Respiratory dyskinesia--an under-recognized side-effect of neuroleptic medications

Respiratory dyskinesia is an under-recognized side effect of neuroleptic administration. There are only few studies that have addressed the prevalence of respiratory dyskinesia in patients with tardive dyskinesia. Our case report highlights the need to regularly examine patients on antipsychotics for any evidence of dyskinetic movements including respiratory musculature. Since RD is underrecognized and misdiagnosed, early detection can improve long term prognosis as treatment options are few and usually of only limited effect. A 62-year-old Asian male, retired civil engineer, had more than 20 years history of depressive illness, developed antidepressant induced hypomania, and was given risperidone upto 1 mg per day. He developed extrapyrmidal side effects as tremors, rigidity and later dyskinetic movements of lips with shortness of breathing, dyspnoea, grunting or gasping. He was referred to the pulmonologist who got the neccessary medical work up done, which was normal. A diagnosis of respiratory dyskinesia was made. Respiratory dyskinesia is an under-recognised and distressing condition that clinicians need to be aware of when treating patients with anti-psychotic medications. And also there is a need to regularly examine patients on antipsychotics for any evidence of dyskinetic movements including respiratory musculature for early diagnosis and better outcome. This case report also is worth reading for professionals of other specialties also because of the presentation of this patient, it can be easily misdiagnosed and result in poor outcome

Use of ‘Skill Development’ in ‘One District One Product’ Scheme: An Analytical Study

In order to promote the development of micro, small and medium industries, and inclusive economic development, the 'One District One Product' scheme was started in Uttar Pradesh with the help of the Central Government. The research paper, by linking this scheme with another scheme of the Central Government, 'Skill Development, to accelerate the development and ODOP. The possibility of taking the success of the scheme to the highest level has been explored

Behavioural Fault tolerant control of an Omni directional Mobile Robot with Four mecanum Wheels

This paper analyses the four-mecanum wheeled drive mobile robot wheels configurations that will give near desired performance with one fault and two faults for both set-point control and trajectory-tracking (circular profile) using kinematic motion control scheme within the tolerance limit. For one fault the system remains in its full actuation capabilities and gives the desired performance with the same control scheme. In case of two-fault wheels all combinations of faulty wheels have been considered using the same control scheme. Some configurations give desired performance within the tolerance limit defined while some does not even use pseudo inverse since using the system becomes under-actuated and their wheel alignment and configurations greatly influenced the performance

Phenotypic detection of Metallo Beta Lactamase Producing Pseudomonas aeruginosa among Clinical Isolates from the intensive care unit of a tertiary care centre

Background: Pseudomonas aeruginosa is an opportunistic pathogenic bacterium responsible for both, acute and chronic infection, causing serious infections in patients who are mechanically ventilated individuals, who are immunocompromised, and patients with malignancies or HIV infection. Objectives: The phenotypic screening of metallo beta-lactamases (MBL) in strains of Pseudomonas aeruginosa resistant to imipenem. Material and Methods: The study was carried out in the department of Microbiology, in a medical hospital, Bareilly, over a period 18 months from January 2013 to June 2014. A total of 103 Pseudomonas aeruginosa isolated from sputum, broncho alveolar lavage (BAL), urine, pus and blood from critically ill patients admitted in the intensive care unit of a tertiary care centre. Strain of P. aeruginosa resistant to imipenem, were tested for metallo beta-lactamase production by phenotypic methods. Result: Out of 103 Pseudomonas aeruginosa, 48 strains were found imipenem resistant, of which 43(89.6%) were MBL positive by imipenem -EDTA combined disc test and the rest 35(72.9%) were by modified Hodge test. Conclusion: Imipenem – EDTA combined disc test found to be the best phenotypic method for detection of MBL. The appearance of the MBL and their spread among bacterial pathogens is a matter of concern with regard to the future of antimicrobial therapy. Both the methods are simple and one of these phenotypic methods can be easily incorporated in routine lab procedures to detect MBL

Anti-hyperlipidaemic effects of fresh and cured Bhallataka Kshaudra (Semecarpus anacardium L.) in animals

Bhallataka Phala (fruit of Semecarpus anacardium L.), is a well-known anti-hyperlipidaemic drug. Bhallataka is described in all Ayurvedic classics as Rasayana and advocated for various therapeutic purposes such as Kushtha (skin diseases), Arsha (piles), Krimi (worm infestations), Prameha (urine disorders), Medodosha (lipid disorders), etc. Though its anti-hyperlipidaemic activity has been studied; actual differentiation in their therapeutic efficacy due to storage period has yet not been attempted on experimental animals. This prompted to initiate a comparative anti-hyperlipidemic activity of fixed oil (expressed oil) i.e. non-volatile in nature collected from fresh Bhallataka and four months old (cured) Bhallataka samples against cholesterol diet induced hyperlipidaemia in rats. Hyperlipidemia was induced by oral administration of cholesterol (20 % suspension in coconut oil, 5 mL/kg) in morning hours and hydrogenated vegetable oil (5 mL/kg) in evening. The effect of drugs was assessed on body weight, serum biochemical and histological parameters. Both drugs produced significant attenuation of the relative weight of liver in cholesterol-fed animals. Cured sample of Bhallataka provided better effect in lowering serum cholesterol (21.98 %), triglyceride (60.23 %), VLDL (56.82 %); while fresh sample of Bhallataka also found to be effective in lowering serum cholesterol (20.69 %), serum triglyceride (45.59 %), VLDL (46.59 %) in comparison to control group. From the result of the present study, it is concluded that the cured sample of Bhallataka has pronounced anti-hyperlipidemic effect than the fresh sample in experimentally-induced hyperlipidemia in rats

Hemangiopericytoma of the spleen: Unusual presentation as multiple abscess

BACKGROUND: Hemangiopericytoma is a soft tissue vascular neoplasm arising from capillary pericytes and is found throughout the body in soft tissues and bone. It was first described in 1942. Primary vascular neoplasm of the spleen constitutes the majority of nonhaematolymphoid splenic tumors like haemangioma, lymphangioma, hemangioendothelioma, hemangiopericytoma etc. Splenic hemangiopericytoma is a rare tumor and probably first case was described in 1989. Uptill now only eight cases are reported in the English literature. CASE PRESENTATION: A-35-year old male presented with fever and dull aching pain in left hypochondriac region. Radiological evaluation showed presence of multiple abscesses in spleen. Investigations were done to rule out common causes of abscess in spleen. After failure of medical management, he was subjected to elective splenectomy. There were dense adhesions between the spleen and the adjacent structures and the diaphragm. The histopathology of the resected specimen showed hemangiopericytoma of spleen. CONCLUSION: The present case illustrate that the hemangiopericytoma of spleen can mimic as multiple abscess. Splenectomy is the treatment of choice

Analysis of Behavioral Characteristics of Jammers to Detect Malicious Nodes in Mobile ADHOC Networks

Wireless ADHOC Networks are used to establish a wireless connection between two computing devices without the need for a Wi-Fi access point or router. This network is decentralized and uses omnidirectional communication media, which makes it more vulnerable to certain types of attacks compared to wired networks. Jamming attacks, a subset of denial-of-service (DoS) attacks, involve malicious nodes that intentionally interfere with the network, blocking legitimate communication. To address this issue, the proposed method analyzes various characteristics of nodes, such as packets sent, received, and dropped, at each node. Using the packet delivery ratio and packet drop ratio, the method detects jamming nodes from normal nodes, improving network performance. The network is simulated in NS2 environment

Nietypowy elektrokardiograficzny zapis zaburzeń przewodzenia po zastosowaniu chlorochiny — opis rzadkiego przypadku

23-year-old man presented with Stokes-Adams attacks due to sinus node dysfunction. He was being treated for malaria with chloroquine for the last two days. Temporary pacemaker was implanted. Subsequently he developed all spectrum of atrioventricular block following recovery of sinus node dysfunction which also recovered on the fi fteenth day and was discharged. Cardiac damage, such as cardiomyopathy and conduction system disturbances, is regarded as uncommon consequences of acute chloroquines’s toxicity. Here we present a case in which chloroquine used as acute therapy for malaria resulted in conduction disorder beginning from sinus node dysfunction to Mobitz I atrioventricular block to complete heart block with recovery to normal sinus rhythm in single patient.Mężczyzna w wieku 23 lat zgłosił się do lekarza z powodu napadów Morgagniego-Adamsa-Stokesa będących następstwem dysfunkcji węzła zatokowego. Przez ostatnie 2 dni stosował chlorochinę w ramach leczenia przeciwmalarycznego. Tymczasowo wszczepiono mu stymulator serca. Po ustąpieniu zaburzeń węzła zatokowego u chorego rozwinął się pełny blok przedsionkowo-komorowy, który również ustąpił po 15 dniach i chorego wypisano do domu. Uszkodzenie serca w postaci kardiomiopatii lub zaburzeń przewodzenia jest rzadkim następstwem ostrego toksycznego działania chlorochiny. W artykule przedstawiono przypadek pacjenta, u którego po zastosowaniu chlorochiny w leczeniu ostrego napadu malarii wystąpiło całe spektrum zaburzeń przewodzenia — od dysfunkcji węzła zatokowego, przez blok przedsionkowo-komorowy typu Mobitz I, do całkowitego bloku przedsionkowo komorowego — zakończonych przywróceniem prawidłowego rytmu zatokowego