4 research outputs found
Chromosomal abnormalities as a cause of recurrent abortions in Egypt
Background: In 4%-8% of couples with recurrent abortion, at least one
of the partners has chromosomal abnormality. Most spontaneous
miscarriages which happen in the first and second trimesters are caused
by chromosomal abnormalities. These chromosomal abnormalities may be
either numerical or structural. Material and Methods : Cytogenetic
study was done for 73 Egyptian couples who presented with recurrent
abortion at Genetic Unit of Children Hospital, Mansoura University.
Results : We found that the frequency of chromosomal abnormalities was
not significantly different from that reported worldwide. Chromosomal
abnormalities were detected in 9 (6.1%) of 73 couples. Seven of
chromosomal abnormalities were structural and two of them were
numerical. Conclusion : Our results showed that 6.1% of the couples
with recurrent abortion had chromosomal abnormalities, with no other
abnormalities. We suggest that it is necessary to perform cytogenetic
in vestigation for couples who have recurrent abortion
Chromosomal abnormalities as a cause of recurrent abortions in Egypt
Background: In 4%-8% of couples with recurrent abortion, at least one
of the partners has chromosomal abnormality. Most spontaneous
miscarriages which happen in the first and second trimesters are caused
by chromosomal abnormalities. These chromosomal abnormalities may be
either numerical or structural. Material and Methods : Cytogenetic
study was done for 73 Egyptian couples who presented with recurrent
abortion at Genetic Unit of Children Hospital, Mansoura University.
Results : We found that the frequency of chromosomal abnormalities was
not significantly different from that reported worldwide. Chromosomal
abnormalities were detected in 9 (6.1%) of 73 couples. Seven of
chromosomal abnormalities were structural and two of them were
numerical. Conclusion : Our results showed that 6.1% of the couples
with recurrent abortion had chromosomal abnormalities, with no other
abnormalities. We suggest that it is necessary to perform cytogenetic
in vestigation for couples who have recurrent abortion
Cytoprotective effect of honey against chromosomal breakage in fanconi anemia patients in vitro
Background : Natural honey is widely used all over the world as a
complementary and alternative medicine in various disorders including
Fanconi anemia (FA). FA is a rare genetic chromosomal instability
syndrome caused by impairment of DNA repair and reactive oxygen species
(ROS) imbalance. This disease is also related to bone marrow failure
and cancer. The aim of this study was to evaluate the cytoprotective
effect of honey on mitomycin C (MMC-) induced chromosomal damage in
peripheral lymphocytes from FA patients. Materials and Methods
:Treatment of these complications with alkylation agents MMC may
enhance chromosomal breakage. We have evaluated the effect of honey on
MMC- induced chromosomal breakage in FA blood cells using chromosomal
breakage assay. The basal chromosomal breakage count was higher among
FA patients than healthy subjects. Results : The addition of MMC alone
gave a significantly higher of chromosomal breakage in FA patients than
control group (P < 0.0001). Pre- treatment with honey significantly
inhibited breakage induced by MMC in FA patients by its antioxidant
effect. Conclusion : Honey can prevent MMC- induced chromosomal
breakage by its antioxidant effect
Cytoprotective effect of honey against chromosomal breakage in fanconi anemia patients in vitro
Background : Natural honey is widely used all over the world as a complementary and alternative medicine in various disorders including Fanconi anemia (FA). FA is a rare genetic chromosomal instability syndrome caused by impairment of DNA repair and reactive oxygen species (ROS) imbalance. This disease is also related to bone marrow failure and cancer. The aim of this study was to evaluate the cytoprotective effect of honey on mitomycin C (MMC-) induced chromosomal damage in peripheral lymphocytes from FA patients.
Materials and Methods :Treatment of these complications with alkylation agents MMC may enhance chromosomal breakage. We have evaluated the effect of honey on MMC- induced chromosomal breakage in FA blood cells using chromosomal breakage assay. The basal chromosomal breakage count was higher among FA patients than healthy subjects.
Results : The addition of MMC alone gave a significantly higher of chromosomal breakage in FA patients than control group (P < 0.0001). Pre- treatment with honey significantly inhibited breakage induced by MMC in FA patients by its antioxidant effect.
Conclusion : Honey can prevent MMC- induced chromosomal breakage by its antioxidant effect