Education in IT Security: A Case Study in Banking Industry

The banking industry has been changing incessantlyand facing new combination of risks. Data protection andcorporate security is now one of the major issues in bankingindustry. As the rapid changing on technologies from time totime, the industry should be aware on new technologies in orderto protect information assets and prevent fraud activities. Thispaper begins with literature study of information security issuesand followed by focused-group interviews with five participantswithin the industry and survey analysis of “The global state ofInformation Security survey 2013” which published byPriceWaterhouseCoopers (PWC). Trends and questions werediscussed as well as possible solution. The study suggests that ITsecurity education should be made to different level of staffs suchas executives, professional and general staffs. Besides, thebanking industry should increase company-wide securityawareness and the importance of corporate security which keepthe information and physical assets secure and in a proper way

The Galaxy platform for accessible, reproducible, and collaborative data analyses: 2024 update

YesGalaxy (https://galaxyproject.org) is deployed globally, predominantly through free-to-use services, supporting user-driven research that broadens in scope each year. Users are attracted to public Galaxy services by platform stability, tool and reference dataset diversity, training, support and integration, which enables complex, reproducible, shareable data analysis. Applying the principles of user experience design (UXD), has driven improvements in accessibility, tool discoverability through Galaxy Labs/subdomains, and a redesigned Galaxy ToolShed. Galaxy tool capabilities are progressing in two strategic directions: integrating general purpose graphical processing units (GPGPU) access for cutting-edge methods, and licensed tool support. Engagement with global research consortia is being increased by developing more workflows in Galaxy and by resourcing the public Galaxy services to run them. The Galaxy Training Network (GTN) portfolio has grown in both size, and accessibility, through learning paths and direct integration with Galaxy tools that feature in training courses. Code development continues in line with the Galaxy Project roadmap, with improvements to job scheduling and the user interface. Environmental impact assessment is also helping engage users and developers, reminding them of their role in sustainability, by displaying estimated CO2 emissions generated by each Galaxy job.NIH [U41 HG006620, U24 HG010263, U24 CA231877, U01 CA253481]; US National Science Foundation [1661497, 1758800, 2216612]; computational resources are provided by the Advanced Cyberinfrastructure Coordination Ecosystem (ACCESS-CI), Texas Advanced Computing Center, and the JetStream2 scientific cloud. Funding for open access charge: NIH. ELIXIR IS and Travel grants; EU Horizon Europe [HORIZON-INFRA-2021-EOSC-01-04, 101057388]; EU Horizon Europe under the Biodiversity, Circular Economy and Environment program (REA.B.3, BGE 101059492); German Federal Ministry of Education and Research, BMBF [031 A538A de.NBI-RBC]; Ministry of Science, Research and the Arts Baden-Württemberg (MWK) within the framework of LIBIS/de.NBI Freiburg. Galaxy Australia is supported by the Australian BioCommons which is funded through Australian Government NCRIS investments from Bioplatforms Australia and the Australian Research Data Commons, as well as investment from the Queensland Government RICF program

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Characterization of libid-based DNA delivery systems

This thesis is focused on characterizing two lipid-based gene delivery systems: plasmid DNA-cationic lipid "complexes" and stabilized plasmid-lipid particles (SPLP). Complexes have utility for gene transfer in vitro whereas SPLP are designed for systemic gene therapy applications in vivo. In Chapter 2, the structural and fusogenic properties of complexes formed by mixing pCMV5 plasmid DNA with large unilamellar vesicles (LUVs) composed of the cationic lipid N-[2,3-(dioleyloxy)propyl]- N,N,N-trimethylammonium chloride (DOTMA) and l,2-dioleoyl-3-phosphatidylethanolamine (DOPE) or l,2-dioleoyl-3- phosphatidylcholine (DOPC) are examined and correlated with transfection potency. It is shown, employing lipid mixing fusion assays, that pCMV5 plasmid strongly promotes fusion between these cationic vesicles. Freeze fracture electron microscopy studies demonstrate association of cationic vesicles to form clusters at low pCMV5 content, whereas macroscopic fused aggregates can be observed at higher plasmid levels. ³¹P NMR studies on the fused DNA-DOTMA/DOPE (1:1) complexes obtained at high plasmid levels (charge ratio 1.0) reveal narrow "isotropic" ³¹P NMR resonances, whereas the corresponding DOPC containing systems exhibit much broader "bilayer" ³¹P NMR spectra. In agreement with previous studies, the transfection potency of the DOPE containing systems is dramatically higher than for the DOPC containing complexes, indicating a correlation between transfection potential and the motional properties of endogenous lipids. It is suggested that the ³¹P NMR characteristics of complexes lipid structures, which may play a direct role in the fusion or membrane destabilization events vital to transfection. In Chapter 3, the influence of variations in the lipid component of SPLP on plasmid trapping and transfection potency in vitro are characterized. It is shown that SPLP formed with different monovalent cationic lipids exhibit similar plasmid entrapment properties but different transfection potencies. The poly(ethylene glycol) (PEG) density in SPLP can substantially influence both SPLP formation and transfection. By decreasing the length of the fatty acyl component of the PEG-ceramide anchor from 20 to 14 to 8 carbons, or by using smaller PEG chains (PEG₇₅₀, PEG₂₀₀₀ as compared with PEG₅₀₀₀), higher transfection levels were observed, consistent with a requirement for PEG removal in order for efficient transfection to occur. Further, it is shown that the primary factor limiting the transfection potency of SPLP is association and uptake into target cells. The final set of experiments in Chapter 4 was focused on characterizing the influence of the plasmid component in the formation of SPLP. It is shown that encapsulation efficiencies remain at 50 % or higher for (initial) plasmid-to-lipid ratios of up to 70 μg/μmol, allowing the proportion of lipid in empty vesicles following detergent dialysis to be significantly reduced compared to previous protocols. In addition, it is shown that the encapsulation efficiency is sensitive to the conformation of the plasmid employed, where higher encapsulation is observed for linearized plasmid as compared to plasmid in supercoiled or relaxed circular conformations. However, lower transfection potency for linearized plasmid was observed in SPLP and plasmid DNA-cationic lipid complexes.Medicine, Faculty ofBiochemistry and Molecular Biology, Department ofGraduat

Polo-like kinase 1, a new therapeutic target in hepatocellular carcinoma

10.3748/wjg.v18.i27.3527World Journal of Gastroenterology18273527-3536WJGA

Design of monolithic RF power amplifier using bulk BiCMOS process

A low-voltage monolithic 900MHz power amplifier has been fabricated in a commercial 0.8μm bulk BiCMOS process with an integrated output tuned circuit. The tuned circuit is implemented by a monolithic inductor of 2.6nH with 54μm metal width. The output power of the amplifier is 14dBm

Delrin as an occluder material

ASAIO Transactions363M417-M421ASAT

A high-output-current and low-power-loss thin-film transistor liquid-crystal display (TFT-LCD) driver for portable devices

The application range of traditional thin-film transistor (TFT) liquid-crystal display (LCD) drivers powered by switched-capacitor DC-DC converters (charge pumps) used in portable devices are, to a certain extent, restricted because of their inability to support applications that require high driving current for generating high resolution graphics or powering larger LCD panels. This paper reviews the limitations of charge pumps when used on TFT-LCD drivers fabricated using the chip-on-glass (COG) packaging technology. A high-output-current low-power-loss boost-type DC-DC converter is proposed to replace traditional charge pumps while retaining the existing COG packaging technology in order to reduce production cost. A prototype of the proposed converter is designed with a standard 0.13 μm HV CMOS process. Compared with traditional designs, the proposed converter demonstrates that it is capable of delivering a higher driving current at a much smaller power loss.Department of Electronic and Information Engineerin

Molecular and functional characterization of drug-metabolizing enzymes and transporter expression in the novel spontaneously immortalized human hepatocyte line HC-04

10.1016/j.tiv.2007.05.003Toxicology in Vitro2181390-140