Background: In 4%-8% of couples with recurrent abortion, at least one
of the partners has chromosomal abnormality. Most spontaneous
miscarriages which happen in the first and second trimesters are caused
by chromosomal abnormalities. These chromosomal abnormalities may be
either numerical or structural. Material and Methods : Cytogenetic
study was done for 73 Egyptian couples who presented with recurrent
abortion at Genetic Unit of Children Hospital, Mansoura University.
Results : We found that the frequency of chromosomal abnormalities was
not significantly different from that reported worldwide. Chromosomal
abnormalities were detected in 9 (6.1%) of 73 couples. Seven of
chromosomal abnormalities were structural and two of them were
numerical. Conclusion : Our results showed that 6.1% of the couples
with recurrent abortion had chromosomal abnormalities, with no other
abnormalities. We suggest that it is necessary to perform cytogenetic
in vestigation for couples who have recurrent abortion