Overweight, Diet, Physical Activity, and Hypertension in Low-Income School-Aged Children

The purpose of this cross-sectional, descriptive study was to examine overweight as an independent risk factor for hypertension (HTN) in children, as well as associations among body mass index (BMI), blood pressure, diet, and physical activity. Study participants included 1,284 students in grades five to eight in three school districts in rural northern California. Analysis of variance was used to test for differences in BMI and blood pressure based on diet and physical activity. Pearson’s correlation was used to assess the relationships among blood pressure, BMI, dietary, and physical activity variables. Multiple regression analysis was used to determine independent risk factors for BMI and systolic blood pressure. Forty-four percent of the students were > 85th percentile BMI-for-age. With one blood pressure reading, 28% met the criteria for either pre-hypertension or hypertension using standardized criteria for age, gender, and height. HTN rates were significantly higher for overweight vs. normal weight children (p=.001). Fruit and vegetable intake decreased significantly by grade (р =.001). Regression results showed that soda consumption was an independent risk factor for BMI (p =.001) and that BMI was an independent risk factor for HTN (p=.001). Findings support the need for nutrition education and physical activity promotion programs in these three school districts

Community-Based Exercise & Wellness Program for Chronic Stroke - A Pilot Study

Purpose: The overall goal of this pilot study was to determine the feasibility and effectiveness of an 8 week university-based community exercise and wellness program designed to provide an opportunity for exercise, social interaction, and education on stroke-related health and wellness topics

Patient-Provider Race and Sex Concordance: New Insights into Antibiotic Prescribing for Acute Bronchitis

Objective: To examine whether patient and provider concordance by sex or race predicts antibiotic prescribing for acute bronchitis. Study setting: General Internal Medicine and Family Medicine adult clinics at a large safety-net hospital. Study design: We used a logistic model of prescribing as a function of race and sex concordance. Data extraction: Data were extracted from de-identified patient records for those with an acute bronchitis visit between 2008 and 2010. Principal findings: 71% (95% CI 68%-73%) of visits resulted in an antibiotic prescription. Patients in race-concordant visits were 17% (95% CI 8%-25%) less likely to receive a prescription. Conclusions: Race-concordant outpatient visits were associated with more appropriate antibiotic use. Examination of characteristics such as concordance can improve our understanding of the prescribing process and inform stewardship efforts

Residential proximity to major roadways and prevalent hypertension among postmenopausal women: results from the Women's Health Initiative San Diego Cohort.

BackgroundLiving near major roadways has been linked with increased risk of cardiovascular events and worse prognosis. Residential proximity to major roadways may also be associated with increased risk of hypertension, but few studies have evaluated this hypothesis.Methods and resultsWe examined the cross-sectional association between residential proximity to major roadways and prevalent hypertension among 5401 postmenopausal women enrolled into the San Diego cohort of the Women's Health Initiative. We used modified Poisson regression with robust error variance to estimate the association between prevalence of hypertension and residential distance to nearest major roadway, adjusting for participant demographics, medical history, indicators of individual and neighborhood socioeconomic status, and for local supermarket/grocery and fast food/convenience store density. The adjusted prevalence ratios for hypertension were 1.22 (95% CI: 1.07, 1.39), 1.13 (1.00, 1.27), and 1.05 (0.99, 1.12) for women living ≤100, >100 to 200, and >200 to 1000 versus >1000 m from a major roadway (P for trend=0.006). In a model treating the natural log of distance to major roadway as a continuous variable, a shift in distance from 1000 to 100 m from a major roadway was associated with a 9% (3%, 16%) higher prevalence of hypertension.ConclusionsIn this cohort of postmenopausal women, residential proximity to major roadways was positively associated with the prevalence of hypertension. If causal, these results suggest that living close to major roadways may be an important novel risk factor for hypertension

Levodopa inhibits the development of lens-induced myopia in chicks

Animal models have demonstrated a link between dysregulation of the retinal dopamine system and the development of myopia (short‑sightedness). We have previously demonstrated that topical application of levodopa in chicks can inhibit the development of form‑deprivation myopia (fDM) in a dose‑dependent manner. Here, we examine whether this same protection is observed in lens‑induced myopia (LiM), and whether levodopa’s protection against fDM and LiM occurs through a dopamine D1- or D2-like receptor mechanism. To do this, levodopa was first administered daily as an intravitreal injection or topical eye drop, at one of four ascending doses, to chicks developing LiM. Levodopa’s mechanism of action was then examined by co-administration of levodopa injections with D1-like (SCH-23390) or D2-like (spiperone) dopamine antagonists in chicks developing FDM or LIM. For both experiments, levodopa’s effectiveness was examined by measuring axial length and refraction after 4 days of treatment. Levodopa inhibited the development of LIM in a dose-dependent manner similar to its inhibition of fDM when administered via intravitreal injections or topical eye drops. in both fDM and LiM, levodopa injections remained protective against myopia when co‑administered with ScH‑ 23390, but not spiperone, indicating that levodopa elicits its protection through a dopamine D2-like receptor mechanism in both paradigms.This work was partially funded by ANU Connect Ventures through a Discovery Translation Fund Grant (Project ID: DTF216

Author correction : Levodopa inhibits the development of lens-induced myopia in chicks

Animal models have demonstrated a link between dysregulation of the retinal dopamine system and the development of myopia (short‑sightedness). We have previously demonstrated that topical application of levodopa in chicks can inhibit the development of form‑deprivation myopia (FDM) in a dose‑dependent manner. Here, we examine whether this same protection is observed in lens‑induced myopia (LIM), and whether levodopa’s protection against FDM and LIM occurs through a dopamine D1‑ or D2‑like receptor mechanism. To do this, levodopa was first administered daily as an intravitreal injection or topical eye drop, at one of four ascending doses, to chicks developing LIM. Levodopa’s mechanism of action was then examined by co‑administration of levodopa injections with D1‑like (SCH‑23390) or D2‑like (spiperone) dopamine antagonists in chicks developing FDM or LIM. For both experiments, levodopa’s effectiveness was examined by measuring axial length and refraction after 4 days of treatment. Levodopa inhibited the development of LIM in a dose‑dependent manner similar to its inhibition of FDM when administered via intravitreal injections or topical eye drops. In both FDM and LIM, levodopa injections remained protective against myopia when co‑administered with SCH‑23390, but not spiperone, indicating that levodopa elicits its protection through a dopamine D2‑like receptor mechanism in both paradigms

Higher leptin is associated with hypertension: the Multi-Ethnic Study of Atherosclerosis

Adipokines are secreted from adipose tissue, influence energy homeostasis and may contribute to the association between obesity and hypertension. Among 1897 participants enrolled in the Multi-Ethnic Study of Atherosclerosis, we examined associations between blood pressure and leptin, tumor necrosis factor-α (TNFα), resistin and total adiponectin. The mean age and body mass index (BMI) was 64.7 years and 28.1, respectively, and 50% were female. After adjustment for risk factors, a 1-s.d.-increment higher leptin level was significantly associated with higher systolic (5.0 mm Hg), diastolic (1.9), mean arterial (2.8) and pulse pressures (3.6), as well as a 34% higher odds for being hypertensive (P<0.01 for all). These associations were not materially different when the other adipokines, as well as BMI, waist circumference or waist-to-hip ratio, were additionally added to the model. Notably, the associations between leptin and hypertension were stronger in men, but were not different by race/ethnic group, BMI or smoking status. Adiponectin, resistin and TNFα were not independently associated with blood pressure or hypertension. Higher serum leptin, but not adiponectin, resistin or TNFα, is associated with higher levels of all measures of blood pressure, as well as a higher odds of hypertension, independent of risk factors, anthropometric measures and other selected adipokines

Dissecting a complex chemical stress: chemogenomic profiling of plant hydrolysates.

The efficient production of biofuels from cellulosic feedstocks will require the efficient fermentation of the sugars in hydrolyzed plant material. Unfortunately, plant hydrolysates also contain many compounds that inhibit microbial growth and fermentation. We used DNA-barcoded mutant libraries to identify genes that are important for hydrolysate tolerance in both Zymomonas mobilis (44 genes) and Saccharomyces cerevisiae (99 genes). Overexpression of a Z. mobilis tolerance gene of unknown function (ZMO1875) improved its specific ethanol productivity 2.4-fold in the presence of miscanthus hydrolysate. However, a mixture of 37 hydrolysate-derived inhibitors was not sufficient to explain the fitness profile of plant hydrolysate. To deconstruct the fitness profile of hydrolysate, we profiled the 37 inhibitors against a library of Z. mobilis mutants and we modeled fitness in hydrolysate as a mixture of fitness in its components. By examining outliers in this model, we identified methylglyoxal as a previously unknown component of hydrolysate. Our work provides a general strategy to dissect how microbes respond to a complex chemical stress and should enable further engineering of hydrolysate tolerance

Comparing Self-Reported Sleep Quality and Sleep Disturbance with Physical Activity in Community Dwelling Older Adults

Purpose: To evaluate physical activity and sleep health in community dwelling older adults through use of activity monitors, physical capacity tests, self-reported sleep health, physical health measures, and participation in social roles. We wanted to know how these measures may or may not play a significant role in future physical therapy treatment. Our hypothesis was that self- reported sleep quality and sleep disturbance is correlated to physical activity in community dwelling older adults