5 research outputs found
Inflammatory bowel disease induces inflammatory and pre-neoplastic changes in the prostate.
- Author
- Publication venue
- eScholarship, University of California
- Publication date
- 25/05/2021
- Field of study
BackgroundInflammatory bowel disease (IBD) has been implicated as a risk factor for prostate cancer, however, the mechanism of how IBD leads to prostate tumorigenesis is not known. Here, we investigated whether chronic intestinal inflammation leads to pro-inflammatory changes associated with tumorigenesis in the prostate.MethodsUsing clinical samples of men with IBD who underwent prostatectomy, we analyzed whether prostate tumors had differences in lymphocyte infiltrate compared to non-IBD controls. In a mouse model of chemically-induced intestinal inflammation, we investigated whether chronic intestinal inflammation could be transferred to the wild-type mouse prostate. In addition, mouse prostates were evaluated for activation of pro-oncogenic signaling and genomic instability.ResultsA higher proportion of men with IBD had T and B lymphocyte infiltration within prostate tumors. Mice with chronic colitis showed significant increases in prostatic CD45 + leukocyte infiltration and elevation of three pro-inflammatory cytokines-TIMP-1, CCL5, and CXCL1 and activation of AKT and NF-kB signaling pathways. Lastly, mice with chronic colitis had greater prostatic oxidative stress/DNA damage, and prostate epithelial cells had undergone cell cycle arrest.ConclusionsThese data suggest chronic intestinal inflammation is associated with an inflammatory-rich, pro-tumorigenic prostatic phenotype which may explain how gut inflammation fosters prostate cancer development in men with IBD
Political Parties in Zambia, Burundi and Togo: Organization, Cohesion and Party-Voter Linkage
- Author
- Add
- Adriano Nuvunga
- Adrienne Lebas
- Afeikhena Jerome
- Afp
- Afp
- Afp
- Afp
- Afp
- Afreepress Info
- Africa Confidential
- Africa Confidential
- Agb�yom� Kodjo
- Alain Mac�
- Alan Ware
- Alex Gomez
- Alex Thomson
- Alexander Stroh
- Andreas Schedler
- Andrew Manley
- Angelo Panebianco
- Anja Osei
- Ann Swidler
- Ann-Kristin Jonasson
- Anna Wolkenhauer
- Arc-En-Ciel
- Arib News
- Aristide R Zolberg
- Atop
- Ayayi Apedo-Amah
- Benjamin N Lawrance
- Bruce Bueno De Mesquita
- Bueno De Mesquita
- Burundi Info
- Burundi News
- C A Berkeley
- Carrie Manning
- Carrie Manning
- Carter Center
- Ceni Burundi
- Ceni Togo
- Cfd
- Charles Piot
- Christine Deslaurier
- Christopher Hopkins
- Citypopulation De
- Com Koaci
- Com Togosite
- Comi M Toulabor
- Comi M Toulabor
- Comi M Toulabor
- Comi M Toulabor
- Cosome
- Cosome
- Cour Constitutionnelle Du Togo
- Cyrus Samii
- Cyrus Samii
- Cyrus Samii
- Dan Paget
- Daniel N Posner
- Danielle Resnick
- Deborah Potts
- Donelson R Forsyth
- Earl R Babbie
- East African
- Edalina Sanches
- Elizabeth A Mcclintock
- Emmanuel Gyimah-Boadi
- Ernesto Laclau
- Ethnologue
- Ethnologue
- Fdd
- Fidh
- Filip Reyntjens
- Frank O&apos
- Fran�oise Boucek
- Garance Mar�chal
- Gero Erdmann
- Gero Erdmann
- Gero Erdmann
- Giacomo Macola
- Gilles Labarthe
- Giovanni M Carbone
- Giovanni Sartori
- G�ran Hyd�n
- G�ran Hyd�n
- H M Drucker
- H M Drucker
- Herbert Kitschelt
- Herbert Kitschelt
- Irin
- Irin
- Iwacu
- Jacques Leclerc
- Jacques Leclerc
- Jaimie Bleck
- Jaimie Bleck
- James Coleman
- Janvier D Nkurunziza
- Jean De Menthon
- Jean-Pierre Olivier De Sardan
- Jennifer C Seely
- Jennifer C Seely
- Jennifer C Seely
- Jeremy Gould
- Jeuneafrique
- Jeuneafrique
- Jeuneafrique
- Jeuneafrique
- Jeuneafrique
- Jeuneafrique
- Jeuneafrique Com
- Johan De Smedt
- John Gerring
- John Gerring
- John H Aldrich
- John R Heilbrunn
- Jotham C Momba
- Jotham Momba
- Julien Morency-Laflamme
- Justin Pearce
- Kassahun Berhanu
- Katharine Murison
- Kathryn Nwajiaku
- Kay Lawson
- Kay Lawson
- Kay Lawson
- Ketil F Hansen
- Koaci
- Koaci
- Kossigan A Adjah
- Labit� Agbodjan-Prince
- Ladislav Holy
- Lars Sv�sand
- Le Combat Du Peuple
- Lib�ral
- Linda Van Buren
- Lise Rakner
- Lise Rakner
- Lthd
- Luc Christiaensen
- Lusaka Times
- Lusaka Times
- Lusaka Times
- Lusaka Times
- Maarten J Voors
- Marc Pilon
- Marc Pilon
- Marco Stampini
- Marina Ottaway
- Mathurin C Houngnikpo
- Matthias Basedau
- Matthijs Bogaards
- Maurice Duverger
- Michael Bratton
- Michael Burawoy
- Michael Burawoy
- Michelle Osborn
- Miles Larmer
- Moe Ue Au Burundi
- Moe Ue Au Togo
- Moe Ue Au Togo
- Muvi Tv
- Nakpane Labante
- Ndi/Fodep
- Nic Cheeseman
- Nicolas Van De Walle
- Nicolas Van De Walle
- Oag
- Org Burundiimage
- Org Wikipedia
- Panapress
- Patrick Chabal
- Patrick Chabal
- Patrick Chabal
- Patriotic Front
- Paul Nugent
- Paul Nugent
- Peter Heller
- Peter J Burnell
- Petr Skaln�k
- Phaniso Kalua
- Philippe Bocquier
- Radim Tobolka
- Radim Tobolka
- Radim Tobolka
- Rene Lemarchand
- Ren� Lemarchand
- Rfi
- Rfi
- Rfi
- Rfi
- Rfi
- Rfi
- Richard Gunther
- Richard L Sklar
- Robert Michels
- Robert R Barr
- Ruth Morgenthau
- Sabine C Carey
- Samuel Decalo
- Stephen Atalebe
- Steven Levitsky
- Sulaiman Y Kura
- Svein-Erik Helle
- Teke Ngomba
- Theodore Trefon
- Thierry Uwamahoro
- Thomas Carothers
- Thomas Hodgkin
- Thomas Poguntke
- Togo Cvjr Du
- Togo Infos
- Togoactualite
- Tyson Roberts
- Uct
- Unir
- Unir
- Upnd
- Vicky Randall
- Vicky Randall
- Vicky Randall
- Vincent Foucher
- Vivien Foster
- Vlastimil Fiala
- Von Trotha
- Wes Sharrock
- William Neuman
- Willy Nindorera
- Willy Nindorera
- Xinhua
- Yanhong Zhang
- Zambian Intelligence
- Zibani Maundeni
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2014
- Field of study
Coronal Heating as Determined by the Solar Flare Frequency Distribution Obtained by Aggregating Case Studies
- Author
- Aaron James Holland
- Abdullah Jumana T.
- Abrams Jonathan M.
- Abrashoff Riley
- Acevedo Andres B.
- Acha Iker
- Acosta Daniela M. Meza
- Adam Megan M.
- Adams Dante Q.
- Adams Elena R
- Adams Kalvyn N
- Akbar Zainab A.
- Akruwala Ushmi H.
- Al-Ghazwi Adel
- AlAbbas Batool H.
- Alahmed Mohammed S.
- AlAwadhi Areej A.
- Albakr Mohammed A.
- Albalushi Yusef J.
- Albaum Jonathan
- Aldhamen Ahmed
- Ales Nolan
- Alesmail Mohammad
- Alhabeeb Abdulelah
- Alhamli Dania
- AlHarbi Yazeed A.
- Alhuseini Isehaq
- Alkaabi Suhail
- Alkhezzi Tameem
- Alkubaisi Mohamed
- Allanqawi Nasser
- Allsbrook Martin
- Almohsen Yousef A.
- Almquist Justin Thomas
- Alnaji Teeb
- Alnasrallah Yousef A
- Alonzi Nicholas
- Alosaimi Meshal
- Alqabani Emeen
- Alrubaie Mohammad
- Alsinan Reema A.
- Altenbern Ava L.
- Altokhais Abdullah
- Alyami Saleh A.
- Ameijenda Federico
- Amer Hamzi
- Amos Meggan
- Anderson Hunter J.
- Andrew Carter
- Andringa Jesse C
- Angwin Abigail
- Aradhya Arvind J.
- Aramians Andrew
- Arango Camila Villamil
- Archibald Jack. W.
- Arias-Robles Brian A.
- Aryan Maryam
- Ash Kevin
- Astalos Justin
- Atchley-Rivers N. S.
- Augenstein Dakota N.
- Austin Bryce W.
- Avula Abhinav
- Aycock Matthew C.
- Baflah Abdulrahman A.
- Balaji Sahana
- Balajonda Brian
- Balcer Leo M
- Baldwin James O.
- Banda David J
- Bard Titus
- Barmore Abby
- Barnes Grant M.
- Barnhart Logan D. W.
- Barone Kevin M.
- Bartman Jessica L.
- Bassel Claire
- Bastias Catalina S
- Bat-Ulzii Batchimeg
- Batra Jasleen
- Battist Lexi
- Bay Joshua
- Beach Simone
- Beard Sara
- Beato Quinn I
- Beattie Ryan
- Beatty Thomas
- Beauprez Jacob N.
- Beck Lily
- Beck M. G.
- Becker Simone E.
- Behr Braden
- Behrer Timothy A.
- Beijer Joshua
- Belei Brennan J.
- Belknap Annelene L.
- Bell Aislyn
- Bence Caden
- Benke Evan
- Berhanu Naomi
- Berriman-Rozen Zachary D.
- Bertuccio Chrisanna
- Berv Owen A.
- Biediger Blaine B.
- Biehle Samuel J
- Billig Brennen
- Billingsley Jacob
- Billman Jayce A.
- Biron Connor J.
- Bisacca Gabrielle E.
- Blake Cassidy A.
- Blandon Guillermo
- Blevins Olivia
- Blouin Ethan
- Bodzianowski Michal
- Boeyink Taylor A.
- Bondar Matthew
- Bone Lauren
- Bonilla Alberto Espinosa de los Monteros
- Borelli William T
- Borgerding Luke R.
- Bowen Troy
- Boyer Aidan
- Boyer Christine
- Boyle Aidan P.
- Boyne Tom
- Branch Donovan
- Brecl Ariana E.
- Brennan David J.
- Brimhall Alexander J
- Brockman Jennifer L.
- Brookins Sarah
- Brown Cameron L.
- Brown Gabriel T.
- Brown Ryan
- Brownlow Jordi
- Brumage-Heller Grant
- Brumley Preston J.
- Bryan Samuel
- Brzostowicz A.
- Buhamad Maryam
- Bullard-Connor Gigi
- Bunsow J. R. Ramirez
- Burns Annemarie C.
- Burritt John J.
- Burton Nicholas David
- Burton Taylor
- Busch Celeste
- Butler Dylan R.
- Buxton B. W.
- Cabbage Carter C.
- Cage Breonna
- Cahn Jackson R.
- Cai Yijian
- Campbell Andrew J
- Canales Braden P.
- Cancio Alejandro R.
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- Carillion Emma L.
- Carpender Michael Andrew
- Carpenter Emily
- Chadda Shivank
- Chambers Paige
- Chanders Jasey
- Chandler Olivia M.
- Chang Ethan C.
- Chaparro David
- Chapman Logan T.
- Chapman Mitchell G.
- Chavali S.
- Chavez Luis
- Cheang Nathan M.
- Chen Judy
- Chen Kevin
- Chen Lily
- Chen Sam
- Chhetri Jenisha
- Chiles Bradyn
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- Christiansen Katherine E
- Cisne Nicholas A.
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- Clark David B.
- Clarke Evelyn
- Clarkson Peter C
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- Coe Ryan W.
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- Colleran Zachary
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- Collins Sarah
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- Colter Aurora
- Cone Rebecca A.
- Conroy Thomas C.
- Conti Reese
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- Cool Destiny J.
- Cooper Nicholas M.
- Corbitt Jessica S
- Courtney Jonas
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- Craig Wilmsen B.
- Creany Joshua B.
- Crews Anastasia
- Crocker K. A.
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- Crow Christian J.
- Cruse Zoe
- Cruz Avril
- Curnow Tyler L.
- Current Hayden
- Curry Riley T.
- Cutler Libby
- Cyr Aidan St.
- Dabberdt Frederick M.
- Daboub Johnston
- Damgaard Olivia
- Das Swagatam
- Davis Emma A. B.
- de La Beaujardiere Tristan
- DeBarros Elyse
- Deel Sean
- Del Foco Leonardo
- Delasantos Megan E.
- Deng Tianyue
- Derwin Zachary
- Desai Om
- Dewey Kai
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- Dixon Alyssa M.
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- Do Helen C.
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- Doane Connor
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- Doermer Timothy
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- Domke Emerson N.
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- Dresdner Danielle C.
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- Elbashir Sara I.
- Engelhardt Rasce
- Engelstad Jacob
- England Colin
- Enrich Andrew
- Erickson Abbey
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- Erikson James W.
- Evans Nathan
- Ewing Calvin A
- Eyeson Elizabeth A.
- Faber Ian
- Fails Avery M.
- Fauntleroy John T
- Fell Kevin
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- Fenwick Logan D.
- Feoktistov Nikita
- Fife Ryann
- Figueirinhas John Alfred D.
- Fisch Jean-Paul
- Fischer Emmalee
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- Fitton Aidan F.
- Fix Alexander
- Flackett Lydia
- Flores Fernando
- Floyd Aidan
- Folarin Adeduni
- Forbes Aidan E.
- Fortino Elise
- Fougere Benjamin L.
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- Fox Margaret
- French James M.
- French Katherine V.
- Frick Florian G.
- Fuchs Calvin R.
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- Galarraga Gabriela
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- Gapin Keala C.
- Garscadden A. J.
- Gasser Rachel
- Gayou Lily
- Gearhart Emily E.
- Geerdts T. R.
- Geisman Jane
- Geneser Julianne R.
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- Gerhardstein Phillip
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- Gopalakrishnan Sean
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- Juels Parker
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- Kelly James
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- Khan Usman
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- Kimlicko Aspen
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- Kirkpatrick Hunter B.
- Kissner Natalie
- Kite Emily R.
- Kleinhaus Olivia R.
- Knott Philip Whiting
- Koch Will
- Koenig Greta
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- Krajnak Zack
- Kresek Zoe M.
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- Kritzberg Jake E.
- Krueger Davis J.
- Kubiak Bartlomiej
- Kuehl Kirsten
- Kuester Chrisanne
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- Kumar Aman Priyadarshi
- Kuybus Connor
- Kwiatkowski Daniel
- Lacjak Kevin
- LaFemina Quintin Y.
- Lahmers Kyle
- Lam Antonia
- Landrey Kalin
- Lantz Maxwell B.
- Larter Zachary
- Lau Benjamin P.
- Lauzon Megan
- Lawlor Rian
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- Lengerich Dylan
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- Li David Y.
- Li Isaac
- Liao Ryan Z.
- Linders Bridget
- Linger Morgan I
- Linnane Katherine B.
- Lippincott Sam
- Lister Barrett
- Litton Shelby D
- Liu Haixin
- Liu Nianzi
- Liu Steven Y.
- Logan Timothy W.
- Londres Nathan
- Lonergan Mia C.
- Lookhoff Emily
- Loomis N. E.
- Lopez Christian
- Lordi Noah
- Loring Justin
- Lucca Jeffrey
- Lukianow Dax
- Luo Zheng
- MacDonald William
- Madonna Claire A.
- Madsen Kasey O.
- Maksimuk Tiffany E.
- Mallory Macguire
- Malone Ryan A.
- Maly Blake
- Manzanares Xander R.
- Maravi Aimee S.
- Marcus Serafima M.
- Marikar Nasreen
- Marquez Josie A.
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- Martin Logan S.
- Martinez Alexa M.
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- Martinez Jose R.
- Martyr Cara
- Mason James Paul
- Masri Mirna
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- Mathieson Randi M.
- Mathur Kabir P.
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- Mayer Victoria A.
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- McCammon Glen S.
- McConvey Rowan
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- McCoy Andrew
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- McGarvey Meaghan V.
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- Peck Courtney
- Pedersen Alexander J.
- Pellatz Nick
- Pelster Lily M.
- Peou Munisettha E.
- Perez Freddy
- Perez J. S.
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- Petersen Audrey J.
- Peterson B.
- Petric Romeo S. L.
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- Phalen Ethan J.
- Pham Alexander V.
- Phan Denise M.
- Pherigo Callie C
- Phillips Justin
- Phillips Lance
- Phommatha Krista
- Pietras Alex
- Pine Tawanchai P.
- Pitsuean-Meier Sedique
- Pitten John
- Pixley Andrew M.
- Plantz Will
- Plummer William C.
- Plutt Kaitlyn E.
- Plzak Audrey E.
- Pohle Kyle
- Polikoff Hyden
- Pollard Matthew
- Polly Madelyn
- Porter Trevor J.
- Price David
- Price Nicholas K.
- Prinster Gale H.
- Propper Henry Austin
- Quarderer Josh
- Quinn Megan S.
- Quinonez Oliver
- Quispe Devon
- Ragsdale Cameron
- Rahn Anna L.
- Rakhmonova M.
- Ralapanawe Anoush K
- Ramachandra Nidhi
- Ramirez Ariana C.
- Ramirez Nathaniel
- Ramirez Sacha
- Randolph Parker
- Ranjan Anurag
- Rankin Frederick C
- Rapaport Sarah Grace
- Ratajczyk Nicholas O
- Ray Mia G. V.
- Reagan Brian D.
- Recchia John C.
- Reddy Brooklyn J.
- Reed Charlie
- Reed Joseph
- Reeves Justin
- Reh Eileen N.
- Reyna Andrea B.
- Reynolds Alexander
- Reynolds Hope
- Rippel Matthew
- Rivas Guillermo A.
- Rives Anna Linnea
- Robert Amanda M.
- Robertson Samuel M.
- Rodgers Maeve
- Rojec Stewart
- Romero Andres C.
- Rosasco Ryan
- Rossman Beth
- Rotter Michael
- Rounsefell Tyndall
- Rouse Charlotte
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- Roy Marc G.
- Roy Zoe A.
- Ruger Ryan
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- Rule Ian C.
- Rumley Madigan
- Runyon Brenton M.
- Ruprecht Collin
- Russell Bowman
- Russell Sloan
- Ryder Diana
- Saeb David
- Salazar J.
- Salazar Violeta
- Salcido-Alcontar JR Antonio
- Saldi Maxwell
- Salgado Jose A.
- Salindeho Adam D.
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- Sanchez Ethan S.
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- Sarfaraz Darian
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- Savage Carl
- Schaller Marcus T.
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- Schofer Matthew J
- Schubert Stephanie H.
- Schultze Courtney
- Schumacher Grace K
- Seglem Kasper
- Serio Lauren
- Seux Octave
- Shahba Hannan
- Shannahan Callie D.
- Sharma Shajesh
- Shaver Nathan
- Shaw Timothy
- Shelby Arlee K.
- Shelby Emma
- Shelchuk Grace
- Sheldrake Tucker
- Sherry Daniel P.
- Shi Kyle Z.
- Shields Amanda M.
- Shin Kyungeun
- Shitara Nanako
- Shockley Michael C.
- Shoha Dominick
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- Singh Maya A.
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- Sipowicz Leo
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- Smith Corey
- Smith Elena K.
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- Solorio William J.
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- Spangler Ava A
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- Stamos Emily
- Starbuck Peter
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- Starling Travis
- Staudenmier Caitlyn
- Steckhahn Daniel
- Steinbarth Sheen L.
- Steinsberger Christopher H.
- Stepaniak Tyler
- Steward Ellie N.
- Stewart T. C.
- Stewart Trey
- Stratmeyer Cooper N.
- Stratton Grant L.
- Stribling Jordin L.
- Sulaiman S. A
- Sullivan Brandon J
- Sundell M. E.
- Sur Sohan N.
- Suri Rohan
- Swartz Jason R.
- Sweeney Joshua D.
- Syed Konner
- Szabo Emi
- Szeremeta Philip
- Ta Michael-Tan D.
- Tanguma Nolan C.
- Taulman Kyle
- Taylor Eleanor
- Taylor Liam C.
- Taylor Nicole
- Tayman K. E.
- Tellez Yesica
- Terrile Richard
- Tesdahl Corey D
- Thielmann Quinn N.
- Thoman Gerig
- Thomas Daniel
- Thomas Jeffrey J.
- Thompson William N.
- Thornally Noah R.
- Tobin Darien P.
- Ton Kelly
- Toon Nathaniel J.
- Toups Malena C.
- Tran Bryn
- Tran Kevin
- Trank-Greene Maedee
- Trautwein Emily D.
- Traxler Robert B.
- Tressler Judah
- Trofino Tyson R.
- Troisi Thomas
- Trunko Benjamin L.
- Truong Joshua K.
- Tucker Julia
- Umbricht Thomas D
- Uphoff C. H.
- Upthegrove Zachary T.
- Vadayar Shreenija
- Valencia Whitney
- Vallery Mia M.
- Van Anne Gabreece
- VanEtten Eleanor
- Vann John D.
- Varela Ilian
- Vassilyev Alexandr
- Vaver Nicholas J.
- Velamala Anjali A.
- Vendetti Evan
- Venegas Nancy Ortiz
- Vepa Aditya V.
- Vess Marcus T.
- Veta Jenna S.
- Victory Andrew
- Vinson Jessica
- Visal Aseem
- Vogel Connor Maklain
- von Peccoz Charles B. Beck
- Von Reich Ferin J.
- Wagoner Michaela
- Wallace Logan
- Wallace Steven P.
- Waller Caroline
- Wang Chaoran
- Wang Hongda
- Wang Jiawei
- Warble Keenan
- Ward-Chene N. R. D.
- Watson James Adam
- Weber Robert J.
- Wegner Aidan B.
- Weigand Anthony A
- Weiner Amanda M.
- Werth Alexandra
- West Ayana
- West Colin G.
- Wexler Ethan Benjamin
- Wheeler Nicola H.
- White Jamison R.
- White Oliver S.
- White Zachary
- Whittall Lloyd C.
- Wickenden Evan
- Wilcove Isaac
- Wilkinson Blake C.
- Willard John S.
- Williams Abigail K.
- Williams Sajan
- Wilson Connor B.
- Wilson Evan M.
- Wilson John
- Wilson Orion K.
- Wilson Timothy R.
- Witkoff Briahn
- Wolfe Aubrey M.
- Wolle Jackson R.
- Wood Travis M.
- Woodard Aiden L.
- Woodraska Donald L.
- Wootten Katelynn
- Wu Mengyu
- Xiao Catherine
- Yang Jianing
- Yang Zhanchao
- Yegovtsev Nikolay
- Young Isabel
- Young Trenton J.
- Youngblood Allison A.
- Zenner Thomas
- Zhang Jiaqi
- zhang Jinhua
- Zhao Noah Y.
- Zhao Tiannie
- Zhao Tianwei
- Zhou Chongrui
- Ziebold Josh J
- Ziegler Lucas J.
- Zimmermann Ingrid H
- Zygmunt James C.
- Publication venue
- 'American Astronomical Society'
- Publication date
- 09/05/2023
- Field of study
Flare frequency distributions represent a key approach to addressing one of
the largest problems in solar and stellar physics: determining the mechanism
that counter-intuitively heats coronae to temperatures that are orders of
magnitude hotter than the corresponding photospheres. It is widely accepted
that the magnetic field is responsible for the heating, but there are two
competing mechanisms that could explain it: nanoflares or Alfv\'en waves. To
date, neither can be directly observed. Nanoflares are, by definition,
extremely small, but their aggregate energy release could represent a
substantial heating mechanism, presuming they are sufficiently abundant. One
way to test this presumption is via the flare frequency distribution, which
describes how often flares of various energies occur. If the slope of the power
law fitting the flare frequency distribution is above a critical threshold,
α=2 as established in prior literature, then there should be a
sufficient abundance of nanoflares to explain coronal heating. We performed
>600 case studies of solar flares, made possible by an unprecedented number
of data analysts via three semesters of an undergraduate physics laboratory
course. This allowed us to include two crucial, but nontrivial, analysis
methods: pre-flare baseline subtraction and computation of the flare energy,
which requires determining flare start and stop times. We aggregated the
results of these analyses into a statistical study to determine that α=1.63±0.03. This is below the critical threshold, suggesting that Alfv\'en
waves are an important driver of coronal heating.Comment: 1,002 authors, 14 pages, 4 figures, 3 tables, published by The
Astrophysical Journal on 2023-05-09, volume 948, page 7
Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries
- Author
- A Yacoub Mina
- A. Adam Mohammed
- A. Nassar Mahmoud
- A.Nemer Ayoob
- Aahlin Eirik Kjus
- Ab Rahim Mohd Fadliyazid
- Abad Gurumeta Alfredo
- Abad-Motos Ane
- Abang Jamari Dyg Zahratul Hamrak
- Abantanga Francis
- Abarca Sol
- Abazid Eias
- Abbas Abbas
- Abbas Khalid
- Abbas Mohammad Monir
- Abbasy Jibran
- Abbosh Ali
- Abd Karim Muhammad Fairuz Shah
- Abd Wahab Haidar Hadri
- Abd Barook
- Abdalei Abdulwahab
- Abdalla Ahmed Elkamel Ahmed
- Abdallah Aya
- AbdAllah Mostafa Salim Mohamed
- Abdel Malik Abu Baker
- Abdelhady Mousa Heba
- Abdelhady Samar
- Abdelhakim Ahmed
- Abdelkader Muhammad
- Abdelkawy Shaza
- Abdelkhalek Mohamed
- Abdellatif Esraa
- Abdelmaksoud Tawakel Noura
- Abdelmohsen Naglaa
- Abdelmotaleb Ibrahem
- Abdelrazek Aly
- Abdelsalam Israa
- Abdelshakour Mahmoud
- Abdelwahed Ahmed Mohamed
- Abdou Abdulrahman Osama
- Abdou Alrawy
- Abdou Hossam
- Abdul Aziz Mohamed Rezal
- Abdul Aziz Nora
- Abdulgawad Almogy Mariam
- Abdulla Mazin A.
- Abdullah Muhammad Tariq
- Abdullahi Lawal
- Abdullayev Seymur
- Abed Saeed
- Abelló David
- Abiola Olajide
- Abo mahadi Asmaa'
- Abo-khammash Areej
- Abou Chaar Mohamad K.
- Abou El.soud Moustafa Ramadan
- Abouelsoad Nervana
- Abraham Joyner
- Abreu da Silva Alberto
- Abu Ahammala Ayman B.
- Abu Al Amrain Mahmoud
- Abu Al-saleem Hasan
- Abu Alamrain Abdulwhhab
- Abu Alqumboz Amjad
- Abu Ataya Ahmed
- Abu hallalah Muad fathi khalleefah
- Abu Jamie Najlaa
- Abu Jayyab Israa
- Abu shua'ib Rana
- Abu Zainah Baraa
- Abu-Nimeh Samar
- Abu-Rous Mohammed R.
- Abu-srour Abrar
- Abuelhatal Hasan
- Abuelqomboz Ayham
- Abuhilal Baseel
- Abuhlaiga Ma'aly
- Abujamra Saleh
- Abukhalaf Sadi A.
- Abusalem Lana
- AbuSirrees Mahmoud
- Acevedo Veronica
- Acharya Rajgopal
- Achkasov Sergey
- Acosta Eric
- Adamo Karin
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- Adams Jamie
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- Adawi Samer
- Adebanjo Ademola
- Adel Marina
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- Adeyeye Ademola
- Adidharma Peter
- Adisa Adewale O
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- Afifi Eman
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- Aguilera Maria Lorena
- Aguilera-Arevalo Maria-Lorena
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- Ahmed Ahmedgaber
- Ahmed Hazem Abdelkarem
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- Ahmed Zahra
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- Aithie Joanna M S
- Ajani Costanza
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- Nahas Louei
- Nair Amrita
- Nair Gopikrishnan
- Nair Nita
- Nakazwe Mildred
- Napolitano Lena
- Naqi Syed Asghar
- Nasir Abdulrasheed
- Nassar Ahmed
- Nasser Hamamah Ayat Allah
- Nassif Mohammed
- Navarro Martínez Sergio
- Navarro-Sánchez Antonio
- Nazir Anam
- Nazzal Ahmed
- Nazzal Ranin
- Ndayishimiye Isaac
- Ndegbu Chinedu
- Ndong Abdourahmane
- Neelamraju Lakshmi Harish
- Negoi Ionut
- Negoita Valentina Madalina
- Nehra Deepak
- Nepogodiev Dmitri
- Nessa Ashrafun
- Nevado García Cristina
- Neves Christian
- Neves Jessica
- Newall Nicola
- Newman Elliot
- Nezerwa Yves
- Ng We Yong Yuki Julius
- Ng Elaine Hui Been
- Ng James Chean Khun
- Ng Li-Yen
- Ng Michael
- Ng Nathan
- Ngai Carlin
- Ngotho Omar
- Nicholson Gary
- Nico Albano Miguel
- Nigard Linda
- Nigo Samuel Lemery
- Nikberg Maziar
- Nikoloudis Nikolaos
- Nina Helidon
- Nino- Torres Laura
- Niquen Jimenez Maria Milagros
- Nita Gabriela Elisa
- Nogueira Sixto Manuel
- Nogueira Oriana
- Nomura Andrea
- Noor Fazlin
- Norcic Gregor
- Norman Lisa
- Nour Ibrahim
- Novoa Armando
- Nozal Beatriz
- Nsengimana Vizir J.P.
- Nsengiyumva Carlos
- Ntaoulas Sotirios
- Ntirenganya Faustin
- Nubani Yanal
- Nugrahadi Nadia Rahmadiani
- Nunoo-Mensah Joseph
- Nutautiene Vitalija
- Nwachukwu Callistus
- Nwokocha Samuel
- Nwolu Favour
- Nyangoh Timoh Krystel
- O'Connor Donal B
- O'Neill Maeve
- O'Shea Margaret
- Obaid Mohammed
- Obery Gareth
- Occhionorelli Savino
- Oganezov Giorgi
- Ogundoyin Olakayode
- Ojewola Rufus Wale
- Okalany Noella
- Olajide Thomas Olagboyega
- Olaogun Julius
- Olasehinde Olalekan
- Olazo Espejo Dennet Arturo
- Oliveira Ana Carolina
- Oliveira Joana
- Oliveira Mariline
- Oliveira Simone
- Olivier James
- Oliwa Agata
- Olona Carles
- Olori Samson
- Olugbemi Mojolaoluwa
- Omar F. Aljadidi Wesal
- Omar Cinderella
- Omar Mohamed
- Omar Samah
- Omar Shrouk
- Omar Waleed
- Omarain Ahmad
- Omer Omer Abdelbagi
- Ongaro Deborah
- Onglao Mark Augustine
- Onuoha Clement
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- Orhalmi Julius
- Orlowski Michal
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- Osama Abeer
- Osei-Poku Dorcas
- Osman Fahima
- Osorio Miguel
- Otero de Pablos Jaime
- Otero-Diez Jorge L.
- Othman Gehad
- Otieno James
- Ottesen Taylor
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- Oung Thida
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- Owusu Abem Emmanuel
- Owusu senior Atta
- Owusu Frank
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- Pace Ugo
- Pacheco André
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- Padmore Greg
- Pagano Gianluca
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- Paniagua García Señorans Marta
- Panieri Eugenio
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- Papageorgiou Dimitrios
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- Paramzin Fedor
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- Parker Andrea
- Parker Robert
- Parseliunas Audrius
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- Parvaiz Muhammad Asad
- Parvez Elena
- Pascale Giovanni
- Pascoe Rebecca
- Paspala Anna
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- Paškevicius Sigitas
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- Pearson Robert
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- Pedro Vera
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- Pedziwiatr Michal
- Pegba-Otemolu Ibifunke
- Peixoto Rita
- Pektas Ahmet Murat
- Pellegrino Luca
- Pellino Gianluca
- Peltrini Roberto
- Pengermä Pasi
- Pepe Vincenzo
- Pera Miguel
- Perdomo Perez Mauro Andres
- Perduca Pietro
- Pereira Jorge
- Pereira José Carlos
- Pereira Mário
- Perepelytsia Kateryna
- Perera Omattage Mahasha
- Perez Rivera Carlos J-
- Perivoliotis Konstantinos
- Peros Georgios
- Perrone Fabrizio
- Perrone Kenneth
- Pesenti Giovanni
- Peterer Lorenz
- Peters Adrian
- Petkov Plamen
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- Pham Lily
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- Picciariello Arcangelo
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- Pipe Michelle
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- Prakash Prajwala
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- Prasad Uday
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- Prieto-Nieto Maria Isabel
- Prodromidou Anastasia
- Prosper Ngwang
- Pulcina Guenda
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- Qahoush Rami
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- Rabee Abdelrahman
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- Razafimanjato Narindra Njarasoa Mihaja
- Realis Luc Alberto
- Recinos Gustavo
- Reda Loaloa Mohamed
- Refaat Ahmed
- Refky Basel
- Rega Daniela
- Reia Marta
- Reinisch Katharina Beate
- Rems Miran
- Rencuzogullari Ahmet
- Reyes Afonso Eduardo
- Riad Aya
- Ribeiro da Silva Bruno
- Ribeiro Hugo
- Ribeiro João
- Richards Simon
- Richards Sophie
- Ridgway Paul
- Ridley William
- Ripollés-Melchor Javier
- Rivera Lara Verónica
- Rivero Déniz Joaquín
- Rizzo Giovanna
- Robertson Harry
- Rocha Melo Miguel
- Rocha Ana
- Rodicio Miravalles Jose Luis
- Rodrigues Ferreira Joana
- Rodriguez Fraga Pastora
- Rodriguez Gonzalez Agustin
- Rodriguez-Aguirre Montserrat
- Rodriguez-Lopez Mario
- Rodríguez Angeles Yamile
- Rodríguez Cantera Gabriela
- Rodríguez Fernández Laura
- Rojo López Jose Alberto
- Roldón Golet Marta
- Romano Joana
- Romano Manuela
- Romanova Ekaterina
- Romanukha Kateryna
- Romero-Garza Hector Hugo
- Rompou Vaia-Aliki
- Rooney Siobhan
- Rosado Daniela
- Rose Anna
- Rosko Damir
- Roslani April Camilla
- Rosser Kenrick
- Roszkowski Rafal
- Rotolo Giulia
- Rottier Simone
- Roum Radwa
- Ruano Poblador Alejandro
- Rubinkiewicz Mateusz
- Rubio-Perez Ines
- Rueda Nataly
- Rufo Crespo Erika
- Rugendyke Anya
- Ruiz Soriano María
- Ruiz-Tovar Jaime
- Rupani Shamil
- Russo Alfio Alessandro
- Rutherford Duncan
- Rutkovskii Valeryan
- Rutkovskii Vasilii
- Rybakov Evgeny
- Rye Dupinderjit
- Rzepa Anna
- S Vinay
- Sa'deh Mohammad
- Saad Ahmad
- Saad Mahmoud
- Saadeh Rana
- Sabry Ahmed
- Sacco Michele
- Sacdalan Marie Dione
- Saddouh Enas
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- Sagnotta Andrea
- Sahbaz Nuri Alper
- Sahin Can
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- Saif Areeba
- Saifutdinova Karina
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- Sajith Gautham
- Sajjan Vinay
- Saladyte Justina
- Salama Ebram
- Salameh Mohammad Hasan
- Salameh Roqaya
- Salami Omotayo
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- Salazar Anna Leah
- Sale Danjuma
- Saleem Abdulaziz
- Saleem Omair
- Saleh Bakeer
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- Samison Luc Hervé
- Sammarco Giuseppe
- Sammour Tarik
- Sammut Kim
- Sampaio da Nóvoa Gomes Miguel Inês Isabel
- Sampaio Soares António
- Sampietro Gianluca Matteo
- Samra Tahani
- Samy Fatma
- Sanchez Bartra Nestor Alberto
- Sanchez Andres
- Sanchez-Santos Raquel
- Santandrea Letizia
- Santarrufina Martinez Sandra
- Santos Bezerra Tainá
- Santos Inês
- Santos Vanessa
- Sapallanay Ojeda Olenka
- Sapienza Paolo
- Saqqa Bader
- Sara Samer
- Sarfraz Muzna
- Sarici Inanc Samil
- Sarrami Mahsa
- Sarwar Muhammad
- Sasia Diego
- Savenkov Dmytro
- Savli Evrim
- Sawiee Adnan
- Sayed Mohamed Marwa
- Sayed Ahmed
- Sayed Taqwa
- Sayyed Raza
- Scala Dario
- Scaramuzzo Rosa
- Schizas Dimitrios
- Schrire Timothy
- Sciaudone Guido
- Sciuto Pablo
- Seak Jonathan Chen Ken
- Sebastián Tomás Juan Carlos
- Seeger Nico
- Segovia Lohse Helmut Alfredo
- Sehrish Rahmat
- Seire Indrek
- Sel EDA KÜBRA
- Seldon Yeshey
- Sellars Kate
- Selvaggi Francesco
- Selvaggi Lucio
- Semeda Nourhan
- Semiz Anil
- Sena Giuseppe
- Senanayake Kithsiri Janakantha
- Sequeira Sangita
- Sequeiros Diego
- Sera Ahmed shible
- Sera Marwa
- Settipalli Krishna Pranathi
- Sevim Sule
- Seyoji Mohammed
- Sgrò Alessandro
- Shaeeb Zuhour
- Shah Max
- Shah Reena
- Shaheen Ahmad
- Shaheen Nureddin
- Shahien Fatma
- Shahzad Noman
- Shaker Nancy
- Shakhmatov Dmitry
- Shalaby Hind I.
- Shalaby Mostafa
- Sharif Randa
- Sharma Parivrudh
- Shaw Catherine A
- Shaw Mike
- Shawqi Muhammad
- Shazly Omar
- Shebani Abdulhalim
- Shehab-Eldeen Noura
- Shehada Mohammed
- Shehada Tarneem
- Shenoy Aneesh
- Sheriff Mohammed
- Sheshe Abdurrahman Abba
- Shihada Karam
- Shivashankar Chikkanayakanahalli Santhosh
- Shiwani Haaris
- Shkokani Sundus
- Sholadoye Tunde T.
- Sholi Tasnim
- Shong Sheng Tan
- Shrikhande Shailesh
- Shu Yip Sebastian
- Shushval Mikhail
- Siaw Jia yng
- Sibilla Maria Grazia
- Sierra Sebastian
- Sihotang Retta Catherina
- Silva de Sousa Fabiana
- Silva Anaisa
- Silva Marta
- Silva Sofia
- Silva-Vaz Pedro
- Simcikas Dainius
- Simel Ian
- Simic Andrea
- Simuchimba Elliot
- Simões Joana
- Sinead Mackay
- Sinha Aanjaneya
- Sinibaldi Giovanni
- Siow Jin Phuah
- Siryi Stanislav
- Siso Raber Christian
- Skoczylas Tomasz
- Skroubis George
- Slavchev Mihail
- Slepavicius Algirdas
- Slim Skander
- Sluiter Nina
- Smart Neil
- Smith Scott
- Smith Stephen
- Smolskas Edgaras
- Sobhy Mohamed
- Sokolov Manol
- Solano-Genesta Manuel
- Solar-Garcia Lorena
- Soliman Mostafa
- Soliman Nourhan Akram
- Solinas Luigi
- Sollazzo Viviana
- Sorrentino Luca
- Soula Enas
- Soulabaille Lucie
- Sousa Diogo
- Sowemimo Olamiposi
- Speake Doug
- Spence Richard
- Spiezio Giovanni
- Spinelli Antonino
- Spoletini Domenico
- Sridhar Shruthi
- Srivastava Prakhar
- Sroor Fathy
- Srour Abedelrahman
- St-Amour Pénélope
- Stakelum Aine
- Stakyte Migle
- Stanek Maciej
- Stanley Mwenda Aruyaru
- Starr Robert
- Steenkamp Christina Johanna
- Stellingwerf Merel Elisabeth
- Stevenson Annie
- Stewart Caitlin
- Stewart Peter
- Steynfaardt Leandi
- Stift Anton
- Stock Simon
- Stoica Bogdan
- Stoots Simone
- Stoyanov Vladislav
- Suarez Antonio
- Subocius Andrejus
- Subramaniam Suren
- Sudeikyte Monika
- Sulaiman Syariz Ezuan
- Suleihat Ahmad
- Suleiman Ibrahim
- Sulpice Laurent
- Sultan Abdullah
- Sultan Ahmed
- Summerour Virginia
- Sund Malin
- Suradi Haya H.
- Suresh Gayathri
- Suresh Rishi
- Sushkov Oleg
- Suárez Sánchez Aida
- Svagzdys Saulius
- Syed Aamir Ali
- Syed Bilal
- Syllaios Athanasios
- Sylvester Kimutai
- Syminas Vilius
- Szabadhegyi Gabor
- Szabó Réka
- Szyszka Bartosz
- Sánchez Suárez Ramses
- Sánchez-García Jorge
- Sánchez-Guillén Luis
- Søreide Kjetil
- Tababa Osama
- Tabiri Stephen
- Tagliabue Fulvio
- Taglietti Lucio
- Taha Ehab
- Taha Esraa
- Tahboub Haya
- Tahir Abd al-Rahman
- Taiwo Agboola
- Taiwo Ogechukwu
- Takala Sini
- Talal El-Abur Issa
- Talavera Cherry
- Tamelis Algimantas
- Tamini Nicolò
- Tamosiunas Albinas
- Tampaki Ekaterini Christina
- Tampo Mayou Martin
- Tan Ern Hwei Jeremy
- Tan Daniel
- Tan Gerald Jack Soon
- Tan Hao Han
- Tan Ryan Renxin
- Tan Tanna
- Tang Yita
- Tanis Pieter
- Tankel James
- Tapia Marin Walezka
- Tapkire Ritesh
- Taranu Viorel
- Tarek Ahmed
- Taré Filipa
- Tashkandi Hanaa
- Tashkandi Wail
- Tatar Ozan Can
- Tavlas Panagiotis
- Tawalbeh Ra'fat
- Tawalbeh Tamara
- Tayar Serkan
- Teasdale Ella
- Teh Jen
- Tejeda Garrido Jorge Carlos Guillermo
- Tennakoon Athula
- Tepe Mustafa Deniz
- Teppo Sandra
- Ter Alvin Zubin
- Teras Jyri
- Tereshchenko Maksym
- Tew Yong Yong
- Thakkar Purvi
- Thalgaspitiya Sujeewa Priyantha Bandara
- Tharanath Kavya
- Tharwat Hoda
- Theodoropoulos Charalampos
- Theodorou Dimitrios
- Theodosopoulos Theodosios
- Theofanis George
- Thomas Hannah
- Thomas Jimmy Scott
- Thomas-Jones Iolo
- Thompson Amari
- Thompson Joanna
- Thorell Anders
- Tin Moe Moe
- Tinton Nicolas
- Tiong Ing Ching
- Titan Ashley
- Tlhomelang Omphile
- Todorov George
- Tojal André
- Tol Isabel
- Tomas Kadir
- Tomazic Ales
- Tomé Miguel
- Tondo Matteo
- Tonini Valeria
- Torre Ana
- Torrent Jansà Laia
- Toscano Pacheco Andrea
- Toussaint Arnaud
- Townson Adam
- Trabulsi Nora
- Trenba Sarah
- Triantafyllou Tania
- Tribedi Thomas
- Troche Pesqueira Noemí
- Troche José Manuel
- Troilo Francesca
- Trompetto Mario
- Tropeano Francesca Paola
- Trostchansky Ivan
- Truan Nuria
- Trugeda-Carrera Maria Soledad
- Trujillo Díaz Jeancarlos
- Trullenque Juan Ramon
- Truncíková Vendula
- Truong Anthony
- Truszkiewicz Katarzyna
- Tryliskyy Yegor
- Tsandiraki Justin
- Tsimpoukelis Antonios
- Tucker Sally
- Tulley Joshua
- Turati Luca
- Turri Giulia
- Turunen Antti
- Turunen Arto
- Tutino Roberta
- Tuynman Jurriaan
- Tyselskiy Volodimir
- Tzovaras George
- Tüfek Ozan yavuz
- Türkyilmaz Serdar
- Ubartas Nerijus
- Ugoletti Lara
- Ugolini Giampaolo
- Ulusahin Mehmet
- Umenze Franklin
- Umoke Ifeanyi
- Underwood Charlotte
- Unger Lukas Walter
- Urbieta Aitor
- Urbonas Tomas
- Uribe Valencia Andres
- Usai Antonella
- Usta Arif
- Utrilla Fornals Alejandra
- Uwakunda Carine
- Uy Gemma Leonora
- Uysal Muhammed
- V Sushmita
- Valente da Costa Ana
- van Berge Henegouwen Mark I.
- van Dalen Anne Sophie
- Van Der Merwe Lisa Hannah
- van Geloven Aaw
- Van hentenryck Marie
- van Praag Elise Maria
- van Schilt Kaz
- Van Straten Stephanie
- van Wyngaard Tirsa
- Vanagas Tomas
- Vanella Serafino
- Vanoye Elva Gabriela
- Vardanyan Armen
- Varghese Shriya
- Varol Ecenur
- Vaska Ashish I
- Vaughan-Shaw Peter G
- Vaysse Charlotte
- Vazquez Fernandez Andrea
- Veale Kelly
- Vega Victor
- Veiga Diogo
- Velez Cristina
- Venskutonis Donatas
- Venturelli Paolina
- Verdaguer Tremolosa Mireia
- Vergara María
- Vergara-Fernandez Omar
- Vervoort Dominique
- Vescio Giuseppina
- Viacheslav Nezamai
- Vicario Bravo Marina
- Vidal Meza Maitza Rosario
- Vieira Barros Aldo
- Vieira Caroço Teresa
- Vieira Ana
- Vieira Bárbara
- Vigorita Vincenzo
- Vijaykumar D.K.
- Vijeyan Harinthiran
- Viljoen Francois
- Villalobos Santiago
- Vincenti Leonardo
- Violi Paola
- Virbickaite Egle
- Vlek Stijn
- Volovetskyi Anton
- Wafaa Mariam
- Wafqui fatima Zahraa
- Wagner Gabriela
- Wakkaf Habib
- Waledziak Maciej
- Wall Ellen
- Walsh Una
- Walter Catherine
- Wan Khazim Wan Khamizar
- Wan Muhmad Wan Farahiyah
- Wandschneider Wiebke
- Wanniang Cliff
- Waqar Shahzad Hussain
- Warden Claire
- Warren Craig Russell
- Warren Oliver
- Warwick Andrea
- Warwicker Sean
- Wason Deepender
- Waterman Ade
- Watts Daniel
- Weiser Thomas G
- Welch Matthew
- Wellington Jack
- Wells Anna
- Wells Cameron
- West Malcolm
- Westerduin Emma
- Weyl Ariane
- Whisker Lisa
- Whitaker John
- White Rebecca
- Wiberg Rebecca
- Widmer Lukas Werner
- Wierdak Mateusz
- Wijekoon Arachchilage Nimeshi
- Willemin Melissa
- Williams Christopher Yee Khang
- Wills Vanessa
- Wilson Karim
- Wilson Michael
- Wimmer Kerstin
- Wineberg Devorah
- Winiarski Marek
- Winoto Hadi
- Winter Beatty Jasmine
- Winter Des
- Wisal Maham
- Wisselink Daan
- Wogensen Fredrik
- Wondoh Paul M.
- Wong Florence
- Wong Hsu Ven
- Wong Jane J
- Wong Jeremy
- Wong Lai Fen
- Wong Michael Pak-Kai
- Wong Sui-Weng
- Wong Tsz Lun Ernest
- Wood Lauren
- Woon-Shoo-Tong Xiao-Ming Sarah
- Wren Sherry
- Wuraola Funmilola
- Xanthopoulou Georgia
- Yabut Kenneth
- Yacoub Aseel
- Yaghi Nadine
- Yaghi Yasmine
- Yahia Mohamed Ali Mohamed
- Yakushkina Al'ona
- Yalçinkaya Ali
- Yang P Zichu
- Yanikoglu Erkan
- Yanni Fady
- Yates Charlotte
- Ye Geoffrey
- Yeen Chin Leow
- Yemez Kürsat
- Yenidünya Nilüfer
- Yenli Edwin
- Yeo Jeremy
- Yeoh Andrea
- Yesilsancak Merve
- Yildirim Reyyan
- Yildiz Alp
- Yilmaz Duygu
- Yip Ching Wan
- Ylatoma Díaz Edgar Alcides
- Yong Shun Qi
- Yoong Andrel
- Yorke Joseph
- Yotsov Tsanko
- You Lucia
- Younes Eman
- Younes Maha
- Yousry Basant
- Yozgatli Tahir Koray
- Yu Kristin
- Yue Sum Yu Pansy
- Yunes Asmaa
- Yusuf Baasil
- Yüksel Osman
- Zabiyaka Mikhail
- Zachariah Sanoop Koshy
- Zafar Syed Nabeel
- Zaffaroni Gloria
- Zahra Baryab
- Zahran Diaaaldin
- Zakaria Andee Dzulkarnaen
- Zakaria Mai
- Zakaria Omar
- Zakaria Zaidi
- Zambrana Campos Vanesa
- Zammit Matthew
- Zanini Nicola
- Zara Vlu Jean
- Zara Vlu Jean
- Zarti Heba
- Zarzycki Piotr
- Zattoni Davide
- Zavala Gabriela
- Zawahrah Hassan
- Zeiton Asaid
- Zeko Amanda
- Zeng Zhi
- Zeromskas Paulius
- Zhang Geoffrey
- Zhivkov Evgeni
- Zid Esraa
- Zidan Ahmed Mohy
- Zielasek Christian
- Zilinskas Justas
- Zimmermann Bernd
- Ziprin Paul
- Zizzo Maurizio
- Zografos George
- Zoikas Athanasios
- Zorrilla Matilla Laura Patricia
- Zoulamoglou Menelaos
- Zreeg Dafer
- Zub-Pokrowiecka Anna
- Zubiaurre Vanessa
- Zuhdy Mohammed
- Zuikyte Diana
- Zuloaga Fernandez del Valle Carlos Jose
- Zulu Stanley
- Ângelo Miguel
- Älgå Andreas
- Çolak Elif
- Ümarik Toomas
- Šatkauskas Mindaugas
- Škimelyte Monika
- Šlenfuktas Vygintas
- Šuman Oliver
- Žatecký Jan
- Žumbakys Žygimantas
- Župan Domagoj
- Publication venue
- 'Elsevier BV'
- Publication date
- 30/01/2021
- Field of study
© 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 licenseBackground: 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality. Methods: This was a multicentre, international prospective cohort study of consecutive adult patients undergoing surgery for primary breast, colorectal, or gastric cancer requiring a skin incision done under general or neuraxial anaesthesia. The primary outcome was death or major complication within 30 days of surgery. Multilevel logistic regression determined relationships within three-level nested models of patients within hospitals and countries. Hospital-level infrastructure effects were explored with three-way mediation analyses. This study was registered with ClinicalTrials.gov, NCT03471494. Findings: Between April 1, 2018, and Jan 31, 2019, we enrolled 15 958 patients from 428 hospitals in 82 countries (high income 9106 patients, 31 countries; upper-middle income 2721 patients, 23 countries; or lower-middle income 4131 patients, 28 countries). Patients in LMICs presented with more advanced disease compared with patients in high-income countries. 30-day mortality was higher for gastric cancer in low-income or lower-middle-income countries (adjusted odds ratio 3·72, 95% CI 1·70–8·16) and for colorectal cancer in low-income or lower-middle-income countries (4·59, 2·39–8·80) and upper-middle-income countries (2·06, 1·11–3·83). No difference in 30-day mortality was seen in breast cancer. The proportion of patients who died after a major complication was greatest in low-income or lower-middle-income countries (6·15, 3·26–11·59) and upper-middle-income countries (3·89, 2·08–7·29). Postoperative death after complications was partly explained by patient factors (60%) and partly by hospital or country (40%). The absence of consistently available postoperative care facilities was associated with seven to 10 more deaths per 100 major complications in LMICs. Cancer stage alone explained little of the early variation in mortality or postoperative complications. Interpretation: Higher levels of mortality after cancer surgery in LMICs was not fully explained by later presentation of disease. The capacity to rescue patients from surgical complications is a tangible opportunity for meaningful intervention. Early death after cancer surgery might be reduced by policies focusing on strengthening perioperative care systems to detect and intervene in common complications. Funding: National Institute for Health Research Global Health Research Unit
Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study
- Author
- A Yacoub Mina
- A. Adam Mohammed
- A. Nassar Mahmoud
- A.Nemer Ayoob
- Aahlin Eirik Kjus
- Ab Rahim Mohd Fadliyazid
- Abad Gurumeta Alfredo
- Abad-Motos Ane
- Abang Jamari Dyg Zahratul Hamrak
- Abantanga Francis
- Abarca Sol
- Abazid Eias
- Abbas Abbas
- Abbas Khalid
- Abbas Mohammad Monir
- Abbasy Jibran
- Abbosh Ali
- Abd Karim Muhammad Fairuz Shah
- Abd Wahab Haidar Hadri
- Abd Barook
- Abdalei Abdulwahab
- Abdalla Ahmed Elkamel Ahmed
- Abdallah Aya
- AbdAllah Mostafa Salim Mohamed
- Abdel Malik Abu Baker
- Abdelhady Mousa Heba
- Abdelhady Samar
- Abdelhakim Ahmed
- Abdelkader Muhammad
- Abdelkawy Shaza
- Abdelkhalek Mohamed
- Abdellatif Esraa
- Abdelmaksoud Tawakel Noura
- Abdelmohsen Naglaa
- Abdelmotaleb Ibrahem
- Abdelrazek Aly
- Abdelsalam Israa
- Abdelshakour Mahmoud
- Abdelwahed Ahmed Mohamed
- Abdou Abdulrahman Osama
- Abdou Alrawy
- Abdou Hossam
- Abdul Aziz Mohamed Rezal
- Abdul Aziz Nora
- Abdulgawad Almogy Mariam
- Abdulla Mazin A.
- Abdullah Muhammad Tariq
- Abdullahi Lawal
- Abdullayev Seymur
- Abed Saeed
- Abelló David
- Abiola Olajide
- Abo mahadi Asmaa'
- Abo-khammash Areej
- Abou Chaar Mohamad K.
- Abou El.soud Moustafa Ramadan
- Abouelsoad Nervana
- Abraham Joyner
- Abreu da Silva Alberto
- Abu Ahammala Ayman B.
- Abu Al Amrain Mahmoud
- Abu Al-saleem Hasan
- Abu Alamrain Abdulwhhab
- Abu Alqumboz Amjad
- Abu Ataya Ahmed
- Abu hallalah Muad fathi khalleefah
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- McManus Brendan
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- Wondoh Paul M.
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- Yanikoğlu Erkan
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- Ye Geoffrey
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- Yenli Edwin
- Yeo Jeremy
- Yeoh Andrea
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- Yeşilsancak Merve
- Yildirim Reyyan
- Yildiz Alp
- Yilmaz Duygu
- Yip Ching Wan
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- Yong Shun Qi
- Yoong Andrel
- Yorke Joseph
- Yotsov Tsanko
- You Lucia
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- Yüksel Osman
- Zabiyaka Mikhail
- Zachariah Sanoop Koshy
- Zafar Syed Nabeel
- Zaffaroni Gloria
- Zahra Baryab
- Zahran Diaaaldin
- Zakaria Andee Dzulkarnaen
- Zakaria Mai
- Zakaria Omar
- Zakaria Zaidi
- Zambrana Campos Vanesa
- Zammit Matthew
- Zanini Nicola
- Zara Vlu Jean
- Zarti Heba
- Zarzycki Piotr
- Zattoni Davide
- Zavala Gabriela
- Zawahrah Hassan
- Zeiton Asaid
- Zeko Amanda
- Zeng Zhi
- Zeromskas Paulius
- Zhang Geoffrey
- Zhivkov Evgeni
- Zid Esraa
- Zidan Ahmed Mohy
- Zielasek Christian
- Zilinskas Justas
- Zimmermann Bernd
- Ziprin Paul
- Zizzo Maurizio
- Zografos George
- Zoikas Athanasios
- Zorrilla Matilla Laura Patricia
- Zoulamoglou Menelaos
- Zreeg Dafer
- Zub-Pokrowiecka Anna
- Zubiaurre Vanessa
- Zuhdy Mohammed
- Zuikyte Diana
- Zuloaga Fernandez del Valle Carlos Jose
- Zulu Stanley
- Ângelo Miguel
- Älgå Andreas
- Çolak Elif
- Ümarik Toomas
- Čepuliené Daiva
- Şahin Can
- Šatkauskas Mindaugas
- Škimelytè Monika
- Šlenfuktas Vygintas
- Šuman Oliver
- Žatecký Jan
- Žumbakys Žygimantas
- Župan Domagoj
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/07/2022
- Field of study
© 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licenseBackground: Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide. Methods: A multimethods analysis was performed as part of the GlobalSurg 3 study—a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital. Findings: Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3·85 [95% CI 2·58–5·75]; p<0·0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63·0% vs 82·7%; OR 0·35 [0·23–0·53]; p<0·0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer. Interpretation: Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised. Funding: National Institute for Health and Care Research