Alternative antibody for the detection of CA125 antigen: a European multicenter study for the evaluation of the analytical and clinical performance of the Access (R) OV Monitor assay on the UniCel (R) Dxl 800 Immunoassay System

Background: Cancer antigen CA125 is known as a valuable marker for the management of ovarian cancer. Methods: The analytical and clinical performance of the Access OV Monitor Immunoassay System (Beckman Coulter) was evaluated at five different European sites and compared with a reference system, defined as CA125 on the Elecsys System (Roche Diagnostics). Results: Total imprecision (%CV) of the OV Monitor ranged between 3.1% and 8.8%, and inter-laboratory reproducibility between 4.7% and 5.0%. Linearity upon dilution showed a mean recovery of 100% (SD+8.1%). Endogenous interferents had no influence on OV Monitor levels (mean recoveries: hemoglobin 107%, bilirubin 103%, triglycericles 103%). There was no high-dose hook effect up to 27,193 kU/L. Clinical performance investigated in sera from 1811 individuals showed a good correlation between the Access OV Monitor and Elecsys CA125 (R = 0.982, slope = 0.921, intercept = + 1.951). OV Monitor serum levels were low in healthy individuals (n = 267, median = 9.7 kU/L, 95th percentile = 30.8 kU/L), higher in individuals with various benign diseases (n = 549, medians = 10.9-16.4 kU/L, 95th percentiles = 44.2-355 kU/L) and even higher in individuals suffering from various cancers (n = 995, medians= 12.4-445 kU/L; 95th percentiles = 53.4-4664 kU/L). Optimal diagnostic accuracy for cancer detection against the relevant benign control group by the OV Monitor was found for ovarian cancer {[}area under the curve (AUC) 0.898]. Results for the reference CA125 assay were comparable (AUC 0.899). Conclusions: The Access OV Monitor provides very good methodological characteristics and demonstrates an excellent analytical and clinical correlation with Elecsys CA125. The best diagnostic accuracy for the OV Monitor was found in ovarian cancer. Our results also suggest a clinical value of the OV Monitor in other cancers

Power Switching in Hybrid Coherent Couplers

We report on a theoretical and numerical investigation of the switching of power in new hybrid models of nonlinear coherent couplers consisting of optical slab waveguides with various orders of nonlinearity. The first model consists of two guides with second-order instead of the usual third-order susceptibilities as typified by the Jensen coupler. This second-order system is shown to have a power self-trapping transition at a critical power greater than the third-order susceptibility coupler. Next, we consider a mixed coupler composed of a second-order guide coupled to a third-order guide and show that, although it does not display a rigorous self-trapping transition, for a particular choice of parameters it does show a fairly abrupt trapping of power at a lower power than in the third-order coupler. By coupling this mixed nonlinear pair to a third, purely linear guide, the power trapping can be brought to even lower levels and in this way a satisfactory switching profile can be achieved at less than one sixth the input power needed in the Jensen coupler.Comment: Latex source,17 pages, 5 figure

Vevacious: A Tool For Finding The Global Minima Of One-Loop Effective Potentials With Many Scalars

Several extensions of the Standard Model of particle physics contain additional scalars implying a more complex scalar potential compared to that of the Standard Model. In general these potentials allow for charge and/or color breaking minima besides the desired one with correctly broken SU(2)_L times U(1)_Y . Even if one assumes that a metastable local minimum is realized, one has to ensure that its lifetime exceeds that of our universe. We introduce a new program called Vevacious which takes a generic expression for a one-loop effective potential energy function and finds all the tree-level extrema, which are then used as the starting points for gradient-based minimization of the one-loop effective potential. The tunneling time from a given input vacuum to the deepest minimum, if different from the input vacuum, can be calculated. The parameter points are given as files in the SLHA format (though is not restricted to supersymmetric models), and new model files can be easily generated automatically by the Mathematica package SARAH. This code uses HOM4PS2 to find all the minima of the tree-level potential, PyMinuit to follow gradients to the minima of the one-loop potential, and CosmoTransitions to calculate tunneling times.Comment: 44 pages, 1 figure, manual for publicly available software, v2 corresponds to version accepted for publication in EPJC [clearer explanation of scale dependence and region of validity, explicit mention that SLHA files should have blocks matching those expected by model files, updated references

The role of slip transfer at grain boundaries in the propagation of microstructurally short fatigue cracks in Ni-based superalloys

Crack initiation and propagation under high-cycle fatigue conditions have been investigated for a polycrystalline Ni-based superalloy by in-situ synchrotron assisted diffraction and phase contrast tomography. The cracks nucleated along the longest coherent twin boundaries pre-existing on the specimen surface, that were well oriented for slip and that presented a large elastic incompatibility across them. Moreover, the propagation of microstructurally short cracks was found to be determined by the easy slip transfer paths across the pre-existing grain boundaries. This information can only be obtained by characterization techniques like the ones presented here that provide the full set of 3D microstructural information

Binary Biometrics: An Analytic Framework to Estimate the Bit Error Probability under Gaussian Assumption

In recent years the protection of biometric data has gained increased interest from the scientific community. Methods such as the helper data system, fuzzy extractors, fuzzy vault and cancellable biometrics have been proposed for protecting biometric data. Most of these methods use cryptographic primitives and require a binary representation from the real-valued biometric data. Hence, the similarity of biometric samples is measured in terms of the Hamming distance between the binary vector obtained at the enrolment and verification phase. The number of errors depends on the expected error probability Pe of each bit between two biometric samples of the same subject. In this paper we introduce a framework for analytically estimating Pe under the assumption that the within-and between-class distribution can be modeled by a Gaussian distribution. We present the analytic expression of Pe as a function of the number of samples used at the enrolment (Ne) and verification (Nv) phases. The analytic expressions are validated using the FRGC v2 and FVC2000 biometric databases

Constraining the Natural MSSM through tunneling to color-breaking vacua at zero and non-zero temperature

We re-evaluate the constraints on the parameter space of the minimal supersymmetric standard model from tunneling to charge- and/or color-breaking minima, taking into account thermal corrections. We pay particular attention to the region known as the Natural MSSM, where the masses of the scalar partners of the top quarks are within an order of magnitude or so of the electroweak scale. These constraints arise from the interaction between these scalar tops and the Higgs fields, which allows the possibility of parameter points having deep charge- and color-breaking true vacua. In addition to requiring that our electro-weak-symmetry-breaking, yet QCD- and electromagnetism-preserving vacuum has a sufficiently long lifetime at zero temperature, also demanding stability against thermal tunneling further restricts the allowed parameter space.Comment: 7 pages, 2 figures, software available from http://vevacious.hepforge.org/ - version 2 matches that accepted for publication in Phys. Lett.