A report about a rare case of tail gut cyst (TGC) in a 90-year-old man with sacrum ulceration

مقدمه: تیلگات کیست (Tailgut cyst=TGC) یک ضایعه کیستیک غیر شایع با منشا بقایای رودهPostnatal است که در فضای خلف رکتوم ایجاد می گردد. گزارش مورد: آقای 90 ساله اهل میناب با شکایت زخم در ناحیه ساکروم در مرکز آموزشی درمانی شهید صدوقی یزد پذیرش شد. بیمار در گرفتن شرح حال همکاری لازم را نداشت. بعد از انجام آزمایشات معمول، بیمار تحت عمل جراحی قرار گرفت و ناحیه مربوطه از نظر ترشحات تخلیه و ترمیم شد و طی عمل جراحی به توده ای در ناحیه ساکروم برخورد گردید، بعد از برش کامل و خارج کردن آن در بررسی آسیب شناسیTGC تشخیص داده شد. نتیجه گیری: با اینکه بروز بدخیمی در تیلگات کیست نادر است ولی باید در تشخیص افتراقی، تمام تومورهای خلف رکتوم به ویژه در زنان میانسال مورد توجه قرار گیرد

Selenium-capped cyclic peptide nanoparticles for penicillamine drug delivery: A DFT Study

43-50Using a model for performance of penicillamine (PCA) anti-cancer drug on selenium-cyclic peptide nanoparticle (CPSeNP), 11 noncovalent configurations have been investigated. Se8 ring model and cyclooctaglycine have been used for selenium nanoparticle (SeNP) and cyclic peptide (CP), respectively. Binding energies, quantum molecular descriptors and solvation energies have been studied in gas phase and water at M06-2X /6-31G** level of theory. The calculated energies represent the high-energy stability of CPSeNP/PCA 1-11 configurations. Solvation energies showed that drug solubility increases, which is a major factor for their use in drug delivery. Regarding to quantum molecular descriptors such as hardness and electrophilic power, the drug reactivity increases in the vicinity of SeNP. The QTAIM analysis revealed that intramolecular interaction Se-L (L =O, H , S, C , N) plays an important role in the system. Se-L interaction in all configurations is relevant to weak interactions. The configurations that PCA drug is located in parallel with the carrier (CPSeNP) are more stable than penicillamine-CP or penicillamine-SeNP systems

Corneal endothelial cell density and morphology in normal Iranian eyes

BACKGROUND: We describe corneal endothelial cell density and morphology in normal Iranian eyes and compare endothelial cell characteristics in the Iranian population with data available in the literature for American and Indian populations. METHODS: Specular microscopy was performed in 525 eyes of normal Iranian people aged 20 to 85 years old. The studied parameters including mean endothelial cell density (MCD), mean cell area (MCA) and coefficient of variation (CV) in cell area were analyzed in all of the 525 eyes. RESULTS: MCD was 1961 ± 457 cell/mm(2 )and MCA was 537.0 ± 137.4 μm(2). There was no statistically significant difference in MCD, MCA and CV between genders (Student t-test, P = 0.85, P = 0.97 and P = 0.15 respectively). There was a statistically significant decrease in MCD with age (P < 0.001, r = -0.64). The rate of cell loss was 0.6% per year. There was also a statistically significant increase in MCA (P < 0.001,r = 0.56) and CV (P < 0.001, r = 0.30) from 20 to 85 years of age. CONCLUSION: The first normative data for the endothelium of Iranian eyes seems to confirm that there are no differences in MCD, MCA and CV between genders. Nevertheless, the values obtained in Iranian eyes seem to be different to those reported by the literature in Indian and American populations

Guanidinium (aqua-2κO)(4-hydr­oxy-6-carboxy­pyridine-2-carboxyl­ato-2κ3 O 2,N,O 6)(μ-4-hydroxy­pyridine-2,6-dicarboxyl­ato-1:2κ4 O 2,N,O 6:O 2)(4-hydroxy­pyridine-2,6-dicarboxyl­ato-1κ3 O 2,N,O 6)dizincate(II) dihydrate

The title compound, (CH6N3)[Zn2(C7H3NO5)2(C7H4NO5)(H2O)]·2H2O, has an anionic binuclear complex of ZnII balanced with a guanidinium cation. There are two uncoord­inated water mol­ecules in the structure. The asymmetric unit of the compound has two different coordination types (the coordination of Zn1 is distorted trigonal-bipyramidal, while that of Zn2 is distorted octahedral) of ZnII in the crystal structure that are bridged to each other via one hypydc2− group (hypydcH2 is 4-hydroxy­pyridine-2,6-dicarboxylic acid). A variety of inter­molecular O—H⋯O, N—H⋯O and C—H⋯O hydrogen bonds involving water mol­ecules, cations and anions, and also a weak π–π inter­action [3.798 (1) Å], are responsible for extending the structure into a three-dimensional network

Hydroxonium creatininium bis­(pyridine-2,6-dicarboxyl­ato-κ3 O 2,N,O 6)cobaltate(II) trihydrate

The title compound, (C4H8N3O)(H3O)[Co(C7H3NO4)2]·3H2O, contains a protonated creatininium cation, a hydrox­onium (H3O)+ cation, a [Co(pydc)2]2− (pydcH2 = pyridine-2,6-dicarboxylic acid) complex anion, and three uncoordinated water mol­ecules. The CoII atom is coordinated by four O and two N atoms from two pydc ligands in a distorted octa­hedral environment. The structure also contains three uncoordinated water mol­ecules. Extensive inter­molecular O—H⋯O, N—H⋯O and C—H⋯O hydrogen bonds, π–π stacking inter­actions [centroid–centroid distances = 3.565 (14) and 3.425 (14) Å] and O⋯π inter­actions [O⋯centroid distance = 3.480 (2) Å] connect the various components in the crystal structure

Wind barriers optimization for minimizing collector mirror soiling in a parabolic trough collector plant

Wind barriers, according to their sizes and shapes, can effectively control, shift and even modify the airflow field in their downstream. These structures can accelerate the wind flow over the mirror field and move the airborne particles away from the mirrors. For example, in concentrated solar power plants it is highly desirable to engineer the system in a way that fewer particles are deposited within the solar field, in particular, onto mirror surfaces. Therefore, design optimization of dust barriers could significantly impact the mirror soiling and favourably reduce the cleaning water consumption of a solar power plant. This study focuses on the optimization of a solid wind barrier around a parabolic trough collector plant for their protection against dust soiling. The presented simulation results show that an optimum solid wind barrier is able to direct large amount of particles (in this study, more than 86%) to pass over the solar field with very small fraction (around 0.8%) being deposited on the mirrors. In addition, it was found that the barrier wall is more effective in deflecting the larger particles from the solar field.http://www.elsevier.com/locate/apenergy2019-09-01hj2018Mechanical and Aeronautical Engineerin