that mLIP1 is targeted into the mitochondria. These findings suggest that mammalian cells are able to synthesize lipoic acid in mitochondria

Antenna-assembling mechanism test on ETS-7

The Communications Research Laboratory plans to test an antenna-assembling mechanism on the Engineering Test Satellite 7. The test is one of the application missions for the space robotics experiments that will be conducted mainly by the National Space Development Agency of Japan (NASDA). The purpose of the test is to verify the ability of the antenna assembling mechanism to function in space and to experiment on the teleoperation of a space robot to develop antenna-assembling technology. We present the test experiment plans and the outline of the onboard assembling mechanism