Describing Polymers Synthesized from Reducing Sugars and Ammonia Employing FTIR Spectroscopy

          يمكن تشخيص الميلانويد باستخدام تقنية مطيافية الأشعة تحت الحمراء (FTIR) . أن UV/Vis هي أداة فعالة للتحليل النوعي والكمي للمكونات الكيميائية في بوليمرات الميلانودين. تتطابق الميزات الهيكلية والاهتزازية للميلانويدات المُصنَّعة من D-Glucose و D-Fructose ، وفقًا لأطياف FTIR ، مع الاختلاف الوحيد في شدة القمم. باستخدام أطياف FTIR ، ينقسم الهيكل التركيبي للميلانودين إلى سبع مناطق رئيسية. تم تأكيد وجود مجموعات C = C و C = N و C = O في جميع الميلانويدات المكونة من الفركتوز والجلوكوز مع الأمونيا من خلال المناطق التي تتراوح من 1600 إلى 1690 سم -1 ، ويتضح النطاق إلى حد كبير على أنه نطاق واسع. يحتوي كل من الميلانويدات على كربوكسيل أو كربونيل في المنطقة تقريبا 1700 سم -1. في جميع الميلانويدينات، اختفت مجموعة +NH في نطاق 3080 سم-1. ومع ذلك ، فإن كثافة اللون تعتمد على نوع السكر المستخدم في تخليق الميلانويدين. علاوة على ذلك، بالمقارنة مع ميلانويدين المخلق من الأمونيا و الكلوكوز Glc-ammoina ، التي تحتوي على نسبة أعلى من الكربون المهجن sp3 ، فإن الميلانويدين المخلق من الأمونيا و الفركتوز Fru-ammonia لديها نسبة أعلى من الكربون المهجن sp2 على أساس تحليل الأشعة فوق البنفسجية / المرئية و FTIR وأطياف المشتق الثاني. علاوة على ذلك ، تمت محاكاة البيانات بأستخدام تحليل المكون الرئيسي (PCA). تم استخدام تحليل المكون الرئيسي (PCA) لتفسير البيانات.          Melanoidins can be diagnosed using the Fourier transform infrared (FTIR) technique. UV/Vis is an effective tool for both qualitative and quantitative analysis of chemical components in melanoidin polymers. The structural and vibrational features of melanoidin synthesized from D-glucose and D-fructose are identical, according to FTIR spectra, with the only difference being the intensity of bands.  Using FTIR spectra, the skeleton of melanoidin is divided into seven major regions. The existence of the C=C, C=N, and C=O groups in all melanoidins formed from fructose and glucose with ammonia is confirmed by the areas ranging from 1600 to 1690 cm-1, and the band is largely evident as a broad shoulder. Both melanoidins have a carboxyl or carbonyl extending around 1700 cm-1. In all melanoidins, the NH+ group has vanished in the 3080 cm-1 range. However, the color intensity depends on the type of sugar employed in melanoidin synthesis. Furthermore, in comparison to Glc-ammonia, which has a higher proportion of sp3 hybridized carbon, Fru-ammonia has a higher proportion of sp2 hybridized carbon based on UV/Vis, FTIR and second-derivative spectra. Moreover, the data were simulated using principal component analysis. Principal component analysis (PCA) was used to interpret the data

Global economic burden of unmet surgical need for appendicitis

Background There is a substantial gap in provision of adequate surgical care in many low- and middle-income countries. This study aimed to identify the economic burden of unmet surgical need for the common condition of appendicitis. Methods Data on the incidence of appendicitis from 170 countries and two different approaches were used to estimate numbers of patients who do not receive surgery: as a fixed proportion of the total unmet surgical need per country (approach 1); and based on country income status (approach 2). Indirect costs with current levels of access and local quality, and those if quality were at the standards of high-income countries, were estimated. A human capital approach was applied, focusing on the economic burden resulting from premature death and absenteeism. Results Excess mortality was 4185 per 100 000 cases of appendicitis using approach 1 and 3448 per 100 000 using approach 2. The economic burden of continuing current levels of access and local quality was US $92 492 million using approach 1 and$73 141 million using approach 2. The economic burden of not providing surgical care to the standards of high-income countries was $95 004 million using approach 1 and$75 666 million using approach 2. The largest share of these costs resulted from premature death (97.7 per cent) and lack of access (97.0 per cent) in contrast to lack of quality. Conclusion For a comparatively non-complex emergency condition such as appendicitis, increasing access to care should be prioritized. Although improving quality of care should not be neglected, increasing provision of care at current standards could reduce societal costs substantially

Global economic burden of unmet surgical need for appendicitis

Background There is a substantial gap in provision of adequate surgical care in many low- and middle-income countries. This study aimed to identify the economic burden of unmet surgical need for the common condition of appendicitis. Methods Data on the incidence of appendicitis from 170 countries and two different approaches were used to estimate numbers of patients who do not receive surgery: as a fixed proportion of the total unmet surgical need per country (approach 1); and based on country income status (approach 2). Indirect costs with current levels of access and local quality, and those if quality were at the standards of high-income countries, were estimated. A human capital approach was applied, focusing on the economic burden resulting from premature death and absenteeism. Results Excess mortality was 4185 per 100 000 cases of appendicitis using approach 1 and 3448 per 100 000 using approach 2. The economic burden of continuing current levels of access and local quality was US $92 492 million using approach 1 and$73 141 million using approach 2. The economic burden of not providing surgical care to the standards of high-income countries was $95 004 million using approach 1 and$75 666 million using approach 2. The largest share of these costs resulted from premature death (97.7 per cent) and lack of access (97.0 per cent) in contrast to lack of quality. Conclusion For a comparatively non-complex emergency condition such as appendicitis, increasing access to care should be prioritized. Although improving quality of care should not be neglected, increasing provision of care at current standards could reduce societal costs substantially