A hybrid approach based on personality traits for hate speech detection in Arabic social media

In recent years, as social media has grown in popularity, people have gained the ability to freely share their views. However, this may lead to users' conflict and hostility, resulting in unattractive online environments. Hate speech relates to using expressions or phrases that are violent, offensive, or insulting to a minority of people. The number of Arab social media users is quickly rising, and this is being followed by an increase in the frequency of cyber hate speech in the area. Therefore, the automated detection of Arabic hate speech has become a major concern for many stakeholders. The intersection of personality learning and hate speech detection is a relatively less studied niche. We suggest a novel approach that is focused on extracting personality trait features and using these features to detect Arabic hate speech. The experimental results show that the proposed approach is superior in terms of the macro-F1 score by achieving 82.3% compared to previous work reported in the literature

Influence of the Flexible Liposomes on the Skin Deposition of a Hydrophilic Model Drug, Carboxyfluorescein: Dependency on Their Composition

This study focuses on the effect of different flexible liposomes containing sodium cholate, Tween 80, or cineol on skin deposition of carboxyfluorescein (CF). Size distribution, morphology, zeta potential, and stability of the prepared vesicles were evaluated. The influence of these systems on the skin deposition of CF utilizing rat skin as membrane model was investigated. Results showed that all of the investigated liposomes had almost spherical shapes with low polydispersity (PDI < 0.3) and particles size range from 83 to 175 nm. All liposomal formulations exhibited negative zeta potential, good drug entrapment efficiency, and stability. In vitro skin deposition data showed that flexible liposomes gave significant deposition of CF on the skin compared to conventional liposomes and drug solutions. This study revealed that flexible liposomes, containing cineole, were able to deliver higher amount of CF suggesting that the hydrophilic drugs delivery to the skin was strictly correlated to the vesicle composition

Exploring Muslim mental health research on excess mortality in the context of stigmatized populations

Researchers have found a connection between mental health diagnoses and poorer health outcomes, causing an excess morbidity and mortality gap in these populations. These mentally ill individuals have the same somatic illnesses that afflict the general population, but they experience them at higher rates. Mentally ill minority populations are at even higher risk because underprivileged status on its own has been found to correlate with poorer health outcomes. Stigma and mental illness are compounding features of poorer health outcomes. The aim of this study was to highlight how addressing stigma in underprivileged populations may result in more health care utilization and treatment and better overall health outcomes for these at-risk patient groups

Erythrocyte nanovesicles: Biogenesis, biological roles and therapeutic approach Erythrocyte nanovesicles

AbstractNanovesicles (NVs) represent a novel transporter for cell signals to modify functions of target cells. Therefore, NVs play many roles in both physiological and pathological processes. This report highlights biogenesis, composition and biological roles of erythrocytes derived nanovesicles (EDNVs). Furthermore, we address utilization of EDNVs as novel drug delivery cargo as well as therapeutic target. EDNVs are lipid bilayer vesicles rich in phospholipids, proteins, lipid raft, and hemoglobin. In vivo EDNVs biogenesis is triggered by an increase of intracellular calcium levels, ATP depletion and under effect of oxidative stress conditions. However, in vitro production of EDNVs can be achieved via hypotonic treatment and extrusion of erythrocyte. NVs can be used as biomarkers for diagnosis, monitoring of therapy and drug delivery system. Many therapeutic agents are suggested to decrease NVs biogenesis

Assessment of oral hygiene trends among dental patients in relation to chronic medical conditions by dental students. A cross-sectional study

There is a lack of information about knowledge, attitude and behavior regarding oral hygiene and dietary habits of adult patients attending dental clinical settings. Hypertension, diabetes, obesity and caries are increasing among different populations, resulting in the deterioration of the quality of life related to oral and general health. Objectives: To involve second year dental students in assessing oral health knowledge, attitude, behavior, dietary habits and general health of dental patients, and screening for blood pressure, blood glucose level and obesity.Participants and methods: A convenient sample of 652 adult subjects participated in the study. They were screened, and involved in an interviewer- led questionnaire, led by the students  over the period of two successive academic years (2013- 2014) and  (2014- 2015).Results:  Subjects with high blood pressure and /or blood glucose levels were more likely to disagree regarding the presence of a relation between general health and dental health  [(r = -0.159, P-value &lt;0.001) (r = -0.257, P-value &lt;0.001) respectively]. Subjects with high BMI were less aware of the importance of using the tooth brush in prevention of gingival inflammation. The overall students’ satisfaction score was 71.5%. The practical part of the research had the highest satisfaction score (83.7%).Conclusions: There is scarcity of data regarding dental healthcare knowledge and attitudes in dental clinical settings. Additional clinical training for dental students would increase their willingness to play a preventive and educational role in the oral care of patients

Influence of pravastatin chitosan nanoparticles on erythrocytes cholesterol and redox homeostasis: An in vitro study

AbstractThe objective of this study was to develop and characterize chitosan nanoparticles (CSNPs) to increase efficacy of pravastatin (PR) on erythrocytes redox status. CSNPs and PR loaded CSNPs (PRCSNPs) were prepared by ionic gelation method. The particle size, zeta potential, scanning electron microscopy (SEM), differential scanning calorimetry (DSC), Fourier-transform infrared (FTIR) and X-ray diffraction (XRD) were used to investigate physicochemical characters of the prepared nanoparticles. The present results revealed that CSNPs and PRCSNPs have nanosize about 90nm with spherical shape, positive zeta potential and prolonged PR release. Moreover, DSC and FTIR indicated no chemical interactions between PR and CS. In vitro studies revealed that, erythrocyte uptake of PR from PRCSNPs was higher than free PR solution. Incubation of erythrocytes in high cholesterol plasma, hypercholesterolemia (HC), increases membrane cholesterol, erythrocyte hemolysis, oxidized glutathione (GSH), protein carbonyl (PCC), and malondialdeyhe (MDA). However, HC significantly decreases PR uptake by erythrocytes, superoxide dismutase (SOD), glutathione peroxidase (GPx) catalase (CAT) activities, reduced GSH and nitrite levels compared to control. By contrast, treatment of HC with PR plus CS as free drug or nanostructure formula keeps the measured parameters at values near that of control. The effect of CSNPs and PRCSNPs on redox status of erythrocytes was more prominent than free drugs. In conclusion, PRCSNPs are promising drug carrier to deliver PR into erythrocytes, moreover, PRCSNPs possess promising characteristics with high biological safety for treatment of HC induced disruption of redox homeostasis

Physical pegylation enhances the cytotoxicity of 5-fluorouracil-loaded PLGA And PCL nanoparticles.

Purpose : The main goal of this study is to evaluate the impact of physical incorporation of polyethylene glycol (PEG) into 5-fluorouracil (5-FU)-loaded polymeric nanoparticles (NPs). METHODS: The 5-FU-loaded NPs were prepared utilizing a simple double emulsion method using polycaprolactone (PCL) and polylactic-co-glycolic acid (PLGA) with or without PEG 6000. The surface charge, particle size, and shape of NPs were evaluated by standard procedures. Both Fourier Transform Infrared Spectroscopy and X-ray diffraction spectra of the 5-FU loaded NPs were compared against the pure 5-FU. The in vitro release profile of 5-FU from the NPs was monitored by the dialysis tubing method. Cell death and apoptosis induction in response to 5-FU NP exposure were measured by MTT and Annexin-V/7-amino-actinomycin D (7-AAD) assays, respectively, in Daoy, HepG2, and HT-29 cancer cell lines. RESULTS: The 5-FU loaded NPs were found to be spherical in shape with size ranging between 176±6.7 and 253.9±8.6 nm. The zeta potential varied between -7.13± 0.13 and -27.06±3.18 mV, and the entrapment efficiency was between 31.96% and 74.09%. The in vitro release of the drug followed a two-phase mode characterized by rapid release in the first 8 hrs followed by a period of slow release up to 72 hrs with composition-based variable extents. Cells exposed to NPs demonstrated a significant cell death which correlated with the ratio of PEG in the formulations in Daoy and HepG2 cells but not in HT-29 cells. Formulations (F1-F3) significantly induced early apoptosis in HT-29 cell lines. CONCLUSION: The physical PEGylation significantly enhanced the entrapment and loading efficiencies of 5-FU into NPs formulated with PLGA and PCL. It also fostered the in vitro cytotoxicity of 5-FU-loaded NPs in both Daoy and HepG2 cells. Induction of early apoptosis was confirmed for some of the formulations

Novel docetaxel chitosan-coated PLGA/PCL nanoparticles with magnified cytotoxicity and bioavailability

In the present study, docetaxel (DTX)-loaded poly(lactic-co-glycolic acid) (PLGA) and polycaprolactone (PCL) nanoparticles were successfully prepared and coated with chitosan (CS). The prepared nanoparticles (NPs) were evaluated for their particle size, zeta potential, particle morphology, drug entrapment efficiency (EE%), and in vitro drug release profile. The anticancer activity of DTX-loaded NPs was assessed in human HT29 colon cancer cell line utilizing MTT assay. The pharmacokinetics of DTX-loaded NPs was monitored in Wistar rats in comparison to DTX solution. The prepared NPs exhibited particle sizes in the range 177.1 ± 8.2-287.6 ± 14.3 nm. CS decorated NPs exhibited a significant increase in particle size and a switch of zeta potential from negative to positive. In addition, high EE% values were obtained for CS coated PCL NPs and PLGA NPs as 67.1 and 76.2%, respectively. Moreover, lowering the rate of DTX in vitro release was achieved within 48 h by using CS coated NPs. Furthermore, a tremendous increase in DTX cytotoxicity was observed by CS-decorated PLGA NPs compared to all other NPs including DTX-free-NPs and pure DTX. The in vivo study revealed significant enhancement in DTX bioavailability from CS-decorated PLGA NPs with more than 4-fold increase in AUC compared to DTX solution. In conclusion, CS-decorated PLGA NPs are a considerable DTX-delivery carrier with magnificent antitumor efficacy

Assessment of the Extent of Myocardial Injury in Patients Undergoing Transvenous Implantation of a Pacemaker Using Cardiac Troponin I as a Marker of Structural Heart Damage and Its Relation to Different Sites of RV Implantation

Background and Aim: This study aimed to evaluate the degree of myocardial injury that occurs after transvenous pacemaker implantation using cardiac troponin I (cTnI) as a myocardial injury marker and the relationship between the number of screws, different sites of right ventricle (RV) lead implantation, and myocardial injury. Materials and Methods: Fifty patients at Ain Shams University Hospitals who underwent transvenous implantation of single- or dual-chamber permanent pacemakers were included in the study. According to the site of RV lead implantation, the study population was divided into 2 equal groups, 25 patients each. In the first group, the RV lead was implanted in the RV apex and in the other group, the RV lead was implanted in the RV septum. Results: In all patients, the cTnI level was elevated after pacemaker implantation, showing a significant relationship between transvenous pacemaker implantation and the incidence of myocardial injury. Comparing the RV apical pacing group with the RV septal pacing group, a greater rise in cTnI was recognized in the septal RV pacing group, indicating a significant relationship between the site of RV lead implantation and the degree of myocardial injury being more in the RV septum than in the RV apex. Moreover, the higher the number of attempts of screwing the lead in different RV sites caused more rise in cTnI, denoting a significant relationship between the number of screwing attempts and the extent of myocardial injury. Conclusion: Transvenous pacemaker implantation is associated with an increased incidence of myocardial injury, and septal RV lead implantation is associated with a higher degree of myocardial injury than apical RV lead implantation. In addition, a higher number of screwing attempts of the RV lead into the myocardium is associated with a higher degree of myocardial injury