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Long-term follow-up of 22 psoriatic patients treated with ixekizumab after failure of secukinumab
Switching of biologic agents in treatment of plaque psoriasis is a common strategy. Only a few studies are available on switching between IL17A-blockers. In a retrospective study, we identified 22 psoriasis patients who, after failing secukinumab as a first IL17A-blocker received ixekizumab with an observation period of at least 24 weeks. At last observation 10/22 patients had a good response (PASI75 or PASI<3) using ixekizumab therapy. None of five patients with primary non-response to secukinumab reached a good, durable response to ixekizumab. In conclusion, ixekizumab appears to be a therapeutic option as a second IL17A-blocker in psoriasis patients who did not show a primary non-response to secukinumab
Lamb Shift of 3P and 4P states and the determination of
The fine structure interval of P states in hydrogenlike systems can be
determined theoretically with high precision, because the energy levels of P
states are only slightly influenced by the structure of the nucleus. Therefore
a measurement of the fine structure may serve as an excellent test of QED in
bound systems or alternatively as a means of determining the fine structure
constant with very high precision. In this paper an improved analytic
calculation of higher-order binding corrections to the one-loop self energy of
3P and 4P states in hydrogen-like systems with low nuclear charge number is
presented. A comparison of the analytic results to the extrapolated numerical
data for high ions serves as an independent test of the analytic
evaluation. New theoretical values for the Lamb shift of the P states and for
the fine structure splittings are given.Comment: 33 pages, LaTeX, 4 tables, 4 figure
QED self-energy contribution to highly-excited atomic states
We present numerical values for the self-energy shifts predicted by QED
(Quantum Electrodynamics) for hydrogenlike ions (nuclear charge ) with an electron in an , 4 or 5 level with high angular momentum
(). Applications include predictions of precision transition
energies and studies of the outer-shell structure of atoms and ions.Comment: 20 pages, 5 figure
Sudbury project (University of Muenster-Ontario Geological Survey): Petrology, chemistry, and origin of breccia formations
Within the Sudbury Project of the University of Muenster and the Ontario Geological Survey special emphasis was put on the breccia formations exposed at the Sudbury structure (SS) because of their crucial role for the impact hypothesis. They were mapped and sampled in selected areas of the north, east, and south ranges of the SS. The relative stratigraphic positions of these units are summarized. Selected samples were analyzed by optical microscopy, SEM, microprobe, XRF and INAA, Rb-Sr and SM-Nd-isotope geochemistry, and carbon isotope analysis. The results of petrographic and chemical analysis for those stratigraphic units that were considered the main structural elements of a large impact basin are summarized
The X-ray Size-Temperature Relation for Intermediate Redshift Galaxy Clusters
We present the first measurements of the X-ray size-temperature (ST) relation
in intermediate redshift (z~0.30) galaxy clusters. We interpret the local ST
relation (z~0.06) in terms of underlying scaling relations in the cluster dark
matter properties, and then we use standard models for the redshift evolution
of those dark matter properties to show that the ST relation does not evolve
with redshift. We then use ROSAT HRI observations of 11 clusters to examine the
intermediate redshift ST relation; for currently favored cosmological
parameters, the intermediate redshift ST relation is consistent with that of
local clusters. Finally, we use the ST relation and our evolution model to
measure angular diameter distances; with these 11 distances we evaluate
constraints on Omega_M and Omega_L which are consistent with those derived from
studies of Type Ia supernovae. The data rule out a model with Omega_M=1 and
Omega_L=0 with 2.5 sigma confidence. When limited to models where
Omega_M+Omega_L=1, these data are inconsistent with Omega_M=1 with 3 sigma
confidence.Comment: ApJ: submitted April 7, accepted June 28, to appear Dec 1 (vol 544
Lamm, Valluri, Jentschura and Weniger comment on "A Convergent Series for the QED Effective Action" by Cho and Pak [Phys. Rev. Lett. vol. 86, pp. 1947-1950 (2001)]
Complete results were obtained by us in [Can. J. Phys. 71, 389 (1993)] for
convergent series representations of both the real and the imaginary part of
the QED effective action; these derivations were based on correct intermediate
steps. In this comment, we argue that the physical significance of the
"logarithmic correction term" found by Cho and Pak in [Phys. Rev. Lett. 86,
1947 (2001)] in comparison to the usual expression for the QED effective action
remains to be demonstrated. Further information on related subjects can be
found in Appendix A of hep-ph/0308223 and in hep-th/0210240.Comment: 1 page, RevTeX; only "meta-data" update
The s-process branching at 185W
The neutron capture cross section of the unstable nucleus 185W has been
derived from experimental photoactivation data of the inverse reaction
186W(gamma,n)185W. The new result of sigma = (687 +- 110) mbarn confirms the
theoretically predicted neutron capture cross section of 185W of sigma = 700
mbarn at kT = 30 keV. A neutron density in the classical s-process of n_n =
(3.8 +0.9 -0.8} * 1e8 cm-3 is derived from the new data for the 185W branching.
In a stellar s-process model one finds a significant overproduction of the
residual s-only nucleus 186Os.Comment: ApJ, in pres
Improvement of Shelf Life for Space Food Through a Hurdle Approach
The processed and prepackaged spaceflight food system is a critical human support system for manned space flights. As missions extend longer and farther from Earth over the next 20 years, strategies to stabilize the nutritional and sensory quality of food must be identified. For a mission to Mars, the space foods themselves must maintain quality for up to 5 years to align with cargo prepositioning scenarios. Optimizing the food system to achieve a 5-year shelf life mitigates the risk of an inadequate food system during extended missions. Because previous attempts to determine a singular pathway to a 5-year shelf life for food were unsuccessful, this investigation combines several approaches, based on science, technological advancement, and past empirical evidence, that will define the prepackaged food system for long duration missions. This study supports the Advanced Food Technology strategic planning process by identifying food processing, packaging, and storage technologies that will be required for exploration missions and the extent that they must be implemented to achieve a 5-year shelf life for the entire food system
Sudbury project (University of Muenster-Ontario Geological Survey): Summary of results - an updated impact model
In 1984 the Ontario Geological Survey initiated a research project on the Sudbury structure (SS) in cooperation with the University of Muenster. The project included field mapping (1984-1989) and petrographic, chemical, and isotope analyses of the major stratigraphic units of the SS. Four diploma theses and four doctoral theses were performed during the project (1984-1992). Specific results of the various investigations are reported. Selected areas of the SS were mapped and sampled: Footwall rocks; Footwall breccia and parts of the sublayer and lower section of the Sudbury Igneous Complex (SIC); Onaping Formation and the upper section of the SIC; and Sudbury breccia and adjacent Footwall rocks along extended profiles up to 55 km from the SIC. All these stratigraphic units of the SS were studied in substantial detail by previous workers. The most important characteristic of the previous research is that it was based either on a volcanic model or on a mixed volcanic-impact model for the origin of the SS. The present project was clearly directed toward a test of the impact origin of the SS without invoking an endogenic component. In general, our results confirm the most widely accepted stratigraphic division of the SS. However, our interpretation of some of the major stratigraphic units is different from most views expressed. The stratigraphy of the SS and its new interpretation is given as a basis for discussion
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