3,751 research outputs found
The Very Highly Ionized Broad Absorption Line System of the QSO SBS1542+541
We have analyzed the broad absorption line system of the bright (V=16.5)
high-redshift (z=2.361) QSO SBS1542+541 using UV spectra from the HST FOS along
with optical data from the MMT and the Steward Observatory 2.3m telescope.
These spectra give continuous wavelength coverage from 1200 to 8000 Angstroms,
corresponding to 340 to 2480 Angstroms in the QSO rest frame. This object
therefore offers a rare opportunity to study broad absorption lines in the
rest-frame extreme UV. We find that the absorption system is dominated by very
high-ionization species, including O VI, NeVIII, and SiXII. We also identify
apparently saturated broad Lyman-series lines of order Ly-gamma and higher.
There is strong evidence for partial occultation of the QSO emission source,
particularly from the higher-order Lyman lines which indicate a covered
fraction less than 0.2. Overall, the data suggest a correlation between a
larger covered fraction and a higher state of ionization. We suggest that the
different covered fractions can be explained by either a special line of sight
through a disk-like geometry or by the existence of density fluctuations of a
factor >2 in the BAL gas. Our photoionization models of the system indicate a
large column density and high ionization state similar to that found in X-ray
``warm absorbers''.Comment: 31 pages, 13 figures, to be published in Ap
First Results from the Large Area Lyman Alpha Survey
We report on a new survey for z=4.5 Lyman alpha sources, the Large Area Lyman
Alpha (LALA) survey. Our survey achieves an unprecedented combination of volume
and sensitivity by using narrow-band filters on the new 8192x8192 pixel CCD
Mosaic Camera at the 4 meter Mayall telescope of Kitt Peak National
Observatory.
Well-detected sources with flux and equivalent width matching known high
redshift Lyman alpha galaxies (i.e., observed equivalent width above 80
Angstroms and line+continuum flux between 2.6e-17 and 5.2e-17 erg/cm^2/sec in
an 80 Angstrom filter) have an observed surface density corresponding to 11000
+- 700 per square degree per unit redshift at z=4.5. Spatial variation in this
surface density is apparent on comparison between counts in 6561 and 6730
Angstrom filters.
Early spectroscopic followup results from the Keck telescope included three
sources meeting our criteria for good Lyman alpha candidates. Of these, one is
confirmed as a z=4.52 source, while another remains consistent with either
z=4.55 or z=0.81. We infer that 30 to 50% of our good candidates are bona fide
Lyman alpha emitters, implying a net density of about 4000 Lyman alpha galaxies
per square degree per unit redshift.Comment: 10 pages, 2 figures (3 .ps files), uses AASTeX 4. Submitted to The
Astrophysical Journal Letter
Natural products improve healthspan in aged mice and rats: a systematic review and meta-analysis
Over the last decades a decrease in mortality has paved the way for late onset pathologies such as cardiovascular, metabolic or neurodegenerative diseases. This evidence has led many researchers to shift their focus from researching ways to extend lifespan to finding ways to increase the number of years spent in good health; âhealthspanâ is indeed the emerging concept of such quest for ageing without chronic or disabling diseases and dysfunctions. Regular consumption of natural products might improve healthspan, although the mechanisms of action are still poorly understood. Since preclinical studies aimed to assess the efficacy and safety of these compounds are growing, we performed a systematic review and meta-analysis on the effects of natural products on healthspan in mouse and rat models of physiological ageing. Results indicate that natural compounds show robust effects improving stress resistance and cognitive abilities. These promising data call for further studies investigating the underlying mechanisms in more depth
Horizontal force production and multi-segment foot kinematics during the acceleration phase of bend sprinting
This paper investigated horizontal force production, foot kinematics and metatarsophalangeal (MTP) joint push-off axis use during acceleration in bend (anti-clockwise) and straight-line sprinting. It was hypothesised that bend sprinting would cause the left step push-off to occur about the oblique axis, resulting in a decrease in propulsive force. Three-dimensional kinematic and ground reaction force data were collected from nine participants during sprinting on the bend (36.5 m radius) and straight. Anteroposterior force was reduced at 38-44% of stance during bend sprinting compared with the straight. This coincided with an increase in mediolateral force for the majority of the stance phase (3-96%) on the bend compared with the straight. In addition, a lower propulsive impulse was reported on the bend compared with the straight. Analysis of multi-segment foot kinematics provides insight into the possible mechanisms behind these changes in force production. Mean mediolateral centre of pressure position was more lateral in relation to the second metatarsal head in the left step on the bend compared with the straight, indicating the oblique axis was used for push-off at the MTP joint. Greater peak joint angles of the left foot were also reported, in particular, an increase in left step midfoot eversion and internal ankle rotation. It is possible these changes in joint kinematics are associated with the observed decrease in propulsive force. Therefore, practitioners should seek to strengthen muscles such as tibialis posterior in frontal and sagittal planes and ensure specificity of training which may aid in addressing these force reductions
Comparison of pharmacodynamics of azithromycin and erythromycin in vitro and in vivo
In this study, we determined the efficacy of various dosing regimens for
erythromycin and azithromycin against four pneumococci with different
susceptibilities to penicillin in an in vitro pharmacokinetic model and in
a mouse peritonitis model. The MIC was 0.03 microg/ml, and the 50%
effective doses (determined after one dose) of both drugs were comparable
for the four pneumococcal strains and were in the range of 1.83 to 6.22
mg/kg. Dosing experiments with mice, using regimens for azithromycin of
one to eight doses/6 h, showed the one-dose regimen to give the best
result; of the pharmacodynamic parameters tested (the maximum drug
concentration in serum [Cmax], the times that the drug concentration in
serum remained above the MIC and above the concentration required for
maximum killing, and the area under the concentration time curve), Cmax
was the best predictor of outcome. The bacterial counts in mouse blood or
peritoneal fluid during the first 24 h after challenge were not correlated
to survival of the mice. The serum concentration profiles obtained with
mice for the different dosing regimens were simulated in the in vitro
pharmacokinetic model. Here as well, the one-dose regimen of azithromycin
showed the best result. However, the killing curves in vivo in mouse blood
and peritoneal fluid and in the vitro pharmacokinetic model were not
similar. The in vitro killing curves showed a decrease of 2 log10 within 2
and 3 h for azithromycin and erythromycin, respectively whereas the in
vivo killing curves showed a bacteriostatic effect for both drugs. It is
concluded that the results in terms of predictive pharmacodynamic
parameters are comparable for the in vitro and in vivo models and that
high initial concentrations of azithromycin favor a good outcome
Masses of Multiquark Droplets
The mass formulae for finite lumps of strange quark matter with , and
quarks, and non-strange quark matter consisting of and quarks are
derived in a non-relativistic potential model. The finite-size effects
comprising the surface, curvature and even, the Gauss curvature were
consistently obtained, which shows a converging trend. It is found that there
is a possibility for the formation of metastable strangelets of large mass. The
model predicts low charge to mass ratio as the characteristic signature of
strange matter in agreement with the relativistic studies. This study also
yields an independent estimate for the bag energy density , which is in
agreement with the M.I.T bag model value.Comment: 24pages + 5 figures available upon request,Latex,IP/BBSR/93-3
VLT identification of the optical afterglow of the gamma-ray burst GRB 000131 at z=4.50
We report the discovery of the gamma-ray burst GRB 000131 and its optical
afterglow. The optical identification was made with the VLT 84 hours after the
burst following a BATSE detection and an Inter Planetary Network localization.
GRB 000131 was a bright, long-duration GRB, with an apparent precursor signal
62 s prior to trigger. The afterglow was detected in ESO VLT, NTT, and DK1.54m
follow-up observations. Broad-band and spectroscopic observations of the
spectral energy distribution reveals a sharp break at optical wavelengths which
is interpreted as a Ly-alpha absorption edge at 6700 A. This places GRB 000131
at a redshift of 4.500 +/- 0.015. The inferred isotropic energy release in
gamma rays alone was approximately 10^54 erg (depending on the assumed
cosmology). The rapid power-law decay of the afterglow (index alpha=2.25,
similar to bursts with a prior break in the lightcurve), however, indicates
collimated outflow, which relaxes the energy requirements by a factor of < 200.
The afterglow of GRB 000131 is the first to be identified with an 8-m class
telescope.Comment: 8 pages, 7 figures, accepted to A&A Letter
Structural and evolutionary relationships among protein tyrosine phosphatase domains
With the current access to the whole genomes of various organisms and the completion of the first draft of the human genome, there is a strong need for a structure-function classification of protein families as an initial step in moving from DNA databases to a comprehensive understanding of human biology. As a result of the explosion in nucleic acid sequence information and the concurrent development of methods for high-throughput functional characterization of gene products, the genomic revolution also promises to provide a new paradigm for drug discovery, enabling the identification of molecular drug targets in a significant number of human diseases. This molecular view of diseases has contributed to the importance of combining primary sequence data with three-dimensional structure and has increased the awareness of computational homology modeling and its potential to elucidate protein function. In particular, when important proteins or novel therapeutic targets are identifiedâlike the family of protein tyrosine phosphatases (PTPs) (reviewed in reference 53)âa structure-function classification of such protein families becomes an invaluable framework for further advances in biomedical science. Here, we present a comparative analysis of the structural relationships among vertebrate PTP domains and provide a comprehensive resource for sequence analysis of phosphotyrosine-specific PTPs
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