Association of Candidate Gene Polymorphisms With Chronic Kidney Disease: Results of a Case-Control Analysis in the Nefrona Cohort

Chronic kidney disease (CKD) is a major risk factor for end-stage renal disease, cardiovascular disease and premature death. Despite classical clinical risk factors for CKD and some genetic risk factors have been identified, the residual risk observed in prediction models is still high. Therefore, new risk factors need to be identified in order to better predict the risk of CKD in the population. Here, we analyzed the genetic association of 79 SNPs of proteins associated with mineral metabolism disturbances with CKD in a cohort that includes 2, 445 CKD cases and 559 controls. Genotyping was performed with matrix assisted laser desorption ionizationtime of flight mass spectrometry. We used logistic regression models considering different genetic inheritance models to assess the association of the SNPs with the prevalence of CKD, adjusting for known risk factors. Eight SNPs (rs1126616, rs35068180, rs2238135, rs1800247, rs385564, rs4236, rs2248359, and rs1564858) were associated with CKD even after adjusting by sex, age and race. A model containing five of these SNPs (rs1126616, rs35068180, rs1800247, rs4236, and rs2248359), diabetes and hypertension showed better performance than models considering only clinical risk factors, significantly increasing the area under the curve of the model without polymorphisms. Furthermore, one of the SNPs (the rs2248359) showed an interaction with hypertension, being the risk genotype affecting only hypertensive patients. We conclude that 5 SNPs related to proteins implicated in mineral metabolism disturbances (Osteopontin, osteocalcin, matrix gla protein, matrix metalloprotease 3 and 24 hydroxylase) are associated to an increased risk of suffering CKD

First Latin American clinical practice guidelines for the treatment of systemic lupus erythematosus: Latin American Group for the Study of Lupus (GLADEL, Grupo Latino Americano de Estudio del Lupus)-Pan-American League of Associations of Rheumatology (PANLAR)

Systemic lupus erythematosus (SLE), a complex and heterogeneous autoimmune disease, represents a significant challenge for both diagnosis and treatment. Patients with SLE in Latin America face special problems that should be considered when therapeutic guidelines are developed. The objective of the study is to develop clinical practice guidelines for Latin American patients with lupus. Two independent teams (rheumatologists with experience in lupus management and methodologists) had an initial meeting in Panama City, Panama, in April 2016. They selected a list of questions for the clinical problems most commonly seen in Latin American patients with SLE. These were addressed with the best available evidence and summarised in a standardised format following the Grading of Recommendations Assessment, Development and Evaluation approach. All preliminary findings were discussed in a second face-to-face meeting in Washington, DC, in November 2016. As a result, nine organ/system sections are presented with the main findings; an 'overarching' treatment approach was added. Special emphasis was made on regional implementation issues. Best pharmacologic options were examined for musculoskeletal, mucocutaneous, kidney, cardiac, pulmonary, neuropsychiatric, haematological manifestations and the antiphospholipid syndrome. The roles of main therapeutic options (ie, glucocorticoids, antimalarials, immunosuppressant agents, therapeutic plasma exchange, belimumab, rituximab, abatacept, low-dose aspirin and anticoagulants) were summarised in each section. In all cases, benefits and harms, certainty of the evidence, values and preferences, feasibility, acceptability and equity issues were considered to produce a recommendation with special focus on ethnic and socioeconomic aspects. Guidelines for Latin American patients with lupus have been developed and could be used in similar settings.Fil: Pons Estel, Bernardo A.. Centro Regional de Enfermedades Autoinmunes y Reumáticas; ArgentinaFil: Bonfa, Eloisa. Universidade de Sao Paulo; BrasilFil: Soriano, Enrique R.. Instituto Universitario Hospital Italiano de Buenos Aires. Rectorado.; ArgentinaFil: Cardiel, Mario H.. Centro de Investigación Clínica de Morelia; MéxicoFil: Izcovich, Ariel. Hospital Alemán; ArgentinaFil: Popoff, Federico. Hospital Aleman; ArgentinaFil: Criniti, Juan M.. Hospital Alemán; ArgentinaFil: Vásquez, Gloria. Universidad de Antioquia; ColombiaFil: Massardo, Loreto. Universidad San Sebastián; ChileFil: Duarte, Margarita. Hospital de Clínicas; ParaguayFil: Barile Fabris, Leonor A.. Hospital Angeles del Pedregal; MéxicoFil: García, Mercedes A.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Amigo, Mary Carmen. Centro Médico Abc; MéxicoFil: Espada, Graciela. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; ArgentinaFil: Catoggio, Luis J.. Hospital Italiano. Instituto Universitario. Escuela de Medicina; ArgentinaFil: Sato, Emilia Inoue. Universidade Federal de Sao Paulo; BrasilFil: Levy, Roger A.. Universidade do Estado de Rio do Janeiro; BrasilFil: Acevedo Vásquez, Eduardo M.. Universidad Nacional Mayor de San Marcos; PerúFil: Chacón Díaz, Rosa. Policlínica Méndez Gimón; VenezuelaFil: Galarza Maldonado, Claudio M.. Corporación Médica Monte Sinaí; EcuadorFil: Iglesias Gamarra, Antonio J.. Universidad Nacional de Colombia; ColombiaFil: Molina, José Fernando. Centro Integral de Reumatología; ColombiaFil: Neira, Oscar. Universidad de Chile; ChileFil: Silva, Clóvis A.. Universidade de Sao Paulo; BrasilFil: Vargas Peña, Andrea. Hospital Pasteur Montevideo; UruguayFil: Gómez Puerta, José A.. Hospital Clinic Barcelona; EspañaFil: Scolnik, Marina. Instituto Universitario Hospital Italiano de Buenos Aires. Rectorado.; ArgentinaFil: Pons Estel, Guillermo J.. Centro Regional de Enfermedades Autoinmunes y Reumáticas; Argentina. Hospital Provincial de Rosario; ArgentinaFil: Ugolini Lopes, Michelle R.. Universidade de Sao Paulo; BrasilFil: Savio, Verónica. Instituto Universitario Hospital Italiano de Buenos Aires. Rectorado.; ArgentinaFil: Drenkard, Cristina. University of Emory; Estados UnidosFil: Alvarellos, Alejandro J.. Hospital Privado Universitario de Córdoba; ArgentinaFil: Ugarte Gil, Manuel F.. Universidad Cientifica del Sur; Perú. Hospital Nacional Guillermo Almenara Irigoyen; PerúFil: Babini, Alejandra. Instituto Universitario Hospital Italiano de Buenos Aires. Rectorado.; ArgentinaFil: Cavalcanti, André. Universidade Federal de Pernambuco; BrasilFil: Cardoso Linhares, Fernanda Athayde. Hospital Pasteur Montevideo; UruguayFil: Haye Salinas, Maria Jezabel. Hospital Privado Universitario de Córdoba; ArgentinaFil: Fuentes Silva, Yurilis J.. Universidad de Oriente - Núcleo Bolívar; VenezuelaFil: Montandon De Oliveira E Silva, Ana Carolina. Universidade Federal de Goiás; BrasilFil: Eraso Garnica, Ruth M.. Universidad de Antioquia; ColombiaFil: Herrera Uribe, Sebastián. Hospital General de Medellin Luz Castro de Gutiérrez; ColombiaFil: Gómez Martín, DIana. Instituto Nacional de la Nutrición Salvador Zubiran; MéxicoFil: Robaina Sevrini, Ricardo. Universidad de la República; UruguayFil: Quintana, Rosana M.. Hospital Provincial de Rosario; Argentina. Centro Regional de Enfermedades Autoinmunes y Reumáticas; ArgentinaFil: Gordon, Sergio. Hospital Interzonal General de Agudos Dr Oscar Alende. Unidad de Reumatología y Enfermedades Autoinmunes Sistémicas; ArgentinaFil: Fragoso Loyo, Hilda. Instituto Nacional de la Nutrición Salvador Zubiran; MéxicoFil: Rosario, Violeta. Hospital Docente Padre Billini; República DominicanaFil: Saurit, Verónica. Hospital Privado Universitario de Córdoba; ArgentinaFil: Appenzeller, Simone. Universidade Estadual de Campinas; BrasilFil: Dos Reis Neto, Edgard Torres. Universidade Federal de Sao Paulo; BrasilFil: Cieza, Jorge. Hospital Nacional Edgardo Rebagliati Martins; PerúFil: González Naranjo, Luis A.. Universidad de Antioquia; ColombiaFil: González Bello, Yelitza C.. Ceibac; MéxicoFil: Collado, María Victoria. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Sarano, Judith. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Retamozo, Maria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Sattler, María E.. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; ArgentinaFil: Gamboa Cárdenas, Rocio V.. Hospital Nacional Guillermo Almenara Irigoyen; PerúFil: Cairoli, Ernesto. Universidad de la República; UruguayFil: Conti, Silvana M.. Hospital Provincial de Rosario; ArgentinaFil: Amezcua Guerra, Luis M.. Instituto Nacional de Cardiologia Ignacio Chavez; MéxicoFil: Silveira, Luis H.. Instituto Nacional de Cardiologia Ignacio Chavez; MéxicoFil: Borba, Eduardo F.. Universidade de Sao Paulo; BrasilFil: Pera, Mariana A.. Hospital Interzonal General de Agudos General San Martín; ArgentinaFil: Alba Moreyra, Paula B.. Universidad Nacional de Córdoba. Facultad de Medicina; ArgentinaFil: Arturi, Valeria. Hospital Interzonal General de Agudos General San Martín; ArgentinaFil: Berbotto, Guillermo A.. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; ArgentinaFil: Gerling, Cristian. Hospital Interzonal General de Agudos Dr Oscar Alende. Unidad de Reumatología y Enfermedades Autoinmunes Sistémicas; ArgentinaFil: Gobbi, Carla Andrea. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gervasoni, Viviana L.. Hospital Provincial de Rosario; ArgentinaFil: Scherbarth, Hugo R.. Hospital Interzonal General de Agudos Dr Oscar Alende. Unidad de Reumatología y Enfermedades Autoinmunes Sistémicas; ArgentinaFil: Brenol, João C. Tavares. Hospital de Clinicas de Porto Alegre; BrasilFil: Cavalcanti, Fernando. Universidade Federal de Pernambuco; BrasilFil: Costallat, Lilian T. Lavras. Universidade Estadual de Campinas; BrasilFil: Da Silva, Nilzio A.. Universidade Federal de Goiás; BrasilFil: Monticielo, Odirlei A.. Hospital de Clinicas de Porto Alegre; BrasilFil: Seguro, Luciana Parente Costa. Universidade de Sao Paulo; BrasilFil: Xavier, Ricardo M.. Hospital de Clinicas de Porto Alegre; BrasilFil: Llanos, Carolina. Universidad Católica de Chile; ChileFil: Montúfar Guardado, Rubén A.. Instituto Salvadoreño de la Seguridad Social; El SalvadorFil: Garcia De La Torre, Ignacio. Hospital General de Occidente; MéxicoFil: Pineda, Carlos. Instituto Nacional de Rehabilitación; MéxicoFil: Portela Hernández, Margarita. Umae Hospital de Especialidades Centro Medico Nacional Siglo Xxi; MéxicoFil: Danza, Alvaro. Hospital Pasteur Montevideo; UruguayFil: Guibert Toledano, Marlene. Medical-surgical Research Center; CubaFil: Reyes, Gil Llerena. Medical-surgical Research Center; CubaFil: Acosta Colman, Maria Isabel. Hospital de Clínicas; ParaguayFil: Aquino, Alicia M.. Hospital de Clínicas; ParaguayFil: Mora Trujillo, Claudia S.. Hospital Nacional Edgardo Rebagliati Martins; PerúFil: Muñoz Louis, Roberto. Hospital Docente Padre Billini; República DominicanaFil: García Valladares, Ignacio. Centro de Estudios de Investigación Básica y Clínica; MéxicoFil: Orozco, María Celeste. Instituto de Rehabilitación Psicofísica; ArgentinaFil: Burgos, Paula I.. Pontificia Universidad Católica de Chile; ChileFil: Betancur, Graciela V.. Instituto de Rehabilitación Psicofísica; ArgentinaFil: Alarcón, Graciela S.. Universidad Peruana Cayetano Heredia; Perú. University of Alabama at Birmingahm; Estados Unido

FIGURE 11 in Morphological revision of the Subgroup 1 Fauchald, 1970 of Marphysa de Quatrefages, 1865 (Eunicidae: Polychaeta)

FIGURE 11. Paucibranchia bellii (Audouin & Milne-Edwards, 1833) n. comb. A. Anterior end, dorsal view; B. Anterior end, ventral view; C. Anterior end with branchiae, dorsal view; D. Pygidium, ventral view. A–C from lectotype MNHN TYPE 568; D from non-type ECOSUR–P2173. Scale bars: A, B, D, 1 mm; C, 2 mm

FIGURE 12 in Morphological revision of the Subgroup 1 Fauchald, 1970 of Marphysa de Quatrefages, 1865 (Eunicidae: Polychaeta)

FIGURE 12. Paucibranchia bellii (Audouin & Milne-Edwards, 1833) n. comb. A. Maxillary apparatus, dorsal view; B. Maxillary apparatus, dorsal view; C. Left MI-II-III-IV-V; D. Right MI-II-IV-V. A from lectotype MNHN TYPE 568, B, C, D, from non-type ECOSUR–P2173. Scale bars: A, 0.2 mm; B, 0.7 mm, C, D, 0.3 mm

FIGURE 29 in Morphological revision of the Subgroup 1 Fauchald, 1970 of Marphysa de Quatrefages, 1865 (Eunicidae: Polychaeta)

FIGURE 29. Paucibranchia disjuncta (Hartman, 1961) n. comb. A. Compound spinigers, chaetiger 55; B. Compound falciger, chaetiger 115; C. Isodonts pectinate narrow with long and slender teeth, chaetiger 3; D. Isodonts pectinate narrow with long and slender teeth, chaetiger 6; E. Isodonts pectinate narrow with short and slender teeth, chaetiger 65; F. Subacicular hook bidentante, chaetiger 55; G. Subacicular unidentate with hood, chaetiger 47. A, D, E, G, from non-type LACM-AHF POLY 10195; B from holotype LACM-AHF POLY 724; C from non-type LACM-AHF POLY 10196; F from non-type LACM-AHF POLY6948. Scale bars: A, B, 20 µm; C, 14 µm; D, E, G, 10 µm; F, 20 µm

FIGURE 9. Paucibranchia andresi n in Morphological revision of the Subgroup 1 Fauchald, 1970 of Marphysa de Quatrefages, 1865 (Eunicidae: Polychaeta)

FIGURE 9. Paucibranchia andresi n. sp., holotype USNM 28955. A. Parapodium 3; B. Parapodium 8; C. Parapodium 14; D. Parapodium 55; E. Parapodium 213. All in anterior view. Scale bars: A, 0.17 mm; B, D, E, 0.2 mm; C, 0.4 mm

Reinstatement of species belonging Marphysa sanguinea complex (Annelida Eunicidae) and description of new species from the mid-Pacific Ocean and the Adriatic Sea

Molina-Acevedo, Isabel C., Idris, Izwandy (2020): Reinstatement of species belonging Marphysa sanguinea complex (Annelida Eunicidae) and description of new species from the mid-Pacific Ocean and the Adriatic Sea. Zootaxa 4816 (1): 1-48, DOI: https://doi.org/10.11646/zootaxa.4816.1.

Reinstatement of three species of the Marphysa sanguinea complex (Polychaeta: Eunicidae) from the Grand Caribbean Region

Molina-Acevedo, Isabel C., Carrera-Parra, Luis F. (2015): Reinstatement of three species of the Marphysa sanguinea complex (Polychaeta: Eunicidae) from the Grand Caribbean Region. Zootaxa 3925 (1): 37-55, DOI: http://dx.doi.org/10.11646/zootaxa.3925.1.

LISTA DE ESPECIES Y ESTADO DE CONOCIMIENTO DE LOS POLIQUETOS (ANNELIDA: POLYCHAETA) DE SINALOA, GOLFO DE CALIFORNIA

RESUMEN: Sinaloa es un estado mexicano ubicado en el sureste del golfo de California, representado por una amplia biodiversidad de macroinvertebrados, entre ellos, los poliquetos. Este grupo es muy diverso en el estado; sin embargo, la información sobre los registros de las especies se encuentra dispersa en numerosas fuentes. La presencia de poliquetos aparentemente cosmopolitas en el Pacífico oriental tropical (POT) es alta; por tanto, es probable que numerosas especies sean cuestionables para Sinaloa. La finalidad del presente estudio fue recopilar el nombre de todas las especies de poliquetos conocidas para el estado en la actualidad, incluyendo la distribución batimétrica y una evaluación de su distribución en la región zoogeográfica POT. Se realizó una búsqueda exhaustiva de la literatura para compilar los registros de especies de poliquetos, en el estado hasta el 2014, se indicó la distribución batimétrica y la localidad tipo. El análisis bibliográfico de 78 referencias reveló que Sinaloa está representada por 17 órdenes, 52 familias, 217 géneros y 464 especies de poliquetos. Phyllodocida, Eunicida, Sabellida, Spionida, Cirratulida y Terebellida fueron los órdenes más representativos; mientras que Spionidae, Nereididae, Eunicidae, Lumbrineridae, Onuphidae y Phyllodocidae lo fueron para las familias; Eunice (Eunicidae), Scoletoma (Lumbrineridae) y Aricidea (Paraonidae) para los géneros. Sinaloa presenta uno de los números de especies de poliquetos más elevados en México; no obstante, poco más del 70% de las especies son cuestionables para la región. Todos los poliquetos exóticos registrados en el Pacífico mexicano se encuentran en Sinaloa. Un mayor número de especies fueron registradas por encima de la zona del mínimo de oxígeno (ZMO) que en la capa inferior; la distribución discontinua de las especies encomún de ambas capas es cuestionable, ninguna especie ha sido registrada en la ZMO de Sinaloa. La ZMO representa una barrera fisiológica para la migración vertical en la columna de agua.Palabras clave: Distribución batimétrica, especies cosmopolitas, especies exóticas, localidad tipo, poliquetofauna, Sinaloa, zonadel mínimo de oxígeno.ABSTRACT: Sinaloa is a Mexican state located in the  Southeastern Gulf of California, represented by a wide macroinvertebrates biodiversity, including polychaetes. This group is highly diverse in the state, nevertheless, the information on the species’ records are scattered in numerous sources. There is a high presence of supposed cosmopolitan polychaetes in the Eastern Tropical Pacific (ETP), therefore it is expected that numerous species are questionable to Sinaloa. The purpose of this study was to compile the name of all polychaete species currently registered in Sinaloa, including the bathymetric distribution and an assessment of their biogeographic distribution in the zoogeographic region ETP. We conducted a broad literature search to compile records of polychaete species dated until 2014. The bathymetric distribution in the state and the type locality of the species is given. The literature review of 78 references revealed that 17 orders, 52 families, 217 genera and 464 species of polychaetes are in Sinaloa. Phyllodocida, Eunicida, Sabellida, Spionida, Cirratulida and Terebellida were the most representative orders, while Spionidae, Nereididae, Eunicidae, Lumbrineridae, Onuphidae and Phyllodocidae were to the families; Eunice (Eunicidae), Scoletoma (Lumbrineridae) and Aricidea (Paraoindiae) were to the genera. Sinaloa has one of the highest numbers of polychaete species in Mexico; however, more than 70% are questionable species in the region. All the exotic polychaete species recorded in the Mexican Pacific are in Sinaloa. More polychaete species were recorded in the upper layer over the oxygen minimum zone (OMZ) than in the lower. The discontinuous distribution of species in common of both layers is questionable; any species has been recorded in the OMZ of Sinaloa. OMZ represents a physiological barrier to upward migration of species in the water column.Key words: Bathymetric distribution, cosmopolitan species, alien species, type locality, polychaete fauna, Sinaloa, oxygen minimum zone

A closer look at the taxonomic and genetic diversity of endemic South African Marphysa Quatrefages, 1865

The current study investigates the final unresolved cosmopolitan species of Marphysa in South Africa, Marphysa corallina, collected from KwaZulu Natal, Eastern and Western Cape provinces, together with another species collected from northern KwaZulu Natal. Morphological and genetic data prove that M. corallina, originally described from Hawaii, does not occur in South Africa. The curvature of the inner base on maxilla I, the elevated inner base of maxilla II, and the ventral cirrus as a transverse welt with a rounded tip allow us to identify it as a new species of Treadwellphysa, T. izinqa sp. nov. (common name: brown wonderworm). Characteristic traits include the basal reddish and distal golden colour of the subacicular hook, the ear-shaped postchaetal lobe, and tridentate falcigers which is reported for the first time for the genus. This species is harvested as bait on the south coast of SA, although less frequently than the more common blood wonderworm, Marphysa haemasona Quatrefages, 1866, and can be distinguished by its more uniform brown colouration and white-tipped antennae. A second species, Marphysa mzingazia sp. nov., is characterized by red eyes, six branchial filaments extending to the posterior end, the golden aciculae in posterior chaetigers, weakly bidentate yellow/brown subacicular hooks, and the presence of similar sized spinigers along the body. A molecular analysis based on cytochrome oxidase I fragments confirm both taxa as different species. A key for all South African species of Marphysa is included