6 research outputs found
NFV Orchestration over Disaggregated Metro Optical Networks with End-to-End Multi-Layer Slicing enabling Crowdsourced Live Video Streaming
- Author
- Publication venue
- Publication date
- 01/07/2021
- Field of study
Network infrastructure must support emerging applications, fulfill 5G requirements, and respond to the sudden increase of societal need for remote communications. Remarkably, crowdsourced live video streaming (CLVS) challenges operators' infrastructure with tides of users attending major sport or public events that demand high bandwidth and low latency jointly with computing capabilities at the networks' edge. The Metro-Haul project entered the scene proposing a cost-effective, agile, and disaggregated infrastructure for the metro segment encompassing optical and packet resources jointly with computing capabilities. Recently, a major Metro-Haul outcome took the form of a field trial of network function virtualization (NFV) orchestration over the multi-layer packet and disaggregated optical network testbed that demonstrated a CLVS use case. We showcased the average service creation time below 5 min, which met the key performance indicator as defined by the 5G infrastructure public private partnership. In this paper, we expand our field trial demonstration with a detailed view of the Metro-Haul testbed for the CLVS use case, the employed components, and their performance. The throughput of the service is increased from approximately 9.6 Gbps up to 35 Gbps per virtual local area network with high-performance VNFs based on single-root input/output virtualization technology
Functional Wnt Signaling Is Increased in Idiopathic Pulmonary Fibrosis
- Author
- A Kikuchi
- AF Muro
- AJ Mikels
- AL
- C Li
- CC Lewis
- CJ Scotton
- CY Logan
- DS Kim
- DW Visscher
- EE Morrisey
- EJ Rulifson
- ES White
- Eva-Maria Pfaff
- F Chua
- F Zuo
- FH Brembeck
- FJ Martinez
- Harald H. H. W. Schmidt
- IV Yang
- Izabella Chrobak
- J Bilic
- JE Forde
- K Kitowska
- KM Cadigan
- L Taneyhill
- M Chilosi
- M Konigshoff
- M Perez-Moreno
- M Selman
- M Selman
- M Selman
- Melanie Königshoff
- ML Johnson
- ML Mucenski
- ML Mucenski
- Monika Kramer
- N Walter
- Nisha Balsara
- Oliver Eickelberg
- PW Noble
- R Nusse
- RT Moon
- TE King Jr
- VS Taskar
- W Lu
- W Shu
- W Szeto
- Werner Seeger
- X Fang
- X Guo
- Y Hochberg
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2008
- Field of study
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease, characterized by distorted lung architecture and loss of respiratory function. Alveolar epithelial cell injury and hyperplasia, enhanced extracellular matrix deposition, and (myo)fibroblast activation are features of IPF. Wnt/beta-catenin signaling has been shown to determine epithelial cell fate during development. As aberrant reactivation of developmental signaling pathways has been suggested to contribute to IPF pathogenesis, we hypothesized that Wnt/beta-catenin signaling is activated in epithelial cells in IPF. Thus, we quantified and localized the expression and activity of the Wnt/beta-catenin pathway in IPF. METHODOLOGY/PRINCIPAL FINDINGS: The expression of Wnt1, 3a, 7b, and 10b, the Wnt receptors Fzd1-4, Lrp5-6, as well as the intracellular signal transducers Gsk-3beta, beta-catenin, Tcf1, 3, 4, and Lef1 was analyzed in IPF and transplant donor lungs by quantitative real-time (q)RT-PCR. Wnt1, 7b and 10b, Fzd2 and 3, beta-catenin, and Lef1 expression was significantly increased in IPF. Immunohistochemical analysis localized Wnt1, Wnt3a, beta-catenin, and Gsk-3beta expression largely to alveolar and bronchial epithelium. This was confirmed by qRT-PCR of primary alveolar epithelial type II (ATII) cells, demonstrating a significant increase of Wnt signaling in ATII cells derived from IPF patients. In addition, Western blot analysis of phospho-Gsk-3beta, phospho-Lrp6, and beta-catenin, and qRT-PCR of the Wnt target genes cyclin D1, Mmp 7, or Fibronectin 1 demonstrated increased functional Wnt/beta-catenin signaling in IPF compared with controls. Functional in vitro studies further revealed that Wnt ligands induced lung epithelial cell proliferation and (myo)fibroblast activation and collagen synthesis. CONCLUSIONS/SIGNIFICANCE: Our study demonstrates that the Wnt/beta-catenin pathway is expressed and operative in adult lung epithelium. Increased Wnt/beta-catenin signaling may be involved in epithelial cell injury and hyperplasia, as well as impaired epithelial-mesenchymal cross-talk in IPF. Thus, modification of Wnt signaling may represent a therapeutic option in IPF
RETRACTED ARTICLE: An offline space division multiplexing based elastic optical network model with modulation format adaptation and flexible spectrum and spatial assignment
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Chihuil Sea Catfish Bagre panamensis Viscera as a New Source of Serine Proteases: Semi-purification, Biochemical Characterization and Application for Protein Hydrolysates Production
- Author
- A Bougatef
- A Homaei
- A Sila
- A Zamani
- AC Hernández-Sámano
- AD Neklyudov
- AG Villalba-Villalba
- AG Villalba-Villalba
- AN El-Hadj
- BA Prado
- BF Erlanger
- BW Zhu
- C-H Lu
- CM Le
- D Doucet
- F Aranishi
- F Castillo-Yáñez
- FJ Castillo-Yáñez
- FL GarcĂa-Carreño
- FL GarcĂa-Carreño
- G Carrera
- H Ogino
- I Osuna-Ruiz
- I Younes
- J Adler-Nissen
- J Silva
- JM Moreno-Hernández
- JR Simkhada
- K Jellouli
- LN Murthy
- M Blanco
- M Bradford
- M Castillo-Rivera
- M Chalamaiah
- MA Navarrete-del-Toro
- MD Klein
- ML Flores-Fernández
- N Doukyu
- NJ Adamson
- R Bezerra
- R Saborowski
- RG Valdez-Melchor
- RL Olsen
- RNZRA Rahman
- S Barberis
- S Klomklao
- S Klomklao
- S Raghavan
- T Kudre
- UK Laemmli
- VM Muro-Torres
- X Shen
- Y Hou
- ZY Li
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Hepatitis B virus infection in children
- Author
- Adoga MP
- Akinyinka OO
- Al Awaidy ST
- Allain JP
- Alter H
- Ang LW
- Ashraf H
- Ayano Inui
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- Ayres A
- Beasley RP
- Bialek SR
- Black AP
- Blumberg BS
- Borgia G
- Borgia G
- Bortolotti F
- Bortolotti F
- Boxall EH
- Boxall EH
- Buchanan C
- Bzowej NH
- Bzowej NH
- Cabezas-Sánchez C
- Cai W
- Celen MK
- Chang MH
- Chang TT
- Cheah PL
- Chen CY
- Chongsrisawat V
- Chu M
- Cooksley WG
- Davaalkham D
- Dikici B
- Dominguez A
- Dunkelberg JC
- Edstam JS
- Ekra D
- El Sherbini A
- El-Serag HB
- Escobedo-Melendez G
- Escobedo-Melendez G
- European association for the study of the liver
- Fattovich G
- Fisher EJ
- Fontana RJ
- Françoisa G
- Gish RG
- Gish RG
- Gjorup IE
- Greenup AJ
- Gregorio GV
- Haber BA
- Hadziyannis SJ
- Han GR
- Han L
- Haruki Komatsu
- Heathcote EJ
- Hom X
- Howell J
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- Hsu HY
- Huang X
- Ioannou GN
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- Jafri W
- Jonas MM
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- Kahn J
- Kew MC
- Klingler C
- Komatsu H
- Koyama T
- Kramvis A
- Kumar A
- Lai CL
- Lai CL
- Lai CL
- Lee C
- Li XM
- Liang X
- Liaw Y-F
- Liaw YF
- Liaw YF
- Liaw YF
- Livingston SE
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- Luo Z
- Magnussen A
- Manzat Saplacan RM
- Marcellin P
- Martinson FE
- Marx G
- Matthews SJ
- Menendez C
- Merrill RM
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- Moore SW
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- Muro FJ
- Murray KF
- Nair S
- Nardone A
- Nguyen TH
- Ni YH
- Nordenstedt H
- Ochola E
- Ott JJ
- Paganelli M
- Pan CQ
- Pan CQ
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- Pande C
- Pawlowska M
- Peters MG
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- Peto TJ
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- Poovorawan Y
- Popalis C
- Qaqish RB
- Raimondo G
- Rawal BK
- Reda AA
- Rey-Cuille MA
- Rey-Cuille MA
- Roman S
- Roskams T
- Ruiz-Moreno M
- Saltik-Temizel IN
- Sarkar M
- Satapathy SK
- Seifer M
- Shah U
- Shahmoradi S
- Sherman M
- Silveira TR
- Simani OE
- Singh AE
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- Soeung SC
- Sokal EM
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- Sokal EM
- Spada E
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- Tanaka J
- Tatematsu K
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- Upreti SR
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- Utsumi T
- van Nunen AB
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- Villar LM
- Vo Thi Diem H
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- Wiersma ST
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- Zacharakis G
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- Zou H
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Listing of Protein Spectra
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- S Nees
- S Nees
- S Niculescu
- S Nonomura
- S Odani
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- S Paleus
- S Pollack
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- S Shirai
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- S Takemori
- S Takemori
- S Takohara
- S Tanase
- S Toyama
- S Ueda
- S Ueno
- S Watanabe
- S Werner
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- S Yamamoto
- S Yamamoto
- S Yoshida
- S Yoshida
- S Yoshikawa
- S Yoshikawa
- S. L. Gaff in and S. Watanabe J
- S. L. Gaff in and S. Watanabe J
- S. S. L
- SA Asher
- SA Ghabrial
- SA Ghabrial
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- SH Allen
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- SJ Ferguson
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- SK Patnaik
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- SL Bonting
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- SM Dudkin
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- SOC Tottmar
- SR Parr
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- SS Tate
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- ST Olson
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- SV Paranjpe
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- T
- T Aizono
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- T Beeler
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- T Gomyo
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- T Hirabayashi
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- T Iizuka
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- T Ozawa
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- T Saiki
- T Sakai
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- T Sasaki
- T Sasazuki
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- T Satoh
- T Satyanarayana
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- T Shimizu
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- T Silsand
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- T Stelmaszynska
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- T Sugiyama
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- T Suzuki
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- T Tachiki
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- T Tachiki
- T Takahashi
- T Tanaka
- T Taniguchi
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- T Taniguchi
- T Ueda
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- T Uozumi
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- T Uwajima
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- U Branzoli
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- V Gonzales-Prevatt
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- VT Aikazyan
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- VV Mesyanzhinov
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- W Ardelt
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- WH Bannister
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- WM Awad
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- WV Sweeney
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- WW Fish
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- Y
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- Y Ichikawa
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- Y Imai
- Y Ishida
- Y Itoh
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- Y Morino
- Y Morita
- Y Morita
- Y Motokawa
- Y Muto
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- Y Nakagawa
- Y Nakagawa
- Y Nakamura
- Y Nisimoto
- Y Nisimoto
- Y Ohta
- Y Ohta
- Y Ohta
- Y Ohta
- Y Orii
- Y Orii
- Y Orii
- Y Ota
- Y Peled
- Y Sakagami
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- Y Sanada
- Y Sawada
- Y Schechter
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- Y Seki
- Y Shichida
- Y Shioi
- Y Shioi
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- Y Stefanovsky
- Y Sugimura
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- Y Sugita
- Y Takahara
- Y Tamura
- Y Tanagida
- Y Tani
- Y Tani
- Y Tominaga
- Y Tominatsu
- Y Tominatsu
- Y Watanabe
- Y Yamasai
- Y Yasukochi
- Y Yasukochi
- Y Yoshida
- Y Yoshida
- Y Yoshida
- Y. Miyake T. Abe, and T. Yamano, in International Symposium on Oxidases and Related Redox Systems
- YA Sharonov
- YA Sharonov
- YA Sharonov
- YE Erokhin
- YJ Kang
- YK Turakulov
- YK Turakulov
- YK Yip
- YP Lin
- YP Meyer
- YP Meyer
- YP Meyer
- YP Myer
- YS Choong
- YS Choong
- YV Peive
- YV Peive
- YV Pieve
- YV Shtamm
- YY Vasilev
- YYH Chao
- Z Bradic
- Z Gasyna
- Z Vogel
- Z Zak
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1984
- Field of study