Kaposi's sarcoma in a patient with erythroblastopenia and thymoma: Reactivation after topical corticosteroids

We report a 69-year-old female with erythroblastopenia and thymoma who developed lesions of Kaposi's sarcoma (KS) after thymectomy, 2 months after the initiation of therapy with methylprednisolone. Control of mucocutaneous KS lesions was obtained with radiotherapy, interferon alfa-2b and withdrawal of systemic immunosuppressive therapy. Erosive oral lichen planus appeared later, and after therapy with topical corticosteroids a new lesion of KS developed that regressed after withdrawal of topical corticosteroids. The detection of HHV-8 only in lesional skin supports the hypothesis that this virus can trigger the development of KS lesions

Probing IMF using nanodust measurements from inside Saturn's magnetosphere

We present a new concept of monitoring the interplanetary magnetic field (IMF) by using in situ measurements of nanodust stream particles in Saturn's magnetosphere. We show that the nanodust detection pattern obtained inside the magnetosphere resembles those observed in interplanetary space and is associated with the solar wind compression regions. Our dust dynamics model reproduces the observed nanodust dynamical properties as well as the detection pattern, suggesting that the ejected stream particles can reenter Saturn's magnetosphere at certain occasions due to the dynamical influence from the time‐varying IMF. This method provides information on the IMF direction and a rough estimation on the solar wind compression arrival time at Saturn. Such information can be useful for studies related to the solar wind‐magnetosphere interactions, especially when the solar wind parameters are not directly available. Key Points A new method to probe IMF with nanodust measurements inside the magnetosphere Under changing IMF, ejected nanoparticles can re‐enter Saturn‐s magnetosphere IMF direction and solar wind compression arrival time can be derivedPeer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/99078/1/grl50604.pd

Paleoenvironmental and diagenetic evolution of the Aptian Pre-Salt succession in Namibe Basin (Onshore Angola)

The Aptian Pre-Salt sedimentary succession cropping out in Cangulo palaeovalley onshore Namibe Basin (Angola) was studied by a combination of field and analytical techniques to constrain the sedimentary and diagenetic evolution of the uppermost sag sequence of the South Atlantic passive margin. Field observations allows definition of four transgressive-regressive cycles characterised by fluvial to tidal-influenced mixed clastic-carbonate and carbonate-dominated deposits, that locally show evidence of evaporite dissolution; highlighting that evaporite deposition started earlier than deposition of the regional South Atlantic Loeme-Bambata evaporite formations. Two separate pre-salt carbonate units have been differentiated within the Cangulo Fm; i) a lower transitional to marginal marine, and ii) a younger upper non-marine freshwater travertine system, that is documented for the first time in the west African margin. Transgressive-regressive cycles control the early diagenesis of the tidal carbonates that include dolomitization due to mixing fluids during transgressions, and karstification due to evaporite dissolution by meteoric water circulation during regressive events. Clastic supply appears to have been completely shut down during carbonate deposition, suggesting major climatic change associated with carbonate deposition. During the lowstand between the two carbonate units, fluid flow through Cangulo palaeovalley was re-established resulting in extensive karstification and formation of a large-scale erosional unconformity that is interpreted to be time equivalent to an intra Chela-Cuvo Fm. event. The top of the studied succession corresponds to the transgressive deposits of the Bambata evaporites that are not preserved in the Cangulo palaeovalley due to its erosion but are regionally developed. The results of this study can be directly linked to along strike age equivalent Pre-Salt successions cropping out in the Namibe, Benguela and Kwanza basins, and directly offshore Angola and Brazil using well and seismic data. These new data shed important new light and constraints on the depositional and diagenetic evolution of the complex Pre-Salt reservoir systems of the South Atlantic, and the depositional and bathymetric setting at the time of onset of the main south Atlantic evaporite deposition.publishedVersio

Postherpetic Neuralgia: Role of Gabapentin and Other Treatment Modalities

Postherpetic neuralgia (PHN) is a chronic and painful condition that may occur after a herpes zoster infection. The frequency of PHN after untreated zoster varies widely. Age is the most important risk factor for development of PHN. The condition occurs in an estimated 50% of patients older than 50 years. The pain of PHN can be severe and debilitating and is frequently associated with allodynia. Although in most patients pain remits within the first year, it may persist for a lifetime. Tricyclic antidepressants (TCAs), topical agents, opioids, and gabapentin, a structural Γ-amino butyric acid (GABA) analogue, are the only agents that have demonstrated efficacy in randomized clinical trials for treatment of both the shooting and the burning form of pain associated with PHN. TCAs are among the most commonly used classes of agents for treating PHN and are effective in a significant proportion of patients. However, various adverse events can limit treatment. These side effects tend to be more acute in the elderly, the population most likely to suffer from PHN. Topical agents have led to mild to moderate improvement in patients with PHN but are usually ineffective as monotherapy for this condition. Until recently, carbamazepine was the only antiepileptic drug evaluated for the treatment of PHN. Over the past few years, however, gabapentin has received increasing attention as a useful treatment for neuropathic pain. Gabapentin lacks significant drug-drug interactions and has a favorable safety profile, which makes it particularly useful for treatment of PHN.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65597/1/j.1528-1157.1999.tb00933.x.pd

Prevalence of microbiologically-confirmed influenza in patients with influenza-like illness in primary care and clinical and epidemiological characteristics

Objectives. We evaluated the prevalence of microbiologi-cally-confirmed influenza infection among patients with influ-enza-like symptoms and compared the clinical and epidemio-logical characteristics of patients with and without influenza infection. Methods. Retrospective study of a cohort of patients with influenza-like symptoms from 2016 to 2018 who partic-ipated in a clinical trial in thirteen urban primary centres in Catalonia. Different epidemiological data were collected. Patients rated the different symptoms and signs on a Likert scale (absent, little problem, moderate problem and severe problem) and self-reported the measure of health status with the Euro-Qol visual analogue scale. A nasopharyngeal swab was taken for microbiological isolation of influenza and other microor-ganisms. Results. A total of 427 patients were included. Micro-biologically confirmed influenza was found in 240 patients (56.2%). The percentage of patients with moderate-to-severe cough, muscle aches, tiredness and dizziness was greater among patients with microbiologically confirmed influenza. The self-reported health status was significantly lower among patients with true flu infection (mean of 36.3 ± 18.2 vs 41.7 ± 17.8 in patients without influenza; p<0.001). Conclusion. Clinical findings are not particularly useful for confirming or excluding the diagnosis of influenza when intensity is not considered. However, the presence of moder-ate-to-severe cough, myalgias, tiredness and dizziness along with a poor health status is more common in patients with confirmed flu infection

Communication, development, and social change in Spain: A field between institutionalization and implosion

This paper renders an account of the rapid institutionalization of the academic field of Communication for Development and Social Change (CDCS) in Spain in recent years following a period of neglect and marginalization. The ongoing expansion of the field of CDSC in the Spanish context is understood as a process of implosion, i.e. a collapse inwards, which results from the inconsistencies and weaknesses of fast and late institutionalization. The methodological approach for this inquiry is a documental review of both academic literature and research and institutional reports produced in Spain between 1980 and 2010. Based on this review, the paper contrasts the trajectory of the field in Spain with the debates at the international level, establishing relevant continuities and differences.This article is part of the Research Project (Ministry of Economy and Competitiveness, Spain) CSO2014-52005-R titled ‘Evaluation and Monitoring of Communication for Development and Social Change in Spain: design of indicators to measure its social impact’ (2015–2017)17 página