GRB 000301C: a possible short/intermediate duration burst connected to a DLA system

We discuss two main aspects of the GRB 000301C afterglow (Fynbo et al. 2000, Jensen et al. 2000); its short duration and its possible connection with a Damped Ly-alpha Absorber (DLA). GRB 000301C falls in the short class of bursts, though it is consistent with belonging to the proposed intermediate class or the extreme short end of the distribution of long-duration GRBs. Based on two VLT spectra we estimate the HI column density to be Log(N(HI))=21.2+/-0.5. This is the first direct indication of a connection between GRB host galaxies and Damped Ly-alpha Absorbers.Comment: 3 pages, 3 postscript figures. To appear in the proceedings of the October 2000 Rome Workshop on ``Gamma-Ray Bursts in the Afterglow Era'

VLT identification of the optical afterglow of the gamma-ray burst GRB 000131 at z=4.50

We report the discovery of the gamma-ray burst GRB 000131 and its optical afterglow. The optical identification was made with the VLT 84 hours after the burst following a BATSE detection and an Inter Planetary Network localization. GRB 000131 was a bright, long-duration GRB, with an apparent precursor signal 62 s prior to trigger. The afterglow was detected in ESO VLT, NTT, and DK1.54m follow-up observations. Broad-band and spectroscopic observations of the spectral energy distribution reveals a sharp break at optical wavelengths which is interpreted as a Ly-alpha absorption edge at 6700 A. This places GRB 000131 at a redshift of 4.500 +/- 0.015. The inferred isotropic energy release in gamma rays alone was approximately 10^54 erg (depending on the assumed cosmology). The rapid power-law decay of the afterglow (index alpha=2.25, similar to bursts with a prior break in the lightcurve), however, indicates collimated outflow, which relaxes the energy requirements by a factor of < 200. The afterglow of GRB 000131 is the first to be identified with an 8-m class telescope.Comment: 8 pages, 7 figures, accepted to A&A Letter

Organ Support Therapy in the Intensive Care Unit and Return to Work in Out-of-Hospital Cardiac Arrest Survivors:a Nationwide Cohort Study

AIM: With increased survival after out-of-hospital cardiac arrest (OHCA), impact of the post-resuscitation course has become important. Among 30-day OHCA survivors, we investigated associations between organ support therapy in the Intensive Care Unit (ICU) and return to work.METHODS: This Danish nationwide cohort-study included 30-day-OHCA-survivors who were employed prior to arrest. We linked OHCA data to information on in-hospital care and return to work. For patients admitted to an ICU and based on renal replacement therapy (RRT), cardiovascular support and mechanical ventilation, we assessed the prognostic value of organ support therapies in multivariable Cox regression models.RESULTS: Of 1,087 30-day survivors, 212 (19.5%) were treated in an ICU with 0-1 types of organ support, 494 (45.4%) with support of two organs, 26 (2.4%) with support of three organs and 355 (32.7%) were not admitted to an ICU. Return to work increased with decreasing number of organs supported, from 53.8% (95% CI: 49.5-70.1%) in patients treated with both RRT, cardiovascular support and mechanical ventilation to 88.5% (95% CI: 85.1-91.8%) in non-ICU-patients. In 732 ICU-patients, ICU-patients with support of 3 organs had significantly lower adjusted hazard ratios (HR) of returning to work (0.50 [95% CI: 0.30-0.85] compared to ICU-patients with support of 0-1 organ. The corresponding HR was 0.48 [95% CI: 0.30-0.78] for RRT alone.CONCLUSIONS: In 30-day survivors of OHCA, number of organ support therapies and in particular need of RRT were associated with reduced rate of return to work, although more than half of these latter patients still returned to work.</p

Multi-Wavelength Studies of the Optically Dark Gamma-Ray Burst 001025A

We identify the fading X-ray afterglow of GRB 001025A from XMM-Newton observations obtained 1.9-2.3 days, 2 years, and 2.5 years after the burst. The non-detection of an optical counterpart to an upper limit of R=25.5, 1.20 days after the burst, makes GRB 001025A a ``dark'' burst. Based on the X-ray afterglow spectral properties of GRB 001025A, we argue that some bursts appear optically dark because their afterglow is faint and their cooling frequency is close to the X-ray band. This interpretation is applicable to several of the few other dark bursts where the X-ray spectral index has been measured. The X-ray afterglow flux of GRB 001025A is an order of magnitude lower than for typical long-duration gamma-ray bursts. The spectrum of the X-ray afterglow can be fitted with an absorbed synchrotron emission model, an absorbed thermal plasma model, or a combination thereof. For the latter, an extrapolation to optical wavelengths can be reconciled with the R-band upper limit on the afterglow, without invoking any optical circumburst absorption, provided the cooling frequency is close to the X-ray band. Alternatively, if the X-ray afterglow is due to synchrotron emission only, seven magnitudes of extinction in the observed R-band is required to meet the R-band upper limit, making GRB 001025A much more obscured than bursts with detected optical afterglows. Based on the column density of X-ray absorbing circumburst matter, an SMC gas-to-dust ratio is insufficient to produce this amount of extinction. The X-ray tail of the prompt emission enters a steep temporal decay excluding that the tail of the prompt emission is the onset of the afterglow (abridged).Comment: 32 pages, 8 figures, ApJ in pres

On the Afterglow of the X-ray Flash of 2003 July 23: Photometric evdence for an Off-Axis Gamma-Ray burst with an Associated Supernova

Peer reviewe

Insulin and GH Signaling in Human Skeletal Muscle In Vivo following Exogenous GH Exposure: Impact of an Oral Glucose Load

GH induces acute insulin resistance in skeletal muscle in vivo, which in rodent models has been attributed to crosstalk between GH and insulin signaling pathways. Our objective was to characterize time course changes in signaling pathways for GH and insulin in human skeletal muscle in vivo following GH exposure in the presence and absence of an oral glucose load.Eight young men were studied in a single-blinded randomized crossover design on 3 occasions: 1) after an intravenous GH bolus 2) after an intravenous GH bolus plus an oral glucose load (OGTT), and 3) after intravenous saline plus OGTT. Muscle biopsies were taken at t = 0, 30, 60, and 120. Blood was sampled at frequent intervals for assessment of GH, insulin, glucose, and free fatty acids (FFA).GH increased AUC(glucose) after an OGTT (p<0.05) without significant changes in serum insulin levels. GH induced phosphorylation of STAT5 independently of the OGTT. Conversely, the OGTT induced acute phosphorylation of the insulin signaling proteins Akt (ser(473) and thr(308)), and AS160.The combination of OGTT and GH suppressed Akt activation, whereas the downstream expression of AS160 was amplified by GH. WE CONCLUDED THE FOLLOWING: 1) A physiological GH bolus activates STAT5 signaling pathways in skeletal muscle irrespective of ambient glucose and insulin levels 2) Insulin resistance induced by GH occurs without a distinct suppression of insulin signaling proteins 3) The accentuation of the glucose-stimulated activation of AS 160 by GH does however indicate a potential crosstalk between insulin and GH.ClinicalTrials.gov NCT00477997

Plasma immunoprofiling of patients with high-risk diffuse large B-cell lymphoma : a Nordic Lymphoma Group study

Non peer reviewe

A policy for diversity, equity, inclusion and anti-racism in the Scandinavian Society of Anaesthesiology and Intensive Care Medicine (SSAI)

Non peer reviewe