929 research outputs found
Cutting out the middleman: measuring nuclear area in histopathology slides without segmentation
The size of nuclei in histological preparations from excised breast tumors is
predictive of patient outcome (large nuclei indicate poor outcome).
Pathologists take into account nuclear size when performing breast cancer
grading. In addition, the mean nuclear area (MNA) has been shown to have
independent prognostic value. The straightforward approach to measuring nuclear
size is by performing nuclei segmentation. We hypothesize that given an image
of a tumor region with known nuclei locations, the area of the individual
nuclei and region statistics such as the MNA can be reliably computed directly
from the image data by employing a machine learning model, without the
intermediate step of nuclei segmentation. Towards this goal, we train a deep
convolutional neural network model that is applied locally at each nucleus
location, and can reliably measure the area of the individual nuclei and the
MNA. Furthermore, we show how such an approach can be extended to perform
combined nuclei detection and measurement, which is reminiscent of
granulometry.Comment: Conditionally accepted for MICCAI 201
Application of a knowledge-based ontology of the legal domain in collaborative workspaces
Informatie en Communicatie Technologie (ICT) en rech
Professional identity assignments to support beginning teachers’ growth into the profession
Developing a professional identity is a key element of the transition into the teaching profession. Limited research exists on professional development activities and ideas that support beginning teachers’ development of their professional identity in practice. For this study teachers participated in an induction programme that focused on beginning teachers’ professional identity. This study reports on the development and testing of three online professional identity assignments with 46 beginning teachers from 11 secondary schools. These assignments were based on research findings regarding the influence of ‘significant others’ and ‘stories to live by’ on teachers’ professional identity development. Analysis of the results reveals that the assignments each provide valuable input for doing identity work with beginning teachers in view of their further professional development. It can be concluded that the assignments we developed are useful for beginning teachers to reflect on and make sense of who they are and want to become
Juridische informatie is al toegankelijk
Effective Protection of Fundamental Rights in a pluralist worl
Het doemdenken van het CBP (Redactioneel)
De bescherming van fundamentele rechten in een integrerend Europ
Virtualization of dispute resolution. Establishing trust by recycling reputation
FDR Procesrecht en mediation -- ou
Maak wetgevingsproces eindelijk toegankelijk
FDR Regulering van internationaal economisch verkeer - ou
Applied legal epistemology. Building a knowledge-based ontology of the legal domain
Universiteit LeidenInformatie en Communicatie Technologie (ICT) en rech
Wet- en regelgeving februari 2009
Effective Protection of Fundamental Rights in a pluralist worl
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