Cutting out the middleman: measuring nuclear area in histopathology slides without segmentation

The size of nuclei in histological preparations from excised breast tumors is predictive of patient outcome (large nuclei indicate poor outcome). Pathologists take into account nuclear size when performing breast cancer grading. In addition, the mean nuclear area (MNA) has been shown to have independent prognostic value. The straightforward approach to measuring nuclear size is by performing nuclei segmentation. We hypothesize that given an image of a tumor region with known nuclei locations, the area of the individual nuclei and region statistics such as the MNA can be reliably computed directly from the image data by employing a machine learning model, without the intermediate step of nuclei segmentation. Towards this goal, we train a deep convolutional neural network model that is applied locally at each nucleus location, and can reliably measure the area of the individual nuclei and the MNA. Furthermore, we show how such an approach can be extended to perform combined nuclei detection and measurement, which is reminiscent of granulometry.Comment: Conditionally accepted for MICCAI 201

Application of a knowledge-based ontology of the legal domain in collaborative workspaces

Informatie en Communicatie Technologie (ICT) en rech

Professional identity assignments to support beginning teachers’ growth into the profession

Developing a professional identity is a key element of the transition into the teaching profession. Limited research exists on professional development activities and ideas that support beginning teachers’ development of their professional identity in practice. For this study teachers participated in an induction programme that focused on beginning teachers’ professional identity. This study reports on the development and testing of three online professional identity assignments with 46 beginning teachers from 11 secondary schools. These assignments were based on research findings regarding the influence of ‘significant others’ and ‘stories to live by’ on teachers’ professional identity development. Analysis of the results reveals that the assignments each provide valuable input for doing identity work with beginning teachers in view of their further professional development. It can be concluded that the assignments we developed are useful for beginning teachers to reflect on and make sense of who they are and want to become

Juridische informatie is al toegankelijk

Effective Protection of Fundamental Rights in a pluralist worl

Het doemdenken van het CBP (Redactioneel)

De bescherming van fundamentele rechten in een integrerend Europ

Virtualization of dispute resolution. Establishing trust by recycling reputation

FDR Procesrecht en mediation -- ou

Legitimacy and the virtualization of dispute resolution

FDR Procesrecht en mediation -- ou

Maak wetgevingsproces eindelijk toegankelijk

FDR Regulering van internationaal economisch verkeer - ou

Applied legal epistemology. Building a knowledge-based ontology of the legal domain

Universiteit LeidenInformatie en Communicatie Technologie (ICT) en rech

Wet- en regelgeving februari 2009

Effective Protection of Fundamental Rights in a pluralist worl