Synthesis of indolo[2',3':5,6][1,2,4]triazino[4,3-a][1,8]- naphthyridines and 3'-(3-phenyl-1,8-naphthyridin-2-ylamino)spiro- [3H-3,2' -thiazolidine]- 2,4'(1H)-diones as potential antibacterial agents

894-89

Studies in spiroheterocycles: Part II–Synthesis and antibacterial activity of some novel spiro[indole-pyrazolines], spiro[indole-pyrimidines] and spiro[indole-1,5-benzodiazepines] containing 1,8-naphthyridine moiety

139-14

Al₂O₃ catalyzed Friedlander synthesis of 1, 8-naphthyridines in the solid state

1721-1723Al₂O₃ catalyzes efficiently the Freidlander condensation of 2-aminonicotinaldehyde 1 with various carbonyl compounds containing ⍺-methylene group 2 in the solid state to afford the corresponding 1,8-naphthyridines 3. The reaction proceeds efficiently at room temperature in good yields and in a state of high purity

Synthesis and antibacterial activity of 1,3,4-oxadiazolyl-1,8-naphthyridines

1905-1908Condensation of (2-oxo-3-phenyl-2H-[1,8]naphthyridin-1-yl)-acetic acid hydrazide 2 with different acetophenones yields the corresponding acetophenone (2-oxo-3-phenyl-2H-[1,8]naphthyridin-1-yl)methylcarbonyl hydrazones 3, which on treatment with acetic anhydride affords the respective 1-(4-acetyl-5-aryl-5-methyl-[1,3,4]oxadiazol-2-ylmethyl)-3-phenyl-1H-[1,8]naphthyridin-2-ones 4. The structures of the compounds 3 and 4 have been confirmed on the basis of analytical and spectral data. The compounds 4 have been screened for their antibacterial activity

Synthesis of some novel bridgehead nitrogen heterocyclic systems containing 1,8 naphthyridine moiety

192-1943-Aryl-2-chloro- I,8-naphthyridines 3 on treatment with anthranilic acids, o-phenylenediamine and sodium azide afford quinazolino[3 ,2-a][1,8]naphthyridin-13-ones 4, benzimidazo[1,2-a] [1,8]naphthyridines 5 and tetrazolo[1,5-a][1,8] naphthyridines 6, respectively. The structures of compounds 4-6 have been established by IR, 1H NMR and mass spectral data. The compounds 4 have been evaluated for their antibacterial activity

Hypervalent iodine mediated solid state synthesis of 1,8-naphthyridinyl-1,3,4- oxadiazoles

619-6212-Trifluoromcthyl-1,8-naphthyridine-3-carboxylic acid arylidene-hydrazides (acylhydrazones) 2 can be conveniently converted to the corresponding 5-aryl-2-(2-trifluoromethyl -1,8-naphthyridin-3-yl)-1,3,4-oxadiazoles 3 with iodobenzene diacetate (IBD) under solid state conditions. The reaction proceeds efficiently giving the products in excellent yields at ambient temperature

Efficient synthesis of 1,2,4-triazolo[4,3-<i>a</i>][1,8]naphthyridines using nitrous acid under microwave irradiation

2641-2645A highly efficient, simple and rapid method for the synthesis of 1,2,4-triazolo[4,3-a][1,8] naphthyridines 8 by the oxidation of the corresponding aryl aldehyde 3-(p-nitrophenyl)-1, 8-naphthyridin-2-ylhydrazones 7 using nitrous acid (NaNO2/CH3COOH) under microwave irradiation has been described. Microwave assisted react ions have resulted in better yields or the desired products than prepared under conventional conditions. The structures of the compounds 3-8 are supported by spectral and analytical data