Seasonal forecasts of the rainy season onset over Africa: Preliminary results from the FOCUS-Africa project

Precipitation seasonality is the main factor controlling vegetation phenology in many tropical and subtropical regions. Anticipating the rain onset is of paramount importance for field preparation and seeding. This is of particular importance in various African countries that rely on agriculture as a main source of food, subsistence and income. In such countries, skilful and accurate onset forecasts could also inform early warning and early actions, such as aids logistics planning, for food security. Here, we assess the skill of the seasonal forecast data provided by the Copernicus Climate Change Service in predicting the rain onset over Africa. The skill, i.e. the accuracy of the seasonal forecasts simulation ensemble compared to the climatology, is computed in a probabilistic fashion by accounting for the frequencies of normal, early and late onsets predicted by the forecast system. We compute the skill using the hindcasts (forecast simulations conducted for the past) starting at the beginning of each month in the period 1993–2016. We detect the onset timing of the rainy season using a non-parametric method that accounts for double seasonality and is suitable for the specific time-window of the seasonal forecast simulations. We find positive skills in some key African agricultural regions some months in advance. Overall, the multi-model ensemble outperforms any individual model ensemble. We provide targeted recommendations to develop a useful climate service for the agricultural sector in Africa

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

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El trabajo obtuvo un premio de la Modalidad B de los Premios Tomás García Verdejo a las buenas prácticas educativas de la Comunidad Autónoma de Extremadura para el curso académico 2014/2015Se describe un proyecto llevado a cabo en el IES Al-Qazares (Cáceres), en concreto en el Ciclo Formativo de Grado Superior de Integración Social, orientado a la sensibilización contra la violencia de género en la sociedad y en el centro. Entre los objetivos de la experiencia destacan: animar al alumnado a ser partícipe de sus propios aprendizajes fomentando una metodología basada en la investigación-acción, utilizar las tecnologías de la información y comunicación, desarrollar habilidades de trabajo en equipo y gestión de conflictos, fomentar la igualdad entre hombres y mujeres y aplicar la perspectiva de género en el desarrollo del trabajo diarioExtremaduraES