Stevia Rebaudiana Bertoni (Honey Leaf): A Magnificent Natural Bio-sweetener, Biochemical Composition, Nutritional and Therapeutic Values

Stevia rebaudiana Bertoni (Bert.) is a nutrient rich natural alternative to artificial sweetener, belongs to Asteraceae family and contains over hundred phytochemicals. The most important components of S. rebaudiana is steviol glycosides, and that thanks to its high potency sweetening which estimated about 300 times sweeter than saccharose but besides this has no calorific value. Many research activities on its biochemical and biological properties have been done in recent past. Accordingly, stevia has numerous therapeutic values in the treatment of patients with diabet-related obesity, hypertension or cardiac disease, antioxidant, antimicrobial and antifungal activity, for which sweetening properties have been identified. The aim of this review is to present biochemical composition, nutritional value and application of stevia leaves and its beneficial value to health. Keywords: Stevia rebaudiana, Asteraceae, biochemical, biological  properties, sweetener, nutritional

Chemical diversity of essential oil of the Moroccan endemic Origanum grosii in natural populations and after transplantation

International audienc

Influence of Environmental Factors on Essential Oil Variability in Origanum compactum Benth . Growing Wild in Morocco

International audienc

Natural Bioactive Compounds Targeting Epigenetic Pathways in Cancer: A Review on Alkaloids, Terpenoids, Quinones, and Isothiocyanates

Cancer is one of the most complex and systemic diseases affecting the health of mankind, causing major deaths with a significant increase. This pathology is caused by several risk factors, of which genetic disturbances constitute the major elements, which not only initiate tumor transformation but also epigenetic disturbances which are linked to it and which can induce transcriptional instability. Indeed, the involvement of epigenetic disturbances in cancer has been the subject of correlations today, in addition to the use of drugs that operate specifically on different epigenetic pathways. Natural molecules, especially those isolated from medicinal plants, have shown anticancer effects linked to mechanisms of action. The objective of this review is to explore the anticancer effects of alkaloids, terpenoids, quinones, and isothiocyanates

Pharmacological properties of trichostatin A, focusing on the anticancer potential:A comprehensive review

Trichostatin A (TSA), a natural derivative of dienohydroxamic acid derived from a fungal metabolite, exhibits various biological activities. It exerts antidiabetic activity and reverses high glucose levels caused by the downregulation of brain-derived neurotrophic factor (BDNF) expression in Schwann cells, anti-inflammatory activity by suppressing the expression of various cytokines, and significant antioxidant activity by suppressing oxidative stress through multiple mechanisms. Most importantly, TSA exhibits potent inhibitory activity against different types of cancer through different pathways. The anticancer activity of TSA appeared in many in vitro and in vivo investigations that involved various cell lines and animal models. Indeed, TSA exhibits anticancer properties alone or in combination with other drugs used in chemotherapy. It induces sensitivity of some human cancers toward chemotherapeutical drugs. TSA also exhibits its action on epigenetic modulators involved in cell transformation, and therefore it is considered an epidrug candidate for cancer therapy. Accordingly, this work presents a comprehensive review of the most recent developments in utilizing this natural compound for the prevention, management, and treatment of various diseases, including cancer, along with the multiple mechanisms of action. In addition, this review summarizes the most recent and relevant literature that deals with the use of TSA as a therapeutic agent against various diseases, emphasizing its anticancer potential and the anticancer molecular mechanisms. Moreover, TSA has not been involved in toxicological effects on normal cells. Furthermore, this work highlights the potential utilization of TSA as a complementary or alternative medicine for preventing and treating cancer, alone or in combination with other anticancer drugs