Adhesively-bonded GFRP-glass sandwich components for structurally efficient glazing applications

Composite sandwich structures made of thick glass face sheets adhesively-bonded to glass fibre-reinforced polymer (GFRP) core profiles have the potential to outperform existing non-composite glazing configurations but their feasibility has yet to be investigated and there are no analytical models that describe their structural response. This paper presents the new analytical models for predicting deflections and strains in adhesively-bonded GFRP-glass sandwich beams. The new analytical models successfully account for: the shear deformations of the core and adhesive layers; the local bending of the constituent parts about their centroidal axes; and the global bending of the sandwich component as a whole. The deflections and strains predicted by analytical models are validated by finite element simulations and compared with the results of destructive tests performed on adhesively-bonded GFRP-glass beams in a four-point bending configuration. The analytical models were also evaluated for alternative GFRP-glass configurations tested by others. The GFRP-glass beams specially assembled in this study confirm the physical feasibility of constructing these proposed components.The authors would like to thank the Engineering and Physical Sciences Research Council – United Kingdom for the financial support of the project

Knowledge-Based Engineering in the design for manufacture of prefabricated façades: current gaps and future trends

The use of prefabricated façades provides a timely means to increase efficiency in the delivery of buildings, while maximising the expected environmental service performance. In order to achieve high performance and low cost, these products require manufacturability and supply chain knowledge to be integrated earlier than usual in the design process. Knowledge-Based Engineering (KBE) applications can potentially fulfil this need by providing a digital Product Model that informs designers about manufacturability aspects and expected performance. This paper explores the currently-available digital tools, as well as KBE and its applicability in façade design. It is first demonstrated that there is a fundamental gap in state-of-the-art digital tools: rather than integrating design principles and manufacturing constraints, existing and emerging tools continue to focus on single-disciplines with no consideration for the actual manufacturing stage. The applicability of KBE is then evaluated by reviewing the current use of this approach in the building and other industries, namely, aerospace and shipbuilding. It is found that, although KBE is rarely used in facade design, there are significant opportunities for it to be applied in this sector, due to the similarity in terms of design tasks and priorities with the two other industries reviewed in this paper.The authors would like to thank the Engineering and Physical Science Research Council (EPSRC) and Laing O’Rourke Plc for supporting the present research programme

Knowledge-rich optimisation of prefabricated façades to support conceptual design

One of the principal challenges in façade design is to support the architectural intent by devising technically viable (i.e. standard-compliant and manufacturable) solutions from as early as possible in the design stage. This is increasingly relevant as prefabricated façades increase in complexity and bespokedness in response to current societal, financial and environmental challenges. In this paper a process that addresses this challenge is presented. The process consists of two sub-processes 1) to build product-oriented knowledge bases and digital tools for supporting design on a project-by-project basis and 2) to help designers identify a set of optimal solutions that consider the façade-specific trade-off between architectural intent and performance requirements, while meeting the largest number of production-related constraints. This process was applied to a case study and the results were compared with those obtained from a recently-developed façade. It was found that, although the proposed process produces optimal solutions that are approximated, designers can benefit from more control over the product’s manufacturability, performance and architectural intent in less time.Laing O'Rourke pl

Digitalized manufacturing logistics in engineer-to-order operations

This is a post-peer-review, pre-copyedit version of an article published in Advances in Production Management Systems. Production Management for the Factory of the Future. APMS 2019. IFIP Advances in Information and Communication Technology, vol. 566. The final authenticated version is available online at: https://doi.org/10.1007/978-3-030-30000-5_71. The high complexity in Engineer-To-Order (ETO) operations causes major challenges for manufacturing logistics, especially in complex ETO, i.e. one-of-a-kind production. Increased digitalization of manufacturing logistics processes and activities can facilitate more efficient coordination of the material and information flows for manufacturing operations in general. However, it is not clear how to do this in the ETO environment, where products are highly customized and production is non-repetitive. This paper aims to investigate the challenges related to manufacturing logistics in ETO and how digital technologies can be applied to address them. Through a case study of a Norwegian shipyard, four main challenges related to manufacturing logistics are identified. Further, by reviewing recent literature on ETO and digitalization, the paper identifies specific applications of digital technologies in ETO manufacturing. Finally, by linking manufacturing logistics challenges to digitalization, the paper suggests four main features of digitalized manufacturing logistics in ETO: (i) seamless, digitalized information flow, (ii) identification and interconnectivity, (iii) digitalized operator support, and (iv) automated and autonomous material flow. Thus, the paper provides valuable insights into how ETO companies can move towards digitalized manufacturing logistics

Ancient papillomavirus-host co-speciation in Felidae

The evolutionary rate of feline papillomaviruses is inferred from the phylogenetic analysis of their hosts, providing evidence for long-term virus-host co-speciatio

Compound double ileoileal and ileocecocolic intussusception caused by lipoma of the ileum in an adult patient: A case report

<p>Abstract</p> <p>Introduction</p> <p>The initial diagnosis of intussusception in adults very often can be missed and cause delayed treatment and possible serious complications. We report the case of an adult patient with complicated double ileoileal and ileocecocolic intussusception.</p> <p>Case presentation</p> <p>A 46-year-old Caucasian man was transferred from the gastroenterology service to the abdominal surgery service with severe abdominal pain, nausea, and vomiting. An abdominal ultrasound, barium enema, and abdominal computed tomography scan revealed an intraluminal obstruction of his ascending colon. Plain abdominal X-rays showed diffuse air-fluid levels in his small intestine. A double ileoileal and ileocecocolic intussusception was found during an emergent laparotomy. A right hemicolectomy, including resection of a long segment of his ileum, was performed. The postoperative period was complicated by acute renal failure, shock liver, and pulmonary thromboembolism. Our patient was discharged from the hospital after 30 days. An anatomical pathology examination revealed a lipoma of his ileum.</p> <p>Conclusions</p> <p>Intussusception in adults requires early surgical resection regardless of the nature of the initial cause. Delayed treatment can cause very serious complications.</p

Phase 2 study of canfosfamide in combination with pegylated liposomal doxorubicin in platinum and paclitaxel refractory or resistant epithelial ovarian cancer

<p>Abstract</p> <p>Background</p> <p>Canfosfamide is a novel glutathione analog activated by glutathione S-transferase P1-1. This study evaluated the safety and efficacy of canfosfamide in combination with pegylated liposomal doxorubicin (PLD) in patients with platinum resistant ovarian cancer. Patients with platinum resistant ovarian carcinoma and measurable disease received canfosfamide at 960 mg/m²in combination with PLD at 50 mg/m², intravenously day 1 in every 28 day cycles until tumor progression or unacceptable toxicities. The primary endpoints were objective response rate (ORR) and progression-free survival (PFS).</p> <p>Results</p> <p>Canfosfamide plus PLD combination therapy was administered at 960/50 mg/m², respectively. Thirty-nine patients received a median number of 4 cycles (range 1.0-18.0). The ORR was 27.8% (95% CI, 14.2-45.2) with a disease stabilization rate of 80.6% (95% CI, 64.0-91.8) in the evaluable population. The CA-125 marker responses correlated with the radiological findings of complete response or partial response. The median PFS was 6.0 months (95% CI, 4.2-7.9) and median survival was 17.8 months. The combination was well tolerated. Myelosuppression was managed with dose reductions and growth factor support. Grade 3 febrile neutropenia was observed in 2 patients (5.1%). Non-hematologic adverse events occurred at the expected frequency and grade for each drug alone, with no unexpected or cumulative toxicities.</p> <p>Conclusions</p> <p>Canfosfamide in combination with PLD is well tolerated and active in platinum and paclitaxel refractory or resistant ovarian cancer. A randomized phase 3 study was conducted based on this supportive phase 2 study.</p> <p>Trial Registration</p> <p>This study was registered at www.clinicaltrials.gov: NCT00052065.</p