Two sides of the same coin: The roles of KLF6 in physiology and pathophysiology

The Krüppel-like factors (KLFs) family of proteins control several key biological processes that include proliferation, differentiation, metabolism, apoptosis and inflammation. Dysregulation of KLF functions have been shown to disrupt cellular homeostasis and contribute to disease development. KLF6 is a relevant example; a range of functional and expression assays suggested that the dysregulation of KLF6 contributes to the onset of cancer, inflammation-associated diseases as well as cardiovascular diseases. KLF6 expression is either suppressed or elevated depending on the disease, and this is largely due to alternative splicing events producing KLF6 isoforms with specialised functions. Hence, the aim of this review is to discuss the known aspects of KLF6 biology that covers the gene and protein architecture, gene regulation, post-translational modifications and functions of KLF6 in health and diseases. We put special emphasis on the equivocal roles of its full-length and spliced variants. We also deliberate on the therapeutic strategies of KLF6 and its associated signalling pathways. Finally, we provide compelling basic and clinical questions to enhance the knowledge and research on elucidating the roles of KLF6 in physiological and pathophysiological processes. © 2020 by the authors. Licensee MDPI, Basel, Switzerland

Opportunities and Challenges for Establishing a Resource Nexus Community of Science and Practice

The American Chemical Society’s Division of Environmental Chemistry symposium Toward Creating a Water-Energy-Food (WEF) Nexus Community of Practice, brought together 25 cross-disciplinary speakers in five thematic areas: 1) state of the art models and approaches, 2) WEF Nexus initiatives and case studies, 3) WEF governance and stakeholder engagement, 4) chemical processes and WEF Nexus, 5) WEF education, community, and practice. Discussions included diverse perspectives from different areas of expertise and provided key take-home messages toward building a WEF community of practice. This paper summarizes those messages, drawing conclusions regarding the anticipated challenges and opportunities moving toward establishing a resource-nexus community of science and practice that includes the chemical societies. We define the community of science and practice as a bottom-up approach of formal and non-formal scientists, policy makers, practitioners, technology providers, and civil society members concerned with any aspect of water, energy, food, ecosystem resources allocation, management, governance, and financing. The roles of chemistry and chemical processes in understanding the interlinkages of nexus systems must not be overlooked. Chemistry plays an important role in the circularity of the food and agriculture system, and in providing cleaner energy, cleaner water, and more sustainable food production. The question is how to better engage the chemical society in the WEF nexus moving forward? The paper proposes the resource of health, highlighting major challenges and opportunities in the Water-Energy-Food-Health-Ecosystems (WEFH) Nexus, and highlights future steps for fostering dialogue among this broad, multidisciplinary, multi-stakeholder community toward establishing an inclusive community of science and practice. Copyright © 2022 Mohtar, Sharma, Daher, Laspidou, Kim, Pistikopoulos, Nuwayhid, Lawford, Rhouma and Najm

Towards an end-to-end analysis and prediction system for weather, climate, and Marine applications in the Red Sea

The Red Sea, home to the second-longest coral reef system in the world, is a vital resource for the Kingdom of Saudi Arabia. The Red Sea provides 90% of the Kingdom’s potable water by desalinization, supporting tourism, shipping, aquaculture, and fishing industries, which together contribute about 10%–20% of the country’s GDP. All these activities, and those elsewhere in the Red Sea region, critically depend on oceanic and atmospheric conditions. At a time of mega-development projects along the Red Sea coast, and global warming, authorities are working on optimizing the harnessing of environmental resources, including renewable energy and rainwater harvesting. All these require high-resolution weather and climate information. Toward this end, we have undertaken a multipronged research and development activity in which we are developing an integrated data-driven regional coupled modeling system. The telescopically nested components include 5-km- to 600-m-resolution atmospheric models to address weather and climate challenges, 4-km- to 50-m-resolution ocean models with regional and coastal configurations to simulate and predict the general and mesoscale circulation, 4-km- to 100-m-resolution ecosystem models to simulate the biogeochemistry, and 1-km- to 50-m-resolution wave models. In addition, a complementary probabilistic transport modeling system predicts dispersion of contaminant plumes, oil spill, and marine ecosystem connectivity. Advanced ensemble data assimilation capabilities have also been implemented for accurate forecasting. Resulting achievements include significant advancement in our understanding of the regional circulation and its connection to the global climate, development, and validation of long-term Red Sea regional atmospheric–oceanic–wave reanalyses and forecasting capacities. These products are being extensively used by academia, government, and industry in various weather and marine studies and operations, environmental policies, renewable energy applications, impact assessment, flood forecasting, and more. © 2021 American Meteorological Societ