22 research outputs found

    The Theology of Mahayana Buddhism.

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    U.S. Foreign Policy and its Historical Development

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    This morning it is my duty and my privilege to discuss with you some of the major features of the United States Foreign Policy and to point out the historical development of some of these features

    The Theology of Mahayana Buddhism. (Concluded.)

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    From luther to Hittler : the history of fascist-nazi political philosophy

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    xiv, 683 p.; 22 cm

    Cardinal De Retz and the Fronde

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    Jungle paths and Inca ruins.

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    Photocopy.Mode of access: Internet.

    The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.

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    Infectious and inflammatory diseases have repeatedly shown strong genetic associations within the major histocompatibility complex (MHC); however, the basis for these associations remains elusive. To define host genetic effects on the outcome of a chronic viral infection, we performed genome-wide association analysis in a multiethnic cohort of HIV-1 controllers and progressors, and we analyzed the effects of individual amino acids within the classical human leukocyte antigen (HLA) proteins. We identified >300 genome-wide significant single-nucleotide polymorphisms (SNPs) within the MHC and none elsewhere. Specific amino acids in the HLA-B peptide binding groove, as well as an independent HLA-C effect, explain the SNP associations and reconcile both protective and risk HLA alleles. These results implicate the nature of the HLA-viral peptide interaction as the major factor modulating durable control of HIV infection
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