Idiopathic Perforation of the Sigmoid Colon in a 2.5 Years Old Girl: A Case Report

Idiopathic colon perforation is rare in children. It is more common at the extremes of age. Splenic flextures, ileocecal and lower sigmoid regions are the most common sites of perforation. Delay in proper management of this condition is associated with high mortality and morbidity rate. We report on the case of a 2.5 years old girl who presented with fever, diarrhea, nausea and vomiting and progressive abdominal distention.Finally, she underwent an exploratory laparotomy for suspected peritonitis because of the patient's worsening condition. An area of perforation was found in the sigmoid colon that segmental resection and an end double barrel colostomy was done

Autoimmune thyroid disease in northern Iranian children with type 1 diabetes mellitus in Amirkola Endocrine Clinic

Background: Type 1 diabetes mellitus (T1DM) as an autoimmune disorder is associated with other autoimmune diseases such as autoimmune thyroid (AIT) disease. The aim of this study was to determine the prevalence of AIT in children who were referred to Amirkola Endocrine Clinic (north of Iran). Methods: This cross-sectional study was carried out on 100 diabetic children aged 1-15 years during 2008-2013, who were referred to the pediatric endocrine clinic. Serum levels of anti-thyroid peroxidase (Anti-TPO) and anti-thyroglobulin (anti-Tg) antibodies and Thyrotropin Stimulating Hormone (TSH) were measured by Immune Chemiluminescence assay, and demographic information was obtained from patients'medical records. The collected data were analyzed using SPSS 18. Results: AIT was found in 13% of patients (8% female and 5% male). Significant levels were found for Anti-TPO (3%), anti-Tg (2%), and both antibodies (8%) in patients with AIT. Thyroid dysfunction was observed in 8 of 13 patients with AIT versus 2 of 87 patients without AIT (P<0.001). AIT was seen in 9% of diabetic children who had diabetes for less than one year versus 4% of the rest of diabetic children with duration more than one year (p<0 .0001). Conclusion: Because the majority of diabetic children with significant titers of antibodies developed thyroid disease, so thyroid function tests are necessary to reduce the risk of undiagnosed hypothyroidism in these patients

Treatment of large cutaneous facial hemangioma with ropranolol in a child with biliary atresia and esophageal varices

Introduction: Biliary atresia (BA) is the most common cause of neonatal jaundice, for which surgery is indicated. It may lead to portal hypertension and esophageal varices. Sometimes, BA is related to other congenital anomalies and malformation, while a coexistence of BA with facial hemangioma has not been reported, yet. Infantile hemangioma is a childhood benign vascular tumor. Beta blocker has an effect on hemangioma and esophageal varices. Case Report: A 30-day-old girl with an infantile hemangioma was referred to Amirkola Children's Hospital. According to intraoperative cholangiography and liver biopsy information, BA was diagnosed. Also, she had a large infantile cutaneous hemangioma on her face. Portal hypertension and esophageal varices were diagnosed in her under observation. So, propranolol was prescribed for her. A year after that, her facial hemangioma was gradually getting better. Conclusions: association of BA with infantile cutaneous hemangioma is rare and cutaneous hemangioma can be treated by propranolol

Detecting Common CFTR Mutations by Reverse Dot Blot Hybridization Method in Cystic Fibrosis; First Report from Northern Iran

Objective: Cystic fibrosis and its distribution vary widely in different countries and/or ethnic groups. Common CFTR mutations were reported from Iran, but the northern population was not or underrepresented in those studies. The aim of this study was to determine the frequency of common CFTR mutations in children from northern Iran. Methods: Thirty unrelated Iranian cystic fibrosis patients aged less than 11 years and living in Mazandaran province were screened for 5 common CFTR gene mutations. deltaF508, N1303K, G542X, R347H and W1282X using Reverse Dot Blot method. Findings: Only one mutation, DeltaF508, was found in 7 patients accounting for 21.7% (13/60) of alleles. Conclusion: These findings can be used for planning future screening and appropriate genetic counseling programs in Iranian CF families

Common CFTR gene mutations in cystic fibrosis patients in Mazandaran province - Iran

Background and Objective: Cystic fibrosis (CF) is the most common inherited disorder in Caucasian populations caused by mutation in cystic fibrosis transmembrane conductance regulator (CFTR). The type of mutations and their distributions varies widely between different countries and/or ethnic groups. The aim of this study was to characterize mutations involved in this disease in Mazandaran province, Iran. Materials and Methods: In this descriptive study thirty unrelated Iranian cystic fibrosis patients were screened for deltaF508, N1303K, G542X, R347H and W1282X mutations in the CFTR gene using Reverse Dot Blot method during 2004-06. This technique uses biotinilated PCR products for simultaneous hybridization with several normal and mutant probes specific to known mutations fixed on Biodyne C membranes. Results: DeltaF508 mutation was found in 13 (21.66%) alleles. 6 patients were homozygote and one was compound heterozygote for this mutation. Conclusion: These findings reveal an important heterogeneity of CFTR gene mutations in Mazandaran Province. Thus regarding the relative low rate of detectable mutations, it is necessary to undertake larger studies for molecular diagnosis of cystic fibrosis in this province

معرفی مفردات دارویی مؤثر در درمان «یبوست» در طب سنتی ایرانی

Constipation is one of the most common side effects of new life style. The use of traditional experience increases the chance to discover new effective medicinal materia and reduce the cost of new drug discovery. Many drugs have now herbal origin. There is no effective and low complication drug for constipation. But, there are so many medicinal materia in Persian Traditional Medicine references that can be used for treatment of constipation that we want to introduce them. This study is a library based and literature review research that&nbsp; investigates 6 traditional medicine pharmacology reference book (Al-Abnieh, Avicena Canon of medicine, Jamee Ibn-e-Beytar, Tazkere David Antaky, Tohfeh Hakim Momen, Makhzan-al- Advieh) about effectiveness of natural medicinal materia in the treatment of constipation. This work was performed in 9 steps including finding keywords, searching the resources, preparation of a unique list, eliminating synonyms, categorizing, reviewing, aggregation, exclusion of materia medica in combined products, scoring, and sorting them according to obtained scores. 134 proposed natural materials for treatment of constipation were found. Four important materia medica with laxative effect, were on the top of the list with the score of 11 (Prunus domestica, ficus cariaca, Cassia fistula, Cucurbita maxima (.120 medicinal materia are from herbal origin and the rest of them are from organic or mineral sources. This list of medicinal materia can be used as a base for clinical experiments to find new effective drugs for constipation treatment.«یبوست» یکی از شایع‌ترین عوارض سبک جدید زندگی است. استفاده از تجارب سنتی، احتمال کشف مواد مؤثر دارویی را افزایش می‌دهد و باعث کاهش هزینه ساخت داروها می‌شود. بسیاری از داروهای کنونی منشأ گیاهی دارند. هم اکنون درمان مؤثر وکم ضرری برای یبوست وجود ندارد. مفردات دارویی بسیاری در کتب طب سنتی ایرانی برای درمان یبوست وجود دارند که در این مطالعه معرفی می شوند. این تحقیق، یک مطالعه کتابخانه‌ای و براساس بررسی متون است. در این مطالعه مفردات دارویی مؤثر در درمان یبوست، در شش کتاب مرجع داروشناسی طب سنتی (الأبنیه عن حقایق الأدویه، قانون في الطب، جامع ابن بیطار ، تذکره داوود انطاکی، تحفه حکیم مؤمن و مخزن الأدویه) جستجو شد. این کار در 10 مرحله (یافتن کلیدواژه‌ها، جستجو در منابع، تهیه لیست واحد، یافتن مترادفات، دسته‌بندی، بازبینی، خروج مفردات از ترکیبات، جمع‌بندی و نمره‌دهی و مرتب‌سازی برحسب نمره کسب شده) انجام و 134 مفرده دارویی (تک دارو) مطرح در درمان یبوست یافت شد. به ترتیب نمره کسب شده، در بالای جدول برای 4 مفرده مهم در درمان یبوست (آلو، انجیر، خیارشنبر، کدو) بیشترین نمره (11) به دست آمد.120 مفرده از منشأ گیاهی و بقیه از منشأ حیوانی یا معدنی هستند. لیست مفردات دارویی حاصل شده در این مطالعه می تواند مبنای انجام مطالعات بالینی برای ساخت داروهای جدید مؤثر در درمان یبوست قرار گیرد