In vitro characterization of solute transport in the spinal canal

PID2020-115961RB-C31PID2020-115961RB-C32PID2020- 115961RA-C33MCIN/AEI/10.13039/501100011033Junta de Andalucia and European Funds, Project No. P18-FR-4619Spanish Ministry of UniversitiesFellowship FPU18/05694U.S. National Science Foundation through Grant No. 185395

An in vitro experimental investigation of oscillatory flow in the cerebral aqueduct

This in vitro study aims at clarifying the relation between the oscillatory flow of cerebrospinal fluid (CSF) in the cerebral aqueduct, a narrow conduit connecting the third and fourth ventricles, and the corresponding interventricular pressure difference. Dimensional analysis is used in designing an anatomically correct scaled model of the aqueduct flow, with physical similarity maintained by adjusting the flow frequency and the properties of the working fluid. The time-varying pressure difference across the aqueduct corresponding to a given oscillatory flow rate is measured in parametric ranges covering the range of flow conditions commonly encountered in healthy subjects. Parametric dependences are delineated for the time-averaged pressure fluctuations and for the phase lag between the transaqueductal pressure difference and the flow rate, both having clinical relevance. The results are validated through comparisons with predictions obtained with a previously derived computational model. The parametric quantification in this study enables the derivation of a simple formula for the relation between the transaqueductal pressure and the stroke volume. This relationship can be useful in the quantification of transmantle pressure differences based on non-invasive magnetic-resonance-velocimetry measurements of aqueduct flow for investigation of CSF-related disorders.National Institutes of Health/ National Institute of Neurological Diseases and Stroke through contract # 1R01NS120343-0

En marcha con las TIC : recopilación de un año de noticias TICs

Se recopilan aportaciones de docentes extremeños que han llevado a cabo iniciativas relacionadas con las nuevas tecnologías, el acceso libre a la información y el software libre. Se describen los proyectos llevados a cabo por la administración educativa extremeña para promocionar el uso de las tecnologías de la información y la comunicación, entre otras: la plataforma educativa Rayuela, el proyecto de formación a distancia Avanza, el portal del docente Profex, etc..ExtremaduraConsejería de Educación. Dirección General de Política Educativa; Calle Delgado Valencia, 6; 06800 Mérida (Badajoz); +34924006714; +34924006716; [email protected]