Attention to Human Dignity and Its Role in Increasing Spirituality

The main purpose of this paper is to investigate about the dignity of human and its role in increasing the spirituality in light of Islam. The founding shows that spirituality has been considered as a desirable thing throughout humans’ life and lots of effort have been made to strengthen it. There are several factors that raise and cultivate spirituality, but among these factors, human dignity has essential role and basis. In this research, while explaining the concept of spirituality, the importance of human dignity in creating a spiritual personality is emphasized, and how the influence of human dignity in increasing spirituality will also be investigated, and it is proven that the source of spirituality is paying attention to inherent and deprivations, neglect and lack of attention to the position and dignity of the royal soul of man

Patch clamp studies on TRPV4-dependent hemichannel activation in lens epithelium

ATP release from the lens via hemichannels has been explained as a response to TRPV4 activation when the lens is subjected to osmotic swelling. To explore the apparent linkage between TRPV4 activation and connexin hemichannel opening we performed patch-clamp recordings on cultured mouse lens epithelial cells exposed to the TRPV4 agonist GSK1016790A (GSK) in the presence or absence of the TRPV4 antagonist HC067047 (HC). GSK was found to cause a fast, variable and generally large non-selective increase of whole cell membrane conductance evident as a larger membrane current (Im) over a wide voltage range. The response was prevented by HC. The GSK-induced Im increase was proportionally larger at negative voltages and coincided with fast depolarization and the simultaneous disappearance of an outward current, likely a K+ current. The presence of this outward current in control conditions appeared to be a reliable predictor of a cell’s response to GSK treatment. In some studies, recordings were obtained from single cells by combining cell-attached and whole-cell patch clamp configurations. This approach revealed events with a channel conductance 180–270 pS following GSK application through the patch pipette on the cell-attached side. The findings are consistent with TRPV4-dependent opening of Cx43 hemichannels

Functionally Active T1-T1 Interfaces Revealed by the Accessibility of Intracellular Thiolate Groups in Kv4 Channels

Gating of voltage-dependent K+ channels involves movements of membrane-spanning regions that control the opening of the pore. Much less is known, however, about the contributions of large intracellular channel domains to the conformational changes that underlie gating. Here, we investigated the functional role of intracellular regions in Kv4 channels by probing relevant cysteines with thiol-specific reagents. We find that reagent application to the intracellular side of inside-out patches results in time-dependent irreversible inhibition of Kv4.1 and Kv4.3 currents. In the absence or presence of Kv4-specific auxiliary subunits, mutational and electrophysiological analyses showed that none of the 14 intracellular cysteines is essential for channel gating. C110, C131, and C132 in the intersubunit interface of the tetramerization domain (T1) are targets responsible for the irreversible inhibition by a methanethiosulfonate derivative (MTSET). This result is surprising because structural studies of Kv4-T1 crystals predicted protection of the targeted thiolate groups by constitutive high-affinity Zn2+ coordination. Also, added Zn2+ or a potent Zn2+ chelator (TPEN) does not significantly modulate the accessibility of MTSET to C110, C131, or C132; and furthermore, when the three critical cysteines remained as possible targets, the MTSET modification rate of the activated state is ∼200-fold faster than that of the resting state. Biochemical experiments confirmed the chemical modification of the intact α-subunit and the purified tetrameric T1 domain by MTS reagents. These results conclusively demonstrate that the T1–T1 interface of Kv4 channels is functionally active and dynamic, and that critical reactive thiolate groups in this interface may not be protected by Zn2+ binding

Psychiatric disorders among the children of 5 to 18 years old of 'SIDR' affected areas

Background: Natural disasters give raise a significant amount of physical and mental impairment in human beings. Any sort of disaster acts as a causative and maintaining factor for any psychiatric morbidity. In November 15, 2007, the cyclone "SIDR" intensified to reach peak winds of 215 km/h (135 mph) according to the IMD, a peak of 250 km/h (155 mph) according to the JTWC. "SIDR" officially made landfall around 1700 UTC later that day, with sustained winds of 215 km/h (135 mph). As it intensified to a Category 4-equivalent cyclone and thus coastal districts of Bangladesh faced heavy rainfall as an early impact of the cyclone. The damage in Bangladesh was extensive, including tin shacks flattened, houses and schools blown away and enormous tree damage. The entire cities of Patuakhali, Barguna and Jhalokati District were hit hard by the storm surge of over 5 meters ( 16 ft). The head of the Red Crescent in Bangladesh expects the death toll to reach as high as 10,000. Over 3,000 other fishermen were reported missing on over 500 fishing boats. The "SIDR" left its strong impact on those who survived. Objectives: The Study was aimed to estimate the prevalence of psychiatric disorder among children and adolescents in the "SIDR" affected areas. Method: This was cross sectional, qualitative study done among the children and adolescent groups of 5 to 18 years old to see the effect of natural disaster on the people of southern part of Bangladesh. The whole of the children population who attended in the health camp were included in the study during the study period. Three teams have worked among the four "SIDR" affected districts. Each team consists of Psychiatrists, General Physicians, and Clinical Psychologist.Results: A total of 158 children in four defined areas revealed that the prevalence rate of psychiatric disorder was 48%.Conclusion: This type of study should be done in multi-centers in SIDR affected disti.icts of Bangladesh to find out the actual prevalence rate of child and adolescent psychiatric disorder

Regeneration potential of seedling explants of chilli (Capsicum annuum)

A study was conducted with hypocotyl, cotyledon and shoot tip of chilli as explants for regeneration on MS medium supplemented with different concentrations and combinations of auxins and cytokinins. Regeneration potential was determined by two ways. One is regeneration of shoot via callus formation from hypocotyls and cotyledon explants; another was direct shoot regeneration from shoot tip explant. The highest callus was induced from hypocotyl in a combination of BAP (5.0 mgL-1) with NAA (0.1 mgL-1) and cotyledon in a combination of BAP (5.0 mgL-1) with IAA ((1.0 mgL-1). The callus induction as well as shoot initiation was higher in hypocotyls than cotyledon. Shoot tips regenerated into plantlets directly with sporadic small callus at the base. Shoot elongation was accelerated by using additional supplementation of GA3 and AgNO3. Regenerated shoots rooted best on the MS medium supplemented with 0.1 mg L-1 NAA + 0.05 mg L-1 IBA

Role of Hematologic Scoring System in Early Diagnosis of Neonatal Septicemia

Background: Neonatal septicemia is one of the major health problems throughout the world. Infections are a frequent and important cause of morbidity and mortality in neonatal period. Objective: The objective of this study was the role of hematologic scoring system (HSS) in the early diagnosis of neonatal septicemia. Methods: This is a prospective study consisted of 100 neonates admitted at neonatal ICU, BSMMU, who were clinically suspected cases of septicemia. The neonatal hematological parameter was measured in all cases. Blood culture was done for the gold standard of proven sepsis. There were 12 out of 100 neonates (12%) who had culture proven sepsis. They were predominantly preterm and of very low birth weight. Results: On evaluation of various hematological parameters total leucocytes count, total neutrophil count, IT ratio (>0.2), IM ratio (> 0.3), total immature PMNs count, platelet count were found to have optimal sensitivities and negative predictive values. Using these values hematologic scoring system was formulated according to Rodwell et al. Score > 4 has a sensitivity of 100%, specificity of 60%, with PPV 26% and NPV 100 %. Considering the high sensitivity, negative predictive value, this study implies that score > 4 were more reliable as a screening tool for sepsis than any of the individual hematological parameter. Conclusion: HSS are useful test to distinguish the infected from non infected infants. They also provide a effective guideline to make decisions regarding judicious use of antibiotic therapy.Keywords: Hematologic scoring system (HSS); Blood culture; Neonatal septicemia DOI: 10.3329/bsmmuj.v3i2.7053BSMMU J 2010; 3(2): 62-6

Role of Hematologic Scoring System in Early Diagnosis of Neonatal Septicemia

Background: Neonatal septicemia is one of the major health problems throughout the world. Infections are a frequent and important cause of morbidity and mortality in neonatal period. Objective: The objective of this study was the role of hematologic scoring system (HSS) in the early diagnosis of neonatal septicemia. Methods: This is a prospective study consisted of 100 neonates admitted at neonatal ICU, BSMMU, who were clinically suspected cases of septicemia. The neonatal hematological parameter was measured in all cases. Blood culture was done for the gold standard of proven sepsis. There were 12 out of 100 neonates (12%) who had culture proven sepsis. They were predominantly preterm and of very low birth weight. Results: On evaluation of various hematological parameters total leucocytes count, total neutrophil count, IT ratio (>0.2), IM ratio (> 0.3), total immature PMNs count, platelet count were found to have optimal sensitivities and negative predictive values. Using these values hematologic scoring system was formulated according to Rodwell et al. Score > 4 has a sensitivity of 100%, specificity of 60%, with PPV 26% and NPV 100 %. Considering the high sensitivity, negative predictive value, this study implies that score > 4 were more reliable as a screening tool for sepsis than any of the individual hematological parameter. Conclusion: HSS are useful test to distinguish the infected from non infected infants. They also provide a effective guideline to make decisions regarding judicious use of antibiotic therapy.Keywords: Hematologic scoring system (HSS); Blood culture; Neonatal septicemia DOI: 10.3329/bsmmuj.v3i2.7053BSMMU J 2010; 3(2): 62-6

An icteric newborn with bad obstetric history

This article has no abstract. The first 100 words appear below:A 34 week preterm baby was admitted with the complaints of respiratory distress soon after birth. The mother had bad obstetric history. She is having the fifth gravida with the first two alive and healthy who were born by the normal vaginal delivery at home. The third child was born with severe jaundice and was treated by exchange transfusion. Subsequently the baby developed bilirubin encephalopathy. Then the baby developed cerebral palsy and ultimately died due to aspiration pneumonia at the age of 2.5 years. Her first three pregnancies were not on any antenatal check-up by the health care provider due to poor socio-economic background and illiteracy