A Critical Review on Chandraprabha Vati - An Ayurvedic Formulation

Herbal and herbo-mineral medicines are been widely used in Ayurveda. It has mentioned indications covering in a broader way. Rasa Oushadhi plays an important role in Ayurveda because of its rejuvenating property along with it provides immunization, long shelf life, and greater efficacy even when given in a low dose. One such classical multi-ingredient herbo- mineral Ayurvedic formulation is Chandraprabha Vati. It has many pharmaco-therapeutical applications. It is formulated with broad spectrum activity and is indicated in various diseases like Prameha, Arbudha, Artava, Mutra Vikaras, Arshas etc. Many formulations are mentioned in the name of Chandraprabha Vati. Chandraprabha Vati is Rasayana, Balya, Tridosha Shamaka properties and also acts as catalyst. It is truly a medicine for all diseases and hence called as Sarvaroga Pranashini and is also been used in ailments of reproductive health in both men and women. Certain researches have been done regarding its hypotensive and hypoglycemic properties. It also provides immunity and strength to the body due to Rasayana. In this study an attempt is made to gather and analyze the formulation having different varieties of Chandraprabha Vati from various classics along with its insight in their ingredients, dosage, indication and mode of action and its applications

Discovery of a hot post-AGB star in Galactic globular cluster E3

We report a new hot post-asymptotic giant branch (PAGB) star in the Galactic globular cluster (GC) E3, which is one of the first of the identified PAGB stars in a GC to show a binary signature. The star stands out as the brightest source in E3 in the \mbox{{\em Astrosat}}/UVIT images. We confirmed its membership with the cluster E3 using Gaia DR3 kinematics and parallax measurements. We supplemented the photometric observations with radial velocities (RVs) from high-resolution spectroscopic observations at two epochs and with ground- and space-based photometric observations from 0.13 $\mu$m to 22 $\mu$m. We find that the RVs vary over $\sim$6 \kms\ between the two epochs. This is an indication of the star being in a binary orbit. A simulation of possible binary systems with the observed RVs suggests a binary period of either 39.12 days or 17.83 days with mass ratio q$\geq$1.0. The [Fe/H] derived using the high-resolution spectra is $\sim -$0.7 dex, which closely matches the cluster metallicity. The spectroscopic and photometric measurements suggest \Teff\ and $\log g$ of the star as 17\,500$\pm$1\,000~K and 2.37$\pm$0.20~dex, respectively. Various PAGB evolutionary tracks on the Hertzsprung--Russell (H-R) diagram suggest a current mass of the star in the range 0.51$-$0.55 \Msun. The star is enriched with C and O abundances, showing similar CNO abundances compared to the other PAGB stars in GCs with the evidence of the third dredge-up on the AGB phase.Comment: Published in A&A Letters, Published Versio

Holocene dune activity in the Thar Desert, India

The Thar Desert dune system in north-west India and eastern Pakistan provides a rich archive of past environmental, geomorphological and climatic change. Much of the knowledge about the timing of dune accumulation in the Thar stems from scattered and sporadic records, based on older luminescence dating protocols. If the Thar dune record is to be incorporated within a growing multiproxy framework of past climate and environmental dynamics, it is necessary to generate a systematic record of the timing of dunefield accumulation. From this, relationships to climate and other drivers of dune activity may then be better established. To this end, an intensive programme of field sampling and optically stimulated luminescence (OSL) dating was carried out from a dunefield in the east-central Thar Desert. This study presents the first detailed Holocene dune accumulation history from the region, and sheds light on the development of the multi-generational parabolic dune systems. In contrast to previously published work, we identify the importance of the Holocene and the last millennium as periods with a number of preserved accumulation phases. OSL ages suggest that accumulation was persistent during the early and mid-Holocene (within 11.7-5.5 ka), late Holocene (2-1 ka), as well as two major phases in the last millennium (600 – 200 a and within the last 70 a). Potential drivers of dune mobility in the last century include a strong anthropogenic dimension. Rapid net accumulation is recorded in the last 70 years, with rates varying between 2 and 5 m/year, in an environment where agricultural pressures have increased dramatically with the advent of irrigation schemes expanding into dunefield areas. © 2019 John Wiley & Sons, Ltd

Comprehensive spectroscopic and photometric study of pulsating eclipsing binary star AI Hya

The pulsating eclipsing binaries are remarkable systems that provide an opportunity to probe the stellar interior and to determine the fundamental stellar parameters precisely. Especially the detached eclipsing binary systems with (a) pulsating component(s) are significant objects to understand the nature of the oscillations since the binary effects in these systems are negligible. Recent studies based on space data have shown that the pulsation mechanisms of some oscillating stars are not completely understood. Hence, comprehensive studies of a number of pulsating stars within detached eclipsing binaries are important. In this study, we present a detailed analysis of the pulsating detached eclipsing binary system AI Hya which was studied by two independent groups with different methods. We carried out a spectroscopic survey to estimate the orbital parameters via radial velocity measurements and the atmospheric parameters of each binary component using the composite and/or disentangled spectra. We found that the more luminous component of the system is a massive, cool and chemically normal star while the hotter binary component is a slightly metal-rich object. The fundamental parameters of AI Hya were determined by the analysis of binary variations and subsequently used in the evolutionary modelling. Consequently, we obtained the age of the system as 850 $\pm$ 20 Myr and found that both binary components are situated in the Delta Scuti instability strip. The frequency analysis revealed pulsation frequencies between the 5.5 - 13.0 d$^{-1}$ and we tried to estimate which binary component is the pulsating one. However, it turned out that those frequencies could originate from both binary components.Comment: Accepted for publication in MNRA

Small-scale cosmic ray anisotropy observed by the GRAPES-3 experiment at TeV energies

GRAPES-3 is a mid-altitude (2200 m) and near equatorial ($11.4^{\circ}$ North) air shower array, overlapping in its field of view for cosmic ray observations with experiments that are located in Northern and Southern hemispheres. We analyze a sample of $3.7\times10^9$ cosmic ray events collected by the GRAPES-3 experiment between 1 January 2013 and 31 December 2016 with a median energy of $\sim16$ TeV for study of small-scale ($<60^{\circ}$) angular scale anisotropies. We observed two structures labeled as A and B, deviate from the expected isotropic distribution of cosmic rays in a statistically significant manner. Structure `A' spans $50^{\circ}$ to $80^{\circ}$ in the right ascension and $-15^{\circ}$ to $30^{\circ}$ in the declination coordinate. The relative excess observed in the structure A is at the level of $(6.5\pm1.3)\times10^{-4}$ with a statistical significance of 6.8 standard deviations. Structure `B' is observed in the right ascension range of $110^{\circ}$ to $140^{\circ}$. The relative excess observed in this region is at the level of $(4.9\pm1.4)\times10^{-4}$ with a statistical significance of 4.7 standard deviations. These structures are consistent with those reported by Milagro, ARGO-YBJ, and HAWC. These observations could provide a better understanding of the cosmic ray sources, propagation and the magnetic structures in our Galaxy

Clinical features and outcomes of patients with tubercular uveitis treated with antitubercular therapy in the collaborative ocular tuberculosis study (COTS)-1

IMPORTANCE Eradication of systemic tuberculosis (TB) has been limited by neglected populations and the HIV pandemic. Whereas ocular TB often presents as uveitis without any prior evidence of systemic TB, the existing uncertainty in the diagnosis of TB uveitis may perpetuate missed opportunities to address systemic TB. OBJECTIVE To examine the clinical features of TB uveitis and the associations with response to antitubercular therapy (ATT). DESIGN, SETTING, AND PARTICIPANTS This retrospective multinational cohort study included patients from 25 ophthalmology referral centers diagnosed with TB uveitis and treated with ATT from January 1, 2004, through December 31, 2014, with a minimum follow-up of 1 year. MAIN OUTCOMES AND MEASURES Treatment failure, defined as a persistence or recurrence of inflammation within 6 months of completing ATT, inability to taper oral corticosteroids to less than 10mg/d or topical corticosteroid drops to less than 2 drops daily, and/or recalcitrant inflammation necessitating corticosteroid-sparing immunosuppressive therapy. RESULTS A total of 801 patients (1272 eyes) were studied (mean [SD] age, 40.5 [14.8] years; 413 [51.6%] male and 388 [48.4%] female; 577 [73.6%] Asian). Most patients had no known history (498 of 661 [75.3%]) of systemic TB. Most patients had bilateral involvement (471 of 801 [58.8%]). Common clinical signs reported include vitreous haze (523 of 1153 [45.4%]), retinal vasculitis (374 of 874 [42.8%]), and choroidal involvement (419 of 651 [64.4%]). Treatment failure developed in 102 of the 801 patients (12.7%). On univariate regression analysis, the hazard ratios (HRs) associated with intermediate uveitis (HR, 2.21; 95%CI, 1.07-4.55; P = .03), anterior uveitis (HR, 2.68; 95%CI, 1.32-2.35; P = .006), and panuveitis (HR, 3.28; 95%CI, 1.89-5.67; P &lt; .001) were significantly higher compared with posterior distribution. The presence of vitreous haze had a statistically significant association (HR, 1.95; 95%CI, 1.26-3.02; P = .003) compared with absence of vitreous haze. Bilaterality had an associated HR of 1.50 (95%CI, 0.96-2.35) compared with unilaterality (HR, 1 [reference]), although this finding was not statistically significant (P = .07). On multivariate Cox proportional hazards regression analysis, the presence of vitreous haze had an adjusted HR of 2.98 (95%CI, 1.50-5.94; P = .002), presence of snow banking had an adjusted HR of 3.71 (95%CI, 1.18-11.62; P = .02), and presence of choroidal involvement had an adjusted HR of 2.88 (95%CI, 1.22-6.78; P = .02). CONCLUSIONS AND RELEVANCE A low treatment failure rate occurred in patients with TB uveitis treated with ATT. Phenotypes and test results are studied whereby patients with panuveitis having vitreous and choroidal involvement had a higher risk of treatment failure. These findings are limited by retrospectivemethods. A prospectively derived composite clinical risk score might address this diagnostic uncertainty through holistic and standardized assessment of the combinations of clinical features and investigation results that may warrant diagnosis of TB uveitis and treatment with ATT

Directionality of nuclear recoils in a liquid argon time projection chamber

The direct search for dark matter in the form of weakly interacting massive particles (WIMP) is performed by detecting nuclear recoils (NR) produced in a target material from the WIMP elastic scattering. A promising experimental strategy for direct dark matter search employs argon dual-phase time projection chambers (TPC). One of the advantages of the TPC is the capability to detect both the scintillation and charge signals produced by NRs. Furthermore, the existence of a drift electric field in the TPC breaks the rotational symmetry: the angle between the drift field and the momentum of the recoiling nucleus can potentially affect the charge recombination probability in liquid argon and then the relative balance between the two signal channels. This fact could make the detector sensitive to the directionality of the WIMP-induced signal, enabling unmistakable annual and daily modulation signatures for future searches aiming for discovery. The Recoil Directionality (ReD) experiment was designed to probe for such directional sensitivity. The TPC of ReD was irradiated with neutrons at the INFN Laboratori Nazionali del Sud, and data were taken with 72 keV NRs of known recoil directions. The direction-dependent liquid argon charge recombination model by Cataudella et al. was adopted and a likelihood statistical analysis was performed, which gave no indications of significant dependence of the detector response to the recoil direction. The aspect ratio R of the initial ionization cloud is estimated to be 1.037 +/- 0.027 and the upper limit is R < 1.072 with 90% confidence levelComment: 20 pages, 10 figures, submitted to Eur. Phys. J.

Study on cosmogenic activation above ground for the DarkSide-20k project

The activation of materials due to the exposure to cosmic rays may become an important background source for experiments investigating rare event phenomena. DarkSide-20k is a direct detection experiment for galactic dark matter particles, using a two-phase liquid argon time projection chamber filled with 49.7 tonnes (active mass) of Underground Argon (UAr) depleted in 39Ar. Here, the cosmogenic activity of relevant long-lived radioisotopes induced in the argon and other massive components of the set-up has been estimated; production of 120 t of radiopure UAr is foreseen. The expected exposure above ground and production rates, either measured or calculated, have been considered. From the simulated counting rates in the detector due to cosmogenic isotopes, it is concluded that activation in copper and stainless steel is not problematic. Activation of titanium, considered in early designs but not used in the final design, is discussed. The activity of 39Ar induced during extraction, purification and transport on surface, in baseline conditions, is evaluated to be 2.8% of the activity measured in UAr from the same source, and thus considered acceptable. Other products in the UAr such as 37Ar and 3H are shown to not be relevant due to short half-life and assumed purification methods

Sensitivity projections for a dual-phase argon TPC optimized for light dark matter searches through the ionization channel

Dark matter lighter than 10 GeV/c$^2$ encompasses a promising range of candidates. A conceptual design for a new detector, DarkSide-LowMass, is presented, based on the DarkSide-50 detector and progress toward DarkSide-20k, optimized for a low-threshold electron-counting measurement. Sensitivity to light dark matter is explored for various potential energy thresholds and background rates. These studies show that DarkSide-LowMass can achieve sensitivity to light dark matter down to the solar neutrino floor for GeV-scale masses and significant sensitivity down to 10 MeV/c$^2$ considering the Migdal effect or interactions with electrons. Requirements for optimizing the detector's sensitivity are explored, as are potential sensitivity gains from modeling and mitigating spurious electron backgrounds that may dominate the signal at the lowest energies

Measurement of isotopic separation of argon with the prototype of the cryogenic distillation plant Aria for dark matter searches

The Aria cryogenic distillation plant, located in Sardinia, Italy, is a key component of the DarkSide-20k experimental program for WIMP dark matter searches at the INFN Laboratori Nazionali del Gran Sasso, Italy. Aria is designed to purify the argon, extracted from underground wells in Colorado, USA, and used as the DarkSide-20k target material, to detector-grade quality. In this paper, we report the first measurement of argon isotopic separation by distillation with the 26&nbsp;m tall Aria prototype. We discuss the measurement of the operating parameters of the column and the observation of the simultaneous separation of the three stable argon isotopes: 36Ar , 38Ar , and 40Ar . We also provide a detailed comparison of the experimental results with commercial process simulation software. This measurement of isotopic separation of argon is a significant achievement for the project, building on the success of the initial demonstration of isotopic separation of nitrogen using the same equipment in 2019