Palimpsest

Palimpsest Contributing artists: Ray Arnold, Christine Barry, Susan Fereday, David McDowell, Peter Mudie. Catalogue of an exhibition held at University Fine Arts Gallery, University of Tasmania, April 20-May 13, 1990 Kaye Moorhouse, curato

The status of military specifications with regard to atmospheric turbulence

The features of atmospheric disturbances that are significant to aircraft flying qualities are discussed. Next follows a survey of proposed models. Lastly, there is a discussion of the content and application of the model contained in the current flying qualities specification and the forthcoming MIL-Standard

A framework for the propagation of uncertainty in Transfer Path Analysis

Transfer Path Analysis (TPA) is a test-based methodology used to analyse the propagation of noise and vibration in complex systems. In this paper we present a covariance based framework for the propagation of experimental uncertainty in classical, blocked force, and component-based TPA procedures. The presence of both complex and correlated uncertainty is acknowledged through a bivariate description of the underlying uncertainty. The framework is summarised by a series of equations that propagate uncertainty through the various stages of a TPA procedure i.e. inverse source characterisation, dynamic sub-structuring, and forward response prediction. The uncertainty associated with rank ordering of source contributions is also addressed. To demonstrate the proposed framework a numerical simulation is presented, the results of which are compared against Monte-Carlo methods with good agreement obtained. An experimental study is also presented, where a blocked force TPA is performed on an electric steering system. The proposed uncertainty framework requires no additional experimental effort over and above what is performed in a standard TPA and may therefore be readily implemented into current TPA practices

Generalised round-trip identity — for the determination of structural dynamic properties at locations inaccessible or too distant for direct measurement

In noise and vibration engineering, a structure’s passive dynamic properties are often quantified by frequency response functions (FRFs). This paper focuses on acquiring FRFs from experimental tests, considering both, translational (x, y, z) and rotational (e.g. moments around these axes) terms. In practical applications, test structures may not allow FRFs to be measured directly due to the impracticality of applying a controlled excitation in a particular direction (e.g. in-plane), the inability to measure rotational dynamics (e.g. moment excitation), insufficient signal-to-noise ratio (SNR) between excitation and response degrees of freedom, or simply due to restricted access. Methods exist to resolve some of the mentioned issues using indirect experimental techniques, such as the round-trip identity. However, these methods are limited to cases in which the driving-point FRFs are sought-after. The present paper extends previous work into a more generalised formulation of the round-trip identity feasible for reconstructing driving-point and transfer mobilities from in-situ measurements conducted in coupled assemblies. By using the round-trip identity, the excitation of moments and/or inaccessible points is avoided altogether and instead replaced by a number of applied forces remote to the points of interest. Manipulation of this round-trip identity yields a formulation for long distance transfer FRFs, expressed in terms of multiple shorter transfer path elements, which are less prone to insufficient SNR. These practical applications of the generalised round-trip concept are experimentally validated for multi-input multi-output assemblies

Clonal evolution of Candida albicans, Candida glabrata and Candida dubliniensis at oral niche level in health and disease

This is the final version. Available on open access from Taylor & Francis via the DOI in this recordBackground:Candida species have long been recognised as aetiological agents of opportunistic infections of the oral mucosa, and more recently, as players of polymicrobial interactions driving caries, periodontitis and oral carcinogenesis. Methods: We studied the clonal structure of Candida spp. at oral niche resolution in patients (n = 20) with a range of oral health profiles over 22 months. Colonies from oral micro-environments were examined with multilocus sequencing typing. Results:Candida spp. identified were C. albicans, C. glabrata and C. dubliniensis. Increased propensity for micro-variations giving rise to multiple diploid strain types (DST), as a result of loss of heterozygosity, was observed among C. albicans clade 1 isolates compared to other clades. Micro-variations among isolates were also observed in C. dubliniensis contra to expectations of stable population structures for this species. Multiple sequence types were retrieved from patients without clinical evidence of oral candidosis, while single sequence types were isolated from oral candidosis patients. Conclusion: This is the first study to describe the clonal population structure, persistence and stability of Candida spp. at oral niche level. Future research investigating links between Candida spp. clonality and oral disease should recognise the propensity to micro-variations amongst oral niches in C. albicans and C. dubliniensis identified here.Medical Research Council (MRC)Wellcome Trus

Analytic Perturbation Theory: A New Approach to the Analytic Continuation of the Strong Coupling Constant αS\alpha_S into the Timelike Region

The renormalization group applied to perturbation theory is ordinarily used to define the running coupling constant in the spacelike region. However, to describe processes with timelike momenta transfers, it is important to have a self-consistent determination of the running coupling constant in the timelike region. The technique called analytic perturbation theory (APT) allows a consistent determination of this running coupling constant. The results are found to disagree significantly with those obtained in the standard perturbative approach. Comparison between the standard approach and APT is carried out to two loops, and threshold matching in APT is applied in the timelike region.Comment: 16 pages, REVTeX, 7 postscript figure

Chromatin particle spectrum analysis: a method for comparative chromatin structure analysis using paired-end mode next-generation DNA sequencing

Microarray and next-generation sequencing techniques which allow whole genome analysis of chromatin structure and sequence-specific protein binding are revolutionizing our view of chromosome architecture and function. However, many current methods in this field rely on biochemical purification of highly specific fractions of DNA prepared from chromatin digested with either micrococcal nuclease or DNaseI and are restricted in the parameters they can measure. Here, we show that a broad size-range of genomic DNA species, produced by partial micrococcal nuclease digestion of chromatin, can be sequenced using paired-end mode next-generation technology. The paired sequence reads, rather than DNA molecules, can then be size-selected and mapped as particle classes to the target genome. Using budding yeast as a model, we show that this approach reveals position and structural information for a spectrum of nuclease resistant complexes ranging from transcription factor-bound DNA elements up to mono- and poly-nucleosomes. We illustrate the utility of this approach in visualizing the MNase digestion landscape of protein-coding gene transcriptional start sites, and demonstrate a comparative analysis which probes the function of the chromatin-remodelling transcription factor Cbf1p

A systematic review of human evidence for the intergenerational effects of exposure to ionizing radiation

Supplemental material is available online at: https://www.tandfonline.com/doi/full/10.1080/09553002.2024.2306328#supplemental-material-section .Acknowledgements: The authors acknowledge Joanne Mcphie and Olwenn Martin for advising in the early stages of protocol development. The authors also thank Kirsty Lawrence and Ninoshka Barros for their support in elements of data extraction.Purpose: To provide a synthesis of the published evidence pertaining to the intergenerational health effects of parental preconceptional exposure to ionizing radiation in humans. Methods: The study populations are the descendants of those who were exposed to ionizing radiation prior to conception. A Boolean search identified publications for review in accordance with Office of Health Assessment and Translation guidelines. Initially, a risk of bias assessment was conducted for each published study and relevant data extracted. Information was organized into adverse health outcome groups and exposure situations. To make an assessment from the body of evidence within each group, an initial confidence rating was assigned, before factors including inconsistencies between studies, magnitude of effect, dose response and confounders were considered. From this, ‘an effect’, ‘no effect’ or whether the evidence remained ‘inadequate’ to determine either effect or no effect, was ascertained. This assessment was based primarily upon the author’s conclusions within that evidence-base and, by binomial probability testing of the direction of effect reported. Results: 2441 publications were identified for review which after screening was reduced to 127. For the majority of the adverse health groups, we find there to be inadequate evidence from which to determine whether the health effect was, or was not, associated with parental preconceptional radiation exposure. This was largely due to heterogeneity between individual study’s findings and conclusions within each group and, the limited number of studies within each group. We did observe one health grouping (congenital abnormalities) in occupationally exposed populations, where an increase in effect relative to their controls or large magnitude of effects, were reported, although it is noted that the authors of these studies interpreted their findings as most likely not to be associated with parental radiation exposure. Conclusions: We find there to be a lack of evidence to enable the formal assessment of radiation-related adverse effects in offspring of exposed humans. This is not the same as there being no clear evidence that effects may occur but does infer that if adverse health effects do arise in children of exposed parents, then these effects are small and difficult to reproducibly measure. Inconsistencies in designing studies are unavoidable, however we highlight the need for an element of standardization and, more sharing of primary datasets as part of open access initiatives, in order for future reviews to make reasonable conclusions. Overall, there is a need for future work to ensure comparable measures between studies where possible.This work was, in part, supported by the Nuclear Community Charity Fund (NCCF) through funds received by The Armed Forces Covenant Fund Trust under the Aged Veterans Fund Grant AVF16