Etude de la variabilité inter- et intra-opérateur du volume de l'oreillette droite par l'IRM: travail de Bachelor

Nous avons réalisé un protocole de segmentation pour l’analyse de l’oreillette droite grâce au logiciel OsiriX dans le but de mesurer la variabilité inter- et intra-opérateur. Nous voulions vérifier si le TRM avait des résultats comparables à ceux d’un expert, le Professeur Vallée. Nous avons chacun effectué un certain nombre de segmentations pour calculer le volume de l’atrium droit. D’un point de vue médical, la mesure du volume de l’oreillette droite permet d’effectuer certains liens avec des pathologies

Prognostic value of transcriptional expression of fibronectin type III domain-containing 4 (FNDC4) in head and neck carcinoma patients treated with chemoradiotherapy

Purpose: FNDC4 gene encodes the fibronectin type III domain-containing 4 protein. Elevated expression of FNDC4 has been associated with poor prognosis in several types of cancer. There are no studies that have evaluated the prognostic capacity of FNDC4 in patients with head and neck cancer (HNSCC). The aim of our study was to analyze the relationship between the transcriptional expression of FNDC4 and prognosis in HNSCC patients. Methods: we determined the transcriptional expression of FNDC4 in 67 patients with advanced-stage HNSCC (III-IV) treated with chemoradiotherapy. The FNDC4 expression was categorized according to the disease-specific survival with a recursive partitioning analysis. Results: there were significant differences in disease-specific survival as a function of the level of FNDC4 transcriptional expression. The 5-year disease-specific survival for patients with high FNDC4 expression (n = 44, 65.7%) was 32.9% (95% CI: 16.5-49.3%), and for patients with low expression (n = 23, 34.3%) it was 85.4% (95% CI: 70.2-100%) (P = 0.0001). Patients with a high FNDC4 expression had poorer local (P = 0.097), regional (P = 0.008), and distant (0.034) recurrence-free survival. The results of a multivariate analysis showed that patients with a high FNDC4 expression had a 6.15-fold increased risk of death as a consequence of the HNSCC (95% CI: 1.71-22.06). Conclusion: FNCF4 transcriptional expression was significantly related to the disease-specific survival of HNSCC patients treated with chemoradiotherapy. Patients with elevated FNDC4 expression had a significant decrease in disease-specific survival

Avaliação da produção de biomassa por espécies adubadeiras arbóreas e gramíneas em um sistema agroflorestal.

Resumo: Em Sistemas Agroflorestais (SAF), além das culturas agrícolas de interesse comercial, há também espécies forrageiras, arbustivas, gramíneas e arbóreas destinadas à produção de biomassa. Devido à grande diversidade e complexidade, pouco se sabe sobre a produtividade das espécies e qual a área necessária ou número de indivíduos de cada espécie arbórea seria necessário para suprir a demanda nutricional do sistema. Para começar a responder essas questões, foi realizado o monitoramento da produção de biomassa e crescimento das espécies arbóreas mutambo (Guazuma ulmifolia L.), eucalipto (Eucalyptus urograndis) e da gramínea capim Mombaça (Megathyrsus maximus syn. Panicum maximum cv. Mombaça) em um modelo de SAF implantado na Embrapa Meio Ambiente, em Jaguariúna, SP. Considerando as arbóreas, o mutambo se destacou no crescimento e no fornecimento de biomassa, com taxas de crescimento médio de 32,6 ± 5,8 cm mês-1 em 15 meses e média acumulada de matéria seca para um indivíduo de 1,96 ± 0,74 kg, em 19 meses. Para o eucalipto, a taxa de crescimento e acúmulo de biomassa foram, respectivamente de 18,2 ± 11,7 cm mês-1 0,80 ± 0,75 kg. O capim Mombaça é capaz de fornecer biomassa rapidamente para um sistema recém implantado. Considerando cortes realizados após período majoritário de crescimento em meses chuvosos, a produtividade média do capim Mombaça no sistema foi de 6,3 ± 1,6 t ha-1 a cada corte, sendo a produtividade maior na porção das bordas quando comparada ao meio da entrelinha. -- Abstact: In Agroforestry Systems (AFS), in addition to agricultural commercial crops, there are also forage, shrub, grass and tree species intended for the production of green manure. Due to the great diversity and complexity, little information is available about the productivity of the species and what the required area or number of individual tree species would be necessary to supply the system's nutritional demand. To start answering these questions, the monitoring of green manure production and growth of the tree species Guazuma ulmifolia L., Eucalyptus urograndis and the grass Megathyrsus maximus syn. Panicum maximum cv. Mombasa was carried out in a ASF model at Embrapa Meio Ambiente, in Jaguariúna, SP. Considering trees, Guazuma ulmifolia L. showed average growth rates of 32.6 ± 5.8 cm/month in 15 months and an accumulated average dry matter for an individual of 1.96 ± 0.74 kg, in 19 months. For Eucalyptus urograndis, the growth rate and biomass accumulation were, respectively, 18.2 ± 11.7 cm/month 0.80 ± 0.75 kg. Megathyrsus maximus is capable of providing biomass quickly for a newly implanted system. Considering cuts made after a major period of growth in rainy months, the average productivity in the system was 6.3 ± 1.6 ton/ha at each cut, with higher productivity at the edges when compared to the middle of the line