Assessment of Flex-Grid/MCF optical networks with ROADM limited core switching capability

The majority of the research studies on Flex-Grid over multi-core fiber (Flex-Grid/MCF) networks are built on the assumption of fully non-blocking ROADMs (FNB-ROADMs), able to switch any portion of the spectrum from any input core of any input fiber to any output core of any output fiber. Such flexibility comes at an enormous extra hardware cost. In this paper, we explore the trade-off of using ROADMs that impose the so-called core continuity constraint (CCC). Namely, a CCC-ROADM can switch spectrum from a core on an input fiber to a chosen output fiber, but cannot choose the specific output core. For instance, if all fibers have the same number of cores, the i-th core in the input fibers can be just switched to the i-th core in the output fibers. To evaluate the performance vs. cost trade-off of using CCCROADMs, we present two Integer Linear Programming (ILP) formulations for optimally allocating incoming demands in Flex-Grid/MCF networks, where the CCC constraint is imposed or not, respectively. A set of results are extracted applying both schemes in two different backbone networks. Transmission reach estimations are conducted accounting for the fiber’s linear and non-linear effects, as well as the inter-core crosstalk (ICXT) impairment introduced by laboratory MCF prototypes of 7, 12 and 19 cores. Our numerical evaluations show that the performance penalty of CCC is minimal, i.e., below 1% for 7 and 12-core MCF and up to 10% for 19-core MCF, while the cost reduction is large. In addition, results reveal that the ICXT effect can be significant when the number of cores per MCF is high, up to a point that equipping the network with 12-core MCFs can yield superior effective capacity than with 19-core MCFs.Peer ReviewedPostprint (author's final draft

Demonstration of Zero-touch Device and L3-VPN Service Management using the TeraFlow Cloud-native SDN Controller

We demonstrate zero-touch device bootstrapping, monitoring, and L3-VPN service management using the novel TeraFlow OS SDN controller prototype. TeraFlow aims at producing a cloud-native carrier-grade SDN controller offering scalability, extensibility, high-performance, and high-availability features

Functional Wnt Signaling Is Increased in Idiopathic Pulmonary Fibrosis

BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease, characterized by distorted lung architecture and loss of respiratory function. Alveolar epithelial cell injury and hyperplasia, enhanced extracellular matrix deposition, and (myo)fibroblast activation are features of IPF. Wnt/beta-catenin signaling has been shown to determine epithelial cell fate during development. As aberrant reactivation of developmental signaling pathways has been suggested to contribute to IPF pathogenesis, we hypothesized that Wnt/beta-catenin signaling is activated in epithelial cells in IPF. Thus, we quantified and localized the expression and activity of the Wnt/beta-catenin pathway in IPF. METHODOLOGY/PRINCIPAL FINDINGS: The expression of Wnt1, 3a, 7b, and 10b, the Wnt receptors Fzd1-4, Lrp5-6, as well as the intracellular signal transducers Gsk-3beta, beta-catenin, Tcf1, 3, 4, and Lef1 was analyzed in IPF and transplant donor lungs by quantitative real-time (q)RT-PCR. Wnt1, 7b and 10b, Fzd2 and 3, beta-catenin, and Lef1 expression was significantly increased in IPF. Immunohistochemical analysis localized Wnt1, Wnt3a, beta-catenin, and Gsk-3beta expression largely to alveolar and bronchial epithelium. This was confirmed by qRT-PCR of primary alveolar epithelial type II (ATII) cells, demonstrating a significant increase of Wnt signaling in ATII cells derived from IPF patients. In addition, Western blot analysis of phospho-Gsk-3beta, phospho-Lrp6, and beta-catenin, and qRT-PCR of the Wnt target genes cyclin D1, Mmp 7, or Fibronectin 1 demonstrated increased functional Wnt/beta-catenin signaling in IPF compared with controls. Functional in vitro studies further revealed that Wnt ligands induced lung epithelial cell proliferation and (myo)fibroblast activation and collagen synthesis. CONCLUSIONS/SIGNIFICANCE: Our study demonstrates that the Wnt/beta-catenin pathway is expressed and operative in adult lung epithelium. Increased Wnt/beta-catenin signaling may be involved in epithelial cell injury and hyperplasia, as well as impaired epithelial-mesenchymal cross-talk in IPF. Thus, modification of Wnt signaling may represent a therapeutic option in IPF

Comparación de distintas estrategias para la predicción de muerte a corto plazo en el paciente anciano infectado

Objective. The aim of this study was to determine the utility of a post hoc lactate added to SIRS and qSOFA score to predict 30-day mortality in older non-severely dependent patients attended for infection in the Emergency Department (ED). Methods. We performed an analytical, observational, prospective cohort study including patients of 75 years of age or older, without severe functional dependence, attended for an infectious disease in 69 Spanish ED for 2-day three seasonal periods. Demographic, clinical and analytical data were collected. The primary outcome was 30-day mortality after the index event. Results. We included 739 patients with a mean age of 84.9 (SD 6.0) years; 375 (50.7%) were women. Ninety-one (12.3%) died within 30 days. The AUC was 0.637 (IC 95% 0.587-0.688; p= 2 and 0.698 (IC 95% 0.635- 0.761; p= 2. Comparing receiver operating characteristic (ROC) there was a better accuracy of qSOFA vs SIRS (p=0.041). Both scales improve the prognosis accuracy with lactate inclusion. The AUC was 0.705 (IC95% 0.652-0.758; p<0.001) for SIRS plus lactate and 0.755 (IC95% 0.696-0.814; p<0.001) for qSOFA plus lactate, showing a trend to statistical significance for the second strategy (p=0.0727). Charlson index not added prognosis accuracy to SIRS (p=0.2269) or qSOFA (p=0.2573). Conclusions. Lactate added to SIRS and qSOFA score improve the accuracy of SIRS and qSOFA to predict short-term mortality in older non-severely dependent patients attended for infection. There is not effect in adding Charlson index

Assessment of Flex-Grid/MCF optical networks with ROADM limited core switching capability

The majority of the research studies on Flex-Grid over multi-core fiber (Flex-Grid/MCF) networks are built on the assumption of fully non-blocking ROADMs (FNB-ROADMs), able to switch any portion of the spectrum from any input core of any input fiber to any output core of any output fiber. Such flexibility comes at an enormous extra hardware cost. In this paper, we explore the trade-off of using ROADMs that impose the so-called core continuity constraint (CCC). Namely, a CCC-ROADM can switch spectrum from a core on an input fiber to a chosen output fiber, but cannot choose the specific output core. For instance, if all fibers have the same number of cores, the i-th core in the input fibers can be just switched to the i-th core in the output fibers. To evaluate the performance vs. cost trade-off of using CCCROADMs, we present two Integer Linear Programming (ILP) formulations for optimally allocating incoming demands in Flex-Grid/MCF networks, where the CCC constraint is imposed or not, respectively. A set of results are extracted applying both schemes in two different backbone networks. Transmission reach estimations are conducted accounting for the fiber’s linear and non-linear effects, as well as the inter-core crosstalk (ICXT) impairment introduced by laboratory MCF prototypes of 7, 12 and 19 cores. Our numerical evaluations show that the performance penalty of CCC is minimal, i.e., below 1% for 7 and 12-core MCF and up to 10% for 19-core MCF, while the cost reduction is large. In addition, results reveal that the ICXT effect can be significant when the number of cores per MCF is high, up to a point that equipping the network with 12-core MCFs can yield superior effective capacity than with 19-core MCFs.Peer Reviewe

Machine Learning-assisted Planning and Provisioning for SDN/NFV-enabled Metropolitan Networks

After more than ten years of research and development, Software-Defined Networking (SDN) and Network Function Virtualization (NFV) are finally going mainstream. The fifth generation telecommunication standard (5G) will make use of novel technologies to create increasingly intelligent and autonomous networks. The METRO-HAUL project proposes an advanced SDN/NFV metro-area infrastructure based on an optical backbone interconnecting edge-computing nodes, to support 5G and advanced services. In this work, we present the METRO-HAUL planning tool subsystem that aims to optimize network resources from two different perspectives: off-line network design and on-line resource allocation. Off-line network design algorithms are mainly devoted to capacity planning. Once network infrastructure is in production stages and operational, on-line resource allocation takes into account flows generated by end-user-oriented services that have different requirements in terms of bandwidth, delay, Quality Of Service (QoS) and set of VNFs to be traversed. Through the paper, we describe the components inside the planning tool, which compose a framework that enables intelligent optimization algorithms based on Machine Learning (ML) to assist the control plane in taking strategic decisions. The proposed framework aims to guarantee a fair behavior towards past, current and future requests as network resource allocation decisions are assisted with ML approaches. Additionally, interaction schemes are proposed between the open-source Java-based Net2Plan tool, ML libraries and algorithms in Python easing algorithm development and prototyping for rapid interaction with SDN/NFV control and orchestration modules

Gap Analysis on Open Models for Partially-Disaggregated SDN Optical Transport Environments

We report an analysis of completeness and suitability of OpenConfig, OpenROADM and OpenDevice models, for physical-impairment aware network planning, and a proof-of-concept in a partially disaggregated testbed exposing equipment information to Net2Plan through ONOS

Demonstration of Zero-touch Device and L3-VPN Service Management using the TeraFlow Cloud-native SDN Controller

We demonstrate zero-touch device bootstrapping, monitoring, and L3-VPN service management using the novel TeraFlow OS SDN controller prototype. TeraFlow aims at producing a cloud-native carrier-grade SDN controller offering scalability, extensibility, high-performance, and high-availability features