Currently Seeking Revenge: How To Deal With An Awful Roommate

ROOMMATES: They’re the people you can talk to each night and rant about the day’s events, they tell you when you look nice and when your outfit is a complete mess. Or they can be the pesky people who scatter their shoes everywhere for you to trip on and leave moldy food in the fridge so a lovely smell wafts into your face every time you open the door. Here are some tips* to deal with the common annoyances a roommate offers

How Safe Are Your Snapchats?

We show you how to clean up your mess faster than you can screenshot your friend’s double-chin, cross-eyed Snapchat for blackmail. Snapchat is a self-destructing photo- and video-sharing app. The sender controls how long the receiver can see the photo or video by setting a timer for up to 10 seconds. After the allotted time, the content disappears into thin air forever—or so you thought

The Comeback Kid

The elusive events of one May night almost altered the rest of his life. Sexual assault charges loomed as his name appeared in media across the nation, prompting the community he grew up in to turn its back. Ethos reveals the man behind the dropped allegations

Progression for success: Evaluating North Yorkshire’s innovative careers guidance project

This report sets out the findings from an evaluation of North Yorkshires innovative careers guidance project.North Yorkshire County Counci

Spice Up Your Pregame

Pregame getting a little stale? Fear no more, we’ve compiled a list of drinking activities more exciting than the classic fall-back Ring of Fire to amp up your weekend (or week) nights

New Villagers

It was a gorgeous day in Dubrovnik, Croatia. Brooke Barker, senior in management and international business, kayaked to the Island of Lokrum, the wind blew through her hair as she paddled to keep up with the group. Upon reaching the island, she began the trek to the top, where she ran into some local daredevils preparing to jump into the deep blue water of the Adriatic Sea 35 feet below. Intrigued, Brooke decided to join them

Partial Reconstruction of the Ergot Alkaloid Pathway by Heterologous Gene Expression in Aspergillus nidulans

Ergot alkaloids are pharmaceutically and agriculturally important secondary metabolites produced by several species of fungi. Ergot alkaloid pathways vary among different fungal lineages, but the pathway intermediate chanoclavine-I is evolutionarily conserved among ergot alkaloid producers. At least four genes, dmaW, easF, easE, and easC, are necessary for pathway steps prior to chanoclavine-I; however, the sufficiency of these genes for chanoclavine-I synthesis has not been established. A fragment of genomic DNA containing dmaW, easF, easE, and easC was amplified from the human-pathogenic, ergot alkaloid-producing fungus Aspergillus fumigatus and transformed into Aspergillus nidulans, a model fungus that does not contain any of the ergot alkaloid synthesis genes. HPLC and LC-MS analyses demonstrated that transformed A. nidulans strains produced chanoclavine-I and an earlier pathway intermediate. Aspergillus nidulans transformants containing dmaW, easF, and either easE or easC did not produce chanoclavine-I but did produce an early pathway intermediate and, in the case of the easC transformant, an additional ergot alkaloid-like compound. We conclude that dmaW, easF, easE, and easC are sufficient for the synthesis of chanoclavine-I in A. nidulans and expressing ergot alkaloid pathway genes in A. nidulans provides a novel approach to understanding the early steps in ergot alkaloid synthesis

Gatsby careers benchmark north east implementation pilot: interim evaluation (2015-2017)

This report presents interim evaluation findings on the implementation of the Gatsby Benchmarks (herewith referred to as the Benchmarks) for good career guidance with a sample of 16 pilot schools and colleges (herewith referred to as education providers) in the North East of England. These interim findings report progress made against the Benchmarks during the course of the pilot (autumn 2015 to autumn 2017), the enablers and barriers faced, and the impact of the Benchmarks on learners’ career readiness and attainment. The interim findings suggest the following: Timescale - Schools and colleges involved were able to make significant strides towards fully meeting most, if not all, Benchmarks within two years. To date Benchmark 2 (Learning from career and labour market information) and Benchmark 7 (Encounters with FE and HE) have seen the largest increase in the number of pilot education providers fully achieving them. Benchmark 3 (Addressing the needs of every pupil) and Benchmark 4 (Linking curriculum to careers) have the least number of pilot education providers fully achieving them. Positive impact on learners. Learners show an increase in some aspects of career readiness and tentative increases in some aspects of GCSE attainment. Effective implementation of the Benchmarks. This was enabled by the existence of a regional facilitator to support pilot education providers and strong provider leadership and robust organisational infrastructures. Key barriers were a lack of time and space (in the curriculum), a lack of funding and a lack of commitment at senior leadership level, which impacted on achieving a cultural shift in some education providers. Regional impact. The implementation of the Benchmarks is impacting more widely in the region with non-pilot education providers forming links with pilot providers to seek support on developing good career guidance in their settings. Furthermore, wider stakeholders such as local employers and providers of careers education were also using the Benchmarks to review and develop their services to schools/colleges. Emerging challenges: A noticeable challenge was how the term ‘meaningful’, in relation to encounters with employers and employees, was interpreted and how education providers monitor provision of such encounters.Gatsby Charitable Foundatio

“Luteal Analgesia”: Progesterone Dissociates Pain Intensity and Unpleasantness by Influencing Emotion Regulation Networks

Background: Pregnancy-induced analgesia is known to occur in association with the very high levels of estradiol and progesterone circulating during pregnancy. In women with natural ovulatory menstrual cycles, more modest rises in these hormones occur on a monthly basis. We therefore hypothesized that the high estradiol high progesterone state indicative of ovulation would be associated with a reduction in the pain experience.Methods: We used fMRI and a noxious thermal stimulus to explore the relationship between sex steroid hormones and the pain experience. Specifically, we assessed the relationship with stimulus-related activity in key regions of networks involved in emotion regulation, and functional connectivity between these regions.Results: We demonstrate that physiologically high progesterone levels are associated with a reduction in the affective component of the pain experience and a dissociation between pain intensity and unpleasantness. This dissociation is related to decreased functional connectivity between the inferior frontal gyrus and amygdala. Moreover, we have shown that in the pre-ovulatory state, the traditionally “male” sex hormone, testosterone, is the strongest hormonal regulator of pain-related activity and connectivity within the emotional regulation network. However, following ovulation the traditionally “female” sex hormones, estradiol and progesterone, appear to dominate.Conclusions: We propose that a phenomenon of “luteal analgesia” exists with potential reproductive advantages