Synthesis, crystal structure and applications of palladium thiosalicylate complexes

AbstractThree palladium thiosalicylate complexes [Pd(tb)(bipy)]·3H2O (1), [Pd2(tb)2(bipy)2]·(dtdb)2 (2) and [Pd2(tb)2(phen)2]·dtdb·H2O (3) (bipy=bipyridine; phen=phenanthroline) were prepared from the reaction of PdCl2(CH3CN)2 with dithiosalicylic acid (dtdb) which underwent cleavage to form thiobenzoate anion (tb) in DMF/MeOH. Square planar geometries of the complexes with a N2SO coordination type were proposed on the basis of single crystal X-ray structural study. The presence of trapped and uncoordinated dtdb was observed in complexes 2 and 3. Complexes 1–3 were evaluated as catalysts for Heck coupling reactions of methyl acrylate with iodobenzene, and showed moderate activities at a very low catalyst loading. Complex 1 was found to inhibit the growth of bacteria and scavenge free radicals efficiently

Slow diffusion in situ ruthenium/ligand reaction: crystal structures, fluorescence and biological properties

Promoted by RuCl3·3H2O coordination in the mixed solvent DMF/H2O, diverse in situ S–S bond reactions such as S–S bond scission and S-oxidation occurred in the disulfide ligand of 2,2?-dithiodibenzoic acid (dtdb) to yield the new sulfinato-benzoate ligand (sb). The X-ray analysis of complexes of [Ru(phen)2(sb)] (1) and [Ru(bipy)2(sb)·H2O] (2) revealed that in both complexes, the ruthenium ion was found to be in an octahedral geometry, coordinating to the sulfur atom, rather than the oxygen of sulfinate. The complexes were found to be active against the bacterial strains tested with MIC ranging from 14.3–261 ?M. In addition, the metal complexes present strong DNA binding affinity constants in the major or minor grooves at the order of magnitude 105-106 M? 1. The antioxidant activities of the ligand and its metal complexes were investigated through scavenging effects for DPPH in vitro, indicating that the compounds show stronger activities than some standard antioxidants, such as ascorbic and vitamin C

Synthesis, crystal structure and applications of palladium thiosalicylate complexes

Three palladium thiosalicylate complexes [Pd(tb)(bipy)]·3H2O (1), [Pd2(tb)2(bipy)2]·(dtdb)2 (2) and [Pd2(tb)2(phen)2]·dtdb·H2O (3) (bipy = bipyridine; phen = phenanthroline) were prepared from the reaction of PdCl2(CH3CN)2 with dithiosalicylic acid (dtdb) which underwent cleavage to form thiobenzoate anion (tb) in DMF/MeOH. Square planar geometries of the complexes with a N2SO coordination type were proposed on the basis of single crystal X-ray structural study. The presence of trapped and uncoordinated dtdb was observed in complexes 2 and 3. Complexes 1–3 were evaluated as catalysts for Heck coupling reactions of methyl acrylate with iodobenzene, and showed moderate activities at a very low catalyst loading. Complex 1 was found to inhibit the growth of bacteria and scavenge free radicals efficiently