Materials chemistry under high pressures - Some recent aspects

Among the thermodynamic parameters governing the preparation of novel materials, temperature (T) and pressure (p) play an important role. In Materials Chemistry, the synthesis of materials needs energy in order to enhance the diffusion of atoms to the equilibrium positions required by the specific structure and to induce the formation of chemical bonds..

The Submillimeter Array

The Submillimeter Array (SMA), a collaborative project of the Smithsonian Astrophysical Observatory (SAO) and the Academia Sinica Institute of Astronomy and Astrophysics (ASIAA), has begun operation on Mauna Kea in Hawaii. A total of eight 6-m telescopes comprise the array, which will cover the frequency range of 180-900 GHz. All eight telescopes have been deployed and are operational. First scientific results utilizing the three receiver bands at 230, 345, and 690 GHz have been obtained and are presented in the accompanying papers.Comment: 10 pages, 4 figure

Reliability of Smartphone Inclinometry to Measure Upper Cervical Range of Motion.

Context: Assessment of upper cervical range of motion (UCROM) and mobility is commonly performed in the clinical setting for patients suffering from headache, neck pain and vestibular dysfunction. Reliable and reproducible measurement of this motion is often difficult or too expensive to perform in the clinical setting. Smartphone applications, utilizing the device\u27s internal gyroscope, offer an easy and inexpensive means of measuring UCROM, but their reliability has not been reported in the literature. Objective: Assess the reliability of an inclinometer application, installed on two different devices (iPhone6 (IP), Andriod (AN)), to measure UCROM in a healthy population. Design: Two examiners assessed passive UCROM. Each examiner was assigned to a specific smartphone and a repeated measures design consisting of three trials for each examiner-phone was performed. The order of testing was randomized and the examiners were blinded to UCROM measures. Setting: Laboratory Participants: 38 subjects (19F, 19M; 23.8±1.2 yrs) without pain or injury to the neck and spine for at least 3 months. Intervention: Each examiner passively flexed the head fully and then rotated the head fully in one direction then in another. Peak rotation measures were recorded from each smartphone. Three trials were performed for each phone with a 2-minute break between examiners/phones. Main Outcome Measures: Intraclass Correlation Coefficient (ICC) using a two way mixed, absolute agreement model were obtained (1) between each examiner-phone and (2) within each examiner-phone for the measurements in each rotation direction. Results: Inter-phone/examiner reliability comparing average peak and total UCROM for each device were excellent (0.87, 0.81). Intra-phone/examiner reliability, determined across three trials, was also excellent (AN Right Rot. = 0.91, AN Left Rot. 0.96, IP Right Rot. = 0.98, IP Left = 0.95 Rot.). Conclusion: UCROM can be reliably measured using a smartphone inclinometer application

Proper Motion of Water Masers Associated with IRAS 21391+5802: Bipolar Outflow and an AU-Scale Dusty Circumstellar Shell

We present VLBA observations of water maser emission associated with the star-forming region IRAS 21391+5802, which is embedded in a bright rimmed cometary globule in IC1396. The angular resolution of the maps is about 0.8 mas, corresponding to a spatial resolution of about 0.6 AU, at an estimated distance of 750 pc. Proper motions are derived for 10 maser features identified consistently over three epochs, which were separated by intervals of about one month. The masers appear in four groups, which are aligned linearly on the sky, roughly along a northeast-southwest direction, with a total separation of about 520 AU (about 0.7 arcseconds). The 3-D velocities of the masers have a maximum value of about 42 km/s (about 9 AU/yr). The average error on the derived proper motions is about 4 km/s. The overall pattern of proper motions is indicative of a bipolar outflow. Proper motions of the masers in a central cluster, with a projected extent of about 20 AU, show systematic deviations from a radial outflow. However, we find no evidence of Keplerian rotation, as has been claimed elsewhere. A nearly circular loop of masers lies near the middle of the cluster. The radius of this loop is 1 AU and the line-of-sight velocities of the masers in the loop are within 2 km/s of the systemic velocity of the region. These masers presumably exist at the radial distance where significant dust condensation occurs in the outflow emanating from the star.Comment: 15 pages, 4 figures. Accepted for publication in the Astrophysical Journal. Version 2.12.00: Astrometric coordinates of maser revise

Water Defluoridation: Nanofiltration vs Membrane Distillation

Nowadays, fluoride contamination of drinking water is a major problem for various countries, because high concentrations of fluoride pose a risk of dental and skeletal fluorosis. Over past years, membrane nanofiltration (NF) has been proposed as convenient defluoridation technology. However, NF cannot be applied to water systems with high fluoride concentration, and the disposal of the membrane concentrate remains an issue. In this work, we compared a commercial polyester NF membrane and a polypropylene hollow-fiber membrane distillation (MD) module for their ability to remove fluoride ions from water in the presence of hardness ions and organic fouling agents. The NF membrane can offer more than 10 times higher water productivity than MD, under realistic gradients of temperature and pressure, respectively. Despite that, after reaching a concentration factor of about 3, fouling and scaling caused the flux to drop to about 80% with respect to its initial value. Moreover, F- retention decreased from 90% to below 80%, thus providing a permeate of scarce quality. MD was operated in the direct-contact mode on a polypropylene hollow-fiber membrane, which was charged with a hot feed flow (average T = 58 °C) on one side and a cooled (20 °C) permeate flow of distilled water on the other side. The concentration of fluoride ions in the permeate was always below the detection limit of our electrode (0.2 ppm), regardless of the fluoride concentration in the feed. Moreover, the MD module showed higher resistance to fouling and scaling than NF, and CaF2 crystals were recovered from the MD concentrate after cooling. These results suggest that the synergic combination of the two techniques might be beneficial for the purification of fluoride-contaminated water systems: MD can be used to further concentrate the NF retentate, thus producing high-purity water and recovering CaF2 crystals.Fil: Moran Ayala, Lucia Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: Paquet, Marie. University of Aalborg; DinamarcaFil: Janowska, Katarzyna. University of Aalborg; DinamarcaFil: Jamard, Paul. University of Aalborg; DinamarcaFil: Quist Jensen, Cejna A.. University of Aalborg; DinamarcaFil: Bosio, Gabriela Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: Martire, Daniel Osvaldo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: Fabbri, Debora. Università di Torino; ItaliaFil: Boffa, Vittorio. University of Aalborg; Dinamarc

Mediation effects that emulate a target randomised trial:Simulation-based evaluation of ill-defined interventions on multiple mediators

Many epidemiological questions concern potential interventions to alter the pathways presumed to mediate an association. For example, we consider a study that investigates the benefit of interventions in young adulthood for ameliorating the poorer mid-life psychosocial outcomes of adolescent self-harmers relative to their healthy peers. Two methodological challenges arise. First, mediation methods have hitherto mostly focused on the elusive task of discovering pathways, rather than on the evaluation of mediator interventions. Second, the complexity of such questions is invariably such that there are no well-defined mediator interventions (i.e. actual treatments, programs, etc.) for which data exist on the relevant populations, outcomes and time-spans of interest. Instead, researchers must rely on exposure (non-intervention) data, that is, on mediator measures such as depression symptoms for which the actual interventions that one might implement to alter them are not well defined. We propose a novel framework that addresses these challenges by defining mediation effects that map to a target trial of hypothetical interventions targeting multiple mediators for which we simulate the effects. Specifically, we specify a target trial addressing three policy-relevant questions, regarding the impacts of hypothetical interventions that would shift the mediators' distributions (separately under various interdependence assumptions, jointly or sequentially) to user-specified distributions that can be emulated with the observed data. We then define novel interventional effects that map to this trial, simulating shifts by setting mediators to random draws from those distributions. We show that estimation using a g-computation method is possible under an expanded set of causal assumptions relative to inference with well-defined interventions, which reflects the lower level of evidence that is expected with ill-defined interventions. Application to the self-harm example in the Victorian Adolescent Health Cohort Study illustrates the value of our proposal for informing the design and evaluation of actual interventions in the future