52 research outputs found
Anti-oxidant, anti-apoptotic, and protective effects of myricitrin and its solid lipid nanoparticle on streptozotocin-nicotinamide induced diabetic nephropathy in type 2 diabetic male mice
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TEMPOâModified Polymethacrylates as Mediators in Electrosynthesis â Redox Behavior and Electrocatalytic Activity toward Alcohol Substrates
Homogeneous catalysts (âmediatorsâ) are useful for tuning selectivity in organic electrosynthesis. However, they can have a negative impact on the overall mass and energy balance if used only once or recycled inefficiently. In a previous work, we introduced the polymediator concept, in which soluble redox-active polymers catalyze the electrochemical reaction, allowing for recovery by dialysis or pressure-driven membrane filtration. Using anodic alcohol oxidation as a test case, it was shown that TEMPO-modified polymethacrylates (TPMA) can serve as efficient and reusable mediators. In the present study, the properties of a TPMA sample with well-defined molecular weight distribution were studied using cyclic voltammetry and compared to low-molecular TEMPO species. The non-catalytic profiles of TPMA are shaped by diffusive and adsorptive processes, whereby the latter only become pronounced at low mediator concentrations and high scan rates. Electrocatalytic studies suggest that under the applied conditions, TPMA-catalyzed alcohol oxidation is a predominantly homogeneous process. The homogeneous kinetics are determined rather by the mediator potential than by steric influences of the polymer backbone. © 2021 The Authors. ChemElectroChem published by Wiley-VCH Gmb
Comparison of the neuroprotective effects of aspirin, atorvastatin, captopril and metformin in diabetes mellitus
Objective: The aim of this study was to investigate the effect of combined intake of a high dose of aspirin, atorvastatin, captopril and metformin on oxidative stress in the brain cortex and hippocampus of streptozotocin (STZ)-induced diabetic rats. Material and methods: Rats were randomly divided into the following 11 groups: control and diabetic (D), as well as 9 groups that were treated with metformin (M, 300 mg/kg) or aspirin (ASA, 120 mg/kg) alone or in different combinations with captopril (C, 50 mg/kg) and/or atorvastatin (AT, 40 mg/kg) as follows: (D + M), (D + ASA), (D + M + ASA), (D + M + C), (D + M + AT), (D + M + C + ASA), (D + M + C + AT), (D + M + AT + ASA) and (D + M + C + AT + ASA). The rats in treatment groups received drugs by gavage daily for six weeks. Serum lipid profile and levels of oxidative markers in the brain cortex and hippocampus tissues were evaluated. Results: The levels of malondialdehyde in the brain cortex and hippocampus in all the treated groups decreased significantly (p < 0.05). There was a significant increase in the total thiol concentration as well as catalase activity in treated rats in (M + AT), (M + C + ASA), (M + C + AT), (M + AT + ASA) and (M + C + AT + ASA) groups in cortex and hippocampus in comparison with the diabetic rats (p < 0.05). Also, the superoxide dismutase activity in all treated rats with medications was significantly increased compared to the diabetic rats (p < 0.05â0.01). Conclusion: Our findings showed that the combined use of high-dose aspirin, metformin, captopril and atorvastatin potentiated their antioxidant effects on the brain, and hence could potentially improve cognitive function with their neuroprotective effects on hippocampus
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TEMPO-Modified Polymethacrylates as Mediators in Electrosynthesis: Influence of the Molecular Weight on Redox Properties and Electrocatalytic Activity
Homogeneous catalysts (âmediatorsâ) are frequently employed in organic electrosynthesis to control selectivity. Despite their advantages, they can have a negative influence on the overall energy and mass balance if used only once or recycled inefficiently. Polymediators are soluble redox-active polymers applicable as electrocatalysts, enabling recovery by dialysis or membrane filtration. Using anodic alcohol oxidation as an example, we have demonstrated that TEMPO-modified polymethacrylates (TPMA) can act as efficient and recyclable catalysts. In the present work, the influence of the molecular size on the redox properties and the catalytic activity was carefully elaborated using a series of TPMAs with well-defined molecular weight distributions. Cyclic voltammetry studies show that the polymer chain length has a pronounced impact on the key-properties. Together with preparative-scale electrolysis experiments, an optimum size range was identified for polymediator-guided sustainable reaction control
Effect of the cholinergic system of the lateral periaqueductal gray (lPAG) on blood pressure and heart rate in normal and hydralazine hypotensive rats
Objective(s): Due to the presence of the cholinergic system in the lateral periaqueductal gray (lPAG) column, the cardiovascular effects of Acetylcholine (ACH) and its receptors in normotensive and hydralazine (HYD) hypotensive rats in this area were evaluated.Materials and Methods: After anesthesia, the femoral artery was cannulated and systolic blood pressure (SBP), mean arterial pressure (MAP), heart rate (HR), and also electrocardiogram for evaluation of low frequency (LF) and high frequency (HF) bands, important components of heart rate variability (HRV), were recorded. ACH, atropine (Atr, a muscarinic antagonist), and hexamethonium (Hex, an antagonist nicotinic) alone and together microinjected into lPAG, changes (Î) of cardiovascular responses and normalized (n) LF, HF, and LF/HF ratio were analyzed.Results: In normotensive rats, ACH decreased SBP and MAP, and enhanced HR while Atr and Hex did had no effects. In co-injection of Atr and Hex with ACH, only ACH+Atr significantly attenuated parameters. In HYD hypotension, ACH had no affect but Atr and Hex significantly improved the hypotensive effect. Co-injection of Atr and Hex with ACH decreased the hypotensive effect but the effect of Atr+ACH was higher. In normotensive rats, ACH decreased nLF, nHF, and nLF/nHF ratio. These parameters in the Atr +ACH group were significantly higher than in ACH group. In HYD hypotension nLF and nLF/nHF ratio increased which was attenuated by ACH. Also, Atr+ACH decreased nLF and nLF/nHF ratio and increased nHF.Conclusion: The cholinergic system of lPAG mainly via muscarinic receptors has an inhibitory effect on the cardiovascular system. Based on HRV assessment, peripheral cardiovascular effects are mostly mediated by the parasympathetic system
Electrochemistry and Reactivity of Chelationâstabilized Hypervalent Bromine(III) Compounds
Hypervalent bromine(III) reagents possess a higher electrophilicity and a stronger oxidizing power compared to their iodine(III) counterparts. Despite the superior reactivity, bromine(III) reagents have a reputation of hardâtoâcontrol and difficultâtoâsynthesize compounds. This is partly due to their low stability, and partly because their synthesis typically relies on the use of the toxic and highly reactive BrF3 as a precursor. Recently, we proposed chelationâstabilized hypervalent bromine(III) compounds as a possible solution to both problems. First, they can be conveniently prepared by electroâoxidation of the corresponding bromoarenes. Second, the chelation endows bromine(III) species with increased stability while retaining sufficient reactivity, comparable to that of iodine(III) counterparts. Finally, their intrinsic reactivity can be unlocked in the presence of acids. Herein, an inâdepth mechanistic study of both the electrochemical generation and the reactivity of the bromine(III) compounds is disclosed, with implications for known applications and future developments in the field.Deutsche Forschungsgemeinschaft
http://dx.doi.org/10.13039/501100001659European Regional Development Fund
http://dx.doi.org/10.13039/501100008530HORIZON EUROPE European Research Council
http://dx.doi.org/10.13039/100019180Estonian Research Competency Council
http://dx.doi.org/10.13039/501100005189Peer Reviewe
Anti-inflammatory, immunomodulatory and anti-oxidant effects of Ocimum basilicum L. and its main constituents: A review
Ocimum basilicum L. (O. basilicum) is an ornamental and therapeutic plant with various pharmacological effects and medical applications. In this article, detailed information on the anti-oxidant, immunomodulatory, and anti-inïŹammatory properties of O. basilicum and its main constituents was provided. The literature survey of the different databases until the end of November 2021 was explored on the immunomodulatory, anti-inïŹammatory and anti-oxidant effects of the herb and its constituents. The plant and its constituents showed diverse pharmacological effects including immunomodulatory, anti-inflammatory and anti-oxidant properties by improving of the inflammatory mediators including interleukin (IL)-10, IL-4, tumor necrosis factor-alpha (TNF-α), interferon gamma (IFN-Îł), nitric oxide (NO), serum levels of IFN-Îł, IL10 and IL-4, IgG, IgM and phospholipase A2 (PLA2), immunoglobulin E (IgE), total protein (TP), oxidant and anti-oxidant markers. O. basilicum and its main constituents therefore, could be effective on the treatment of diseases associated with inflammation, immune dysregulation and oxidative stress. The present review article provides readers with organized information about the anti-oxidant, immunomodulatory, and anti-inïŹammatory properties of O. basilicum
Effects of Zataria multiflora Extract and Carvacrol on Doxorubicin-Induced Oxidative Stress in Rat Brain
Background: Due to the antioxidant effects of Zataria multiflora (ZM) and Carvacrol (CAR) in various problems and the prominent role of the ROS in neurotoxicity induced by Doxorubicin (DOX), this study was designed to investigate the effects of ZM hydroalcoholic extract and CAR on DOX-induced oxidative stress in rat brain. Methods: 24 male rats were randomly divided into four groups including: 1)Control ,2)Doxorubicin (DOX) that received DOX via a tail vein on the first day of the study, 3,4) ZM+DOX and CAR+DOX which received ZM and CAR by gavage for 28 consecutive days. Brain tissue removed for redox markers evaluation. Results: MDA level in the DOX group was significantly increased compared to control group while in treated groups did not show any significant changes in comparison with the DOX group. Also, Thiol content in DOX group showed significant reduction compared to control group. Thiol contents in treated groups showed no significant difference compared to DOX group. Catalase (CAT) activity, an antioxidant enzyme, in the DOX group were significantly decreased compared to control group and increased in treated rats in comparison with the DOX group. Activity of Superoxide dismutase (SOD), an antioxidant enzyme, in the DOX group was significantly reduced compared to control group and increased in treated rats in comparison with the DOX group. Conclusion: The present study showed that ZM hydroalcoholic extract and CAR could inhibit DOX induced oxidative stress of the brain mainly with effect on the enzymatic antioxidant defense system
Protective effects of long-term administration of Ziziphus jujuba fruit extract on cardiovascular responses in L-NAME hypertensive rats
Objective: Ziziphus jujuba stimulates the release of nitric oxide (NO). Because NO is involved in cardiovascular regulations, in this study the effects of hydroalcoholic extract of Z. jujuba on cardiovascular responses in acute NG-nitro-L-arginine methyl ester (L-NAME) hypertensive rats were evaluated. Materials and Methods: Rats were divided into 6 group (n=6): 1) saline, 2) L-NAME received (10mg/kg) intravenously, 3) sodium nitroprusside (SNP) (50”g/kg)+L-NAME group received SNP before L-NAME and 4-6) three groups of Z. jujuba (100, 200 and 400mg/kg) that treated for four weeks and on the 28th day, L-NAME was injected. Femoral artery and vein were cannulated for recording cardiovascular responses and drug injection, respectively. Systolic blood pressure (SBP), Mean arterial pressure (MAP) and heart rate (HR) were recorded continuously. Maximal changes (â) of SBP, MAP and HR were calculated and compared to control and L-NAME groups. Results: In L-NAME group, maximal ÎSBP (L-NAME: 44.15±4.0 mmHg vs control: 0.71±2.1 mmHg) and ÎMAP (L-NAME: 40.8±4.0 mmHg vs control: 0.57±1.6 mmHg) significantly increased (p0.05). All doses of Z. jujuba attenuated maximal âSBP and âMAP induced by L-NAME but only the lowest dose (100 mg/kg) had significant effects (ÎSBP: 20.36±5.6 mmHg vs L-NAME: 44.1±4.0 mmHg and ÎMAP: 20.8±4.5 mmHg vs L-NAME: 40.8±3.8 mmHg (p0.05). Conclusion: Because long-term consumption of Z. jujuba extract, especially its lowest dose, attenuated cardiovascular responses induced by L-NAME, we suggest that Z. jujuba has potential beneficial effects in prevention of hypertension induced by NO deficiency
Lipopolysaccharide-induced memory impairment in rats is preventable using 7-nitroindazole O dĂ©ficit de memĂłria induzido por lipossacarĂdeos em ratos Ă© prevenido por nitroindazol
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