The role of the immune system in brain metastasis

Metastatic brain tumors are the most common brain tumors in adults. With numerous successful advancements in systemic treatment of most common cancer types, brain metastasis is becoming increasingly important in the overall prognosis of cancer patients. Brain metastasis of peripheral tumor is the result of complex interplay of primary tumor, immune system and central nervous system microenvironment. Once formed, brain metastases hide behind the blood brain barrier and become inaccessible to chemotherapies that are otherwise successful in targeting systemic cancer. The approval of immune checkpoint inhibitors for several common cancers such as advanced melanoma and lung cancers brings with it the opportunity and obligation to further understand the mechanisms of immunosuppression by tumors that spread to the brain as well as the interaction between the brain environment and tumor microenvironment. In this review paper we define the central role of the immune system in the development of brain metastases. We performed a comprehensive review of the literature to outline the molecular mechanisms of immunosuppression used by tumors and how the immune system interacts with the central nervous system to facilitate brain metastasis. In particular we discuss the tumor-type-specific mechanisms of metastasis of cancers that preferentially metastasize to the brain as well as the therapies that effectively modulate the immune response, such as immune checkpoint inhibitors and vaccines

Magnetic Sensors Based on Long Josephson Tunnel Junctions - An Alternative to SQUIDs

The properties of Josephson devices are strongly affected by geometrical effects. A loop-shaped superconducting electrode tightly couples a long Josephson tunnel junction with the surrounding electromagnetic field. Due to the fluxoid conservation, any change of the magnetic flux linked to the loop results in a variation of the shielding current circulating around the loop, which, in turn, affects the critical current of the Josephson junction. This method allows the realization of a novel family of robust superconducting devices (not based on the quantum interference) which can function as a general-purpose magnetic sensors. The best performance is accomplished without compromising the noise performance by employing an in-line-type junction few times longer than its Josephson penetration length. The linear (rather than periodic) response to magnetic flux changes over a wide range is just one of its several advantages compared to the most sensitive magnetic detectors currently available, namely the Superconducting Quantum Interference Devices (SQUID). We will also comment on the drawbacks of the proposed system and speculate on its noise properties.Comment: 13 pages, 4 figure

High frequency acoustic modes in liquid gallium at the melting point

The microscopic dynamics in liquid gallium (l-Ga) at melting (T=315 K) has been studied by inelastic x-ray scattering. We demonstrate the existence of collective acoustic-like modes up to wave-vectors above one half of the first maximum of the static structure factor, at variance with earlier results from inelastic neutron scattering data [F.J. Bermejo et al. Phys. Rev. E 49, 3133 (1994)]. Despite the structural (an extremely rich polymorphism and rather complex phase diagram) and electronic (mixed valence) peculiarity of l-Ga, its collective dynamics is strikingly similar to the one of Van der Walls and alkali metals liquids. This result speaks in favor of the universality of the short time dynamics in monatomic liquids rather than of system-specific dynamics.Comment: LaTex format, 11 pages, 4 EncapsulatedPostScript figure

Defect formation in superconducting rings: external fields and finite-size effects

Consistent with the predictions of Kibble and Zurek, scaling behaviour has been seen in the production of fluxoids during temperature quenches of superconducting rings. However, deviations from the canonical behaviour arise because of finite-size effects and stray external fields. Technical developments, including laser heating and the use of long Josephson tunnel junctions, have improved the quality of data that can be obtained. With new experiments in mind we perform large-scale 3D simulations of quenches of small, thin rings of various geometries with fully dynamical electromagnetic fields, at nonzero externally applied magnetic flux. We find that the outcomes are, in practice, indistinguishable from those of much simpler Gaussian analytical approximations in which the rings are treated as one-dimensional systems and the magnetic field fluctuation-free.Comment: 10 pages, 3 figures, presentation at QFS2012, to appear in JLT

Chemical abundances of the metal-poor horizontal-branch stars CS 22186-005 and CS 30344-033

We report on a chemical-abundance analysis of two very metal-poor horizontal-branch stars in the Milky Way halo: CS 22186-005 ([Fe/H]=-2.70) and CS 30344-033 ([Fe/H]=-2.90). The analysis is based on high-resolution spectra obtained at ESO, with the spectrographs HARPS at the 3.6 m telescope, and UVES at the VLT. We adopted one-dimensional, plane-parallel model atmospheres assuming local thermodynamic equilibrium. We derived elemental abundances for 13 elements for CS 22186-005 and 14 elements for CS 30344-033. This study is the first abundance analysis of CS 30344-033. CS 22186-005 has been analyzed previously, but we report here the first measurement of nickel (Ni; Z = 28) for this star, based on twenty-two NiI lines ([Ni/Fe]=-0.21$\pm$0.02); the measurement is significantly below the mean found for most metal-poor stars. Differences of up to 0.5 dex in [Ni/Fe] ratios were determined by different authors for the same type of stars in the literature, which means that it is not yet possible to conclude that there is a real intrinsic scatter in the [Ni/Fe] ratios. For the other elements for which we obtained estimates, the abundance patterns in these two stars match the Galactic trends defined by giant and turnoff stars well. This confirms the value of horizontal-branch stars as tracers of the chemical properties of stellar populations in the Galaxy. Our radial velocities measurements for CS 22186-005 differ from previously published measurements by more than the expected statistical errors. More measurements of the radial velocity of this star are encouraged to confirm or refute its radial velocity variability

Constraining Cosmological Models by the Cluster Mass Function

We present a comparison between two observational and three theoretical mass functions for eight cosmological models suggested by the data from the recently completed BOOMERANG-98 and MAXIMA-1 cosmic microwave background (CMB) anisotropy experiments as well as peculiar velocities (PVs) and type Ia supernovae (SN) observations. The cosmological models have been proposed as the best fit models by several groups. We show that no model is in agreement with the abundances of X-ray clusters at $\sim 10^{14.7} h^{-1}M_{\odot}$.On the other hand, we find that the BOOM+MAX+{\sl COBE}:I, Refined Concordance and $\Lambda$MDM are in a good agreement with the abundances of optical clusters. The P11 and especially Concordance models predict a slightly lower abundances than observed at $\sim 10^{14.6} h^{-1}M_{\odot}$. The BOOM+MAX+{\sl COBE}:II and PV+CMB+SN models predict a slightly higher abundances than observed at $\sim 10^{14.9} h^{-1}M_{\odot}$. The nonflat MAXIMA-1 is in a fatal conflict with the observational cluster abundances and can be safely ruled out.Comment: 17 pages, 2 figures, reference added, figures changes, substantial revision mad

Evidence of anomalous dispersion of the generalized sound velocity in glasses

The dynamic structure factor, S(Q,w), of vitreous silica, has been measured by inelastic X-ray scattering in the exchanged wavevector (Q) region Q=4-16.5 nm-1 and up to energies hw=115 meV in the Stokes side. The unprecedented statistical accuracy in such an extended energy range allows to accurately determine the longitudinal current spectra, and the energies of the vibrational excitations. The simultaneous observation of two excitations in the acoustic region, and the persistence of propagating sound waves up to Q values comparable with the (pseudo-)Brillouin zone edge, allow to observe a positive dispersion in the generalized sound velocity that, around Q=5 nm-1, varies from 6500 to 9000 m/s: this phenomenon was never experimentally observed in a glass.Comment: 5 pages, 3 figures. To appear in Phys. Rev.

Temperature dependence of iron local magnetic moment in phase-separated superconducting chalcogenide

We have studied local magnetic moment and electronic phase separation in superconducting K$_{x}$Fe$_{2-y}$Se$_2$ by x-ray emission and absorption spectroscopy. Detailed temperature dependent measurements at the Fe K-edge have revealed coexisting electronic phases and their correlation with the transport properties. By cooling down, the local magnetic moment of Fe shows a sharp drop across the superconducting transition temperature (T$_c$) and the coexisting phases exchange spectral weights with the low spin state gaining intensity at the expense of the higher spin state. After annealing the sample across the iron-vacancy order temperature, the system does not recover the initial state and the spectral weight anomaly at T$_c$ as well as superconductivity disappear. The results clearly underline that the coexistence of the low spin and high spin phases and the transitions between them provide unusual magnetic fluctuations and have a fundamental role in the superconducting mechanism of electronically inhomogeneous K$_{x}$Fe$_{2-y}$Se$_2$ system.Comment: 6 pages, 5 figure