British Association of dermatologists guidelines for biologic therapy for psoriasis 2020 – a rapid update

The overall aim of the guideline is to provide up‐to‐date, evidence‐based recommendations on the use of biologic therapies targeting TNF (adalimumab, etanercept, certolizumab pegol, infliximab), IL12/23p40 (ustekinumab), IL17A (ixekizumab, secukinumab), IL17RA (brodalumab) and IL23p19 (guselkumab, risankizumab, tildrakizumab) in adults, children and young people for the treatment of psoriasis; consideration is given to the specific needs of people with psoriasis and psoriatic arthritis

British Association of Dermatologists guidelines for the management of people with vitiligo 2021

The overall objective of the guideline is to provide up-to-date, evidence-based recommendations for the management of vitiligo. The document aims to: offer an appraisal of all relevant literature up to May 2019, focusing on any key developments address important, practical clinical questions relating to the primary guideline objective provide guideline recommendations and if appropriate research recommendations

Low power ROM Employing Dynamic Threshold-Voltage MOSFET (DTMOS) Technique

This paper examines the performance of two 128-bit ROM circuits, implemented on Silterra 0.18u CMOS process. The first circuit is built using standard NMOS transistors, runs on 0.9V supply voltage, has gate voltage of 0.45V and consumes 102.07 mu W power. The second circuit is designed partly using Dynamic Threshold-Voltage MOSFET (DTMOS) transistors with the aim to minimize power consumption. It runs on 0.7V supply and has gate voltage of 0.35V. The DTMOS approach is implemented on the 128-bit ROM core and in the pull up circuit of the column decoder. The latter ROM circuit's power consumption is 38.93 mu W, 61.86% less than the former, at the expenses of larger die area due to the usage of deep n-well process. The standard and DTMOST circuits have the die areas of 0.139 mu m2 and 0.235 mu m2, respectively

Development of vehicle model test-bending of a simple structural surfaces model for automotive vehicle sedan

Simple Structural Surfaces (SSS) method is offered as a means of organizing the process for rationalizing the basic vehicle body structure load paths. The application of this simplified approach is highly beneficial in the development of modern passenger car structure design. In Malaysia, the SSS topic has been widely adopted and seems compulsory in various automotive programs related to automotive vehicle structures in many higher education institutions. However, there is no real physical model of SSS available to gain considerable insight and understanding into the function of each major subassembly in the whole vehicle structures. Based on this motivation, a real physical SSS of sedan model and the corresponding model vehicle tests of bending is proposed in this work. The proposed approach is relatively easy to understand as compared to Finite Element Method (FEM). The results prove that the proposed vehicle model test is useful to physically demonstrate the importance of providing continuous load path using the necessary structural components within the vehicle structures. It is clearly observed that the global bending stiffness reduce significantly when more panels are removed from the complete SSS model. The analysis shows the front parcel shelf is an important subassembly to sustain bending load

The compliance of road users with the speed limit at school zones on federal road ft50 (km0-km23)

Driving speed at school zone is an important concern on road safety. In Malaysia, the speed limit of 30km/hr is mandatory at school zone. Thus, this study aims to investigate the compliance of road users towards the speed limit and the signage at school zone and determine the factors of non- compliance. The research was conducted along the Federal Road of Batu Pahat and Ayer Hitam Johor FT050 (KM0-KM23) where 7 schools were situated. Methods used are spot speed and site visit as well as obtaining the road accident statistics from the Royal Malaysian Police. The data collected was analysed, those above 85th percentile speed and below 15th percentile speed did not comply with the speed limit imposed 30km/hr signs. The results show most of the road users failed to obey the 30kn/hr speed limit at all the study locations and the factor affecting this are aggressive driving and signage not meeting the required standards. As consequences, there in an increasing trend of road accidents along FT050