Fast Domain Growth through Density-Dependent Diffusion in a Driven Lattice Gas

We study electromigration in a driven diffusive lattice gas (DDLG) whose continuous Monte Carlo dynamics generate higher particle mobility in areas with lower particle density. At low vacancy concentrations and low temperatures, vacancy domains tend to be faceted: the external driving force causes large domains to move much more quickly than small ones, producing exponential domain growth. At higher vacancy concentrations and temperatures, even small domains have rough boundaries: velocity differences between domains are smaller, and modest simulation times produce an average domain length scale which roughly follows $L \sim t^{\zeta}$, where $\zeta$ varies from near .55 at 50% filling to near .75 at 70% filling. This growth is faster than the $t^{1/3}$ behavior of a standard conserved order parameter Ising model. Some runs may be approaching a scaling regime. At low fields and early times, fast growth is delayed until the characteristic domain size reaches a crossover length which follows $L_{cross} \propto E^{-\beta}$. Rough numerical estimates give $\beta= >.37$ and simple theoretical arguments give $\beta= 1/3$. Our conclusion that small driving forces can significantly enhance coarsening may be relevant to the YB$_2$Cu$_3$O$_{7- \delta}$ electromigration experiments of Moeckly {\it et al.}(Appl. Phys. Let., {\bf 64}, 1427 (1994)).Comment: 18 pages, RevTex3.

Effect of stoichiometry on oxygen incorporation in MgB2 thin films

The amount of oxygen incorporated into MgB2 thin films upon exposure to atmospheric gasses is found to depend strongly on the material's stoichiometry. Rutherford backscattering spectroscopy was used to monitor changes in oxygen incorporation resulting from exposure to: (a) ambient atmosphere, (b) humid atmospheres, (c) anneals in air and (d) anneals in oxygen. The study investigated thin-film samples with compositions that were systematically varied from Mg0.9B2 to Mg1.1B2. A significant surface oxygen contamination was observed in all of these films. The oxygen content in the bulk of the film, on the other hand, increased significantly only in Mg rich films and in films exposed to humid atmospheres.Comment: 10 pages, 6 figures, 1 tabl

Direct measurement of the magnetic penetration depth by magnetic force microscopy

We present an experimental approach using magnetic force microscopy for measurements of the absolute value of the magnetic penetration depth (lambda) in superconductors. Lambda is obtained in a simple and robust way without introducing any tip modeling procedure via direct comparison of the Meissner response curves for a material of interest to those measured on a reference sample. Using a well characterized Nb film as a reference, we determine the absolute value of lambda in a Ba(Fe0.92Co0.08)2As2 single crystal and a MgB2 thin film through a comparative experiment. Our apparatus features simultaneous loading of multiple samples, and allows straightforward measurement of the absolute value of lambda in superconducting thin film or single crystal samples.Fil: Kim, Jeehoon. No especifíca;Fil: Civale, L.. No especifíca;Fil: Nazaretski, E.. No especifíca;Fil: Haberkorn, Nestor Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; ArgentinaFil: Ronning, F.. No especifíca;Fil: Sefat, A. S.. No especifíca;Fil: Tajima, T.. No especifíca;Fil: Moeckly, B. H.. No especifíca;Fil: Thompson, J. D.. No especifíca;Fil: Movshovich, R.. No especifíca

Measurement of the magnetic penetration depth of a superconducting MgB2_{2} thin film with a large intraband diffusivity

We report the temperature dependent magnetic penetration depth $\lambda(T)$ and the superconducting critical field $H_{c2}(T)$ in a 500-nm MgB$_{2}$ film. Our analysis of the experimental results takes into account the two gap nature of the superconducting state and indicates larger intraband diffusivity in the three-dimensional (3D) $\pi$ band compared to that in the two-dimensional (2D) $\sigma$ band. Direct comparison of our results with those reported previously for single crystals indicates that larger intraband scattering in the 3D $\pi$ band leads to an increase of $\lambda$. We calculated $\lambda$ and the thermodynamic critical field $H_{c}\approx$2000 Oe employing the gap equations for two-band superconductors. Good agreement between the measured and calculated $\lambda$ value indicates the two independent measurements, such as magnetic force microscopy and transport, provide a venue for investigating superconducting properties in multi-band superconductors

A sol-gel method for growing superconducting MgB2 films

In this paper we report a new sol-gel method for the fabrication of MgB2 films. Polycrystalline MgB2 films were prepared by spin-coating a precursor solution of Mg(BH_4)_2 diethyl ether on (001)Al2O3 substrates followed with annealing in Mg vapor. In comparison with the MgB2 films grown by other techniques, our films show medium qualities including a superconducting transition temperature of Tc ~ 37 K, a critical current density of Jc(5 K, 0 T) ~ 5 {\times} 10^6 A cm^{-2}, and a critical field of H_{c2}(0) ~ 19 T. Such a sol-gel technique shows potential in the commercial fabrication of practically used MgB2 films as well as MgB2 wires and tapes.Comment: 8 pages, 5 figure

Influence of vortex-vortex interaction on critical currents across low-angle grain boundaries in YBa2Cu3O7-delta thin films

Low-angle grain boundaries with misorientation angles theta < 5 degrees in optimally doped thin films of YBCO are investigated by magnetooptical imaging. By using a numerical inversion scheme of Biot-Savart's law the critical current density across the grain boundary can be determined with a spatial resolution of about 5 micrometers. Detailed investigation of the spatially resolved flux density and current density data shows that the current density across the boundary varies with varying local flux density. Combining the corresponding flux and current pattern it is found that there exists a universal dependency of the grain boundary current on the local flux density. A change in the local flux density means a variation in the flux line-flux line distance. With this knowledge a model is developped that explains the flux-current relation by means of magnetic vortex-vortex interaction.Comment: 7 pages, 14 figure

Evidence for Irradiation Triggered Nonuniform Defect Distribution In Multiharmonic Magnetic Susceptibility of Neutron Irradiated YBa2Cu3O7-x

Multiharmonic ac-magnetic susceptibility \ch11,\chi2,chi3, of neutron irradiated Li-doped YBa2Cu3O7-x has revealed a nonmonotonic dependence of all harmonics on the neutron fluence. The irradiation has a strongly depressive influence on the intergrain connection suggesting an increase of the effective thickness of the intergranular Josephson junction at aneutron fluence of 0.98x10$^{17}$ cm$_{-2}$. Less damaged are the intragrain properties. A spectacular enhancement of the superconducting intragranular properties reflected in the characteristics of all harmonics was observed at highest fluence \Phi = 9.98x10$^{17}$ cm$_{-2}$. We assume that this effect results from the development of a space inhomogeneous distribution with alternating defectless and defect rich regions.Comment: 24 pages, 9 figures, accepted to J. Supercon

The Influence of Neutron Irradiation on (B0.65C0.35)Ba1.4Sr0.6Ca2Cu3Oz Superconducting Phase: the Role of the Grain Edge

Using the transport and magnetization measurements the influence of neutron irradiation at a fluence of 5x10$^{17}$ n cm$^{-2}$ on (B0.65C0.35)Ba1.4Sr0.6Ca2Cu3Oz has been investigated. The neutron irradiation was found to decrease critical temperature and transport critical current density, increase the residual and normal state resistivity, and improve the intragranular critical current density with 1.6x10$^{57}$ A/cm$^{2}$ (at 77.3K and in the applied field up to 160 kA m) and \Delta Mirr/\Delta Mnonirr ratio (up to factor of 3) at highest field used for investigation. The field dependence of this ratio, which is below the unity at very low field but higher than 1 at high fields, correlated with the shape of the hystertic loops as well as with the change of the transport parameters after irradiation suggests the role of the irradiation induced effects on the grain edges. We discuss these effects in the framework of the Bean-Livingstone surface barriers and geometrical barriers.Comment: 12 pages, 5 figure

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Evidence for non-s-wave symmetry of the π gap in MgB[subscript 2] from intermodulation distortion measurements

We present low-temperature low-power intermodulation-distortion (IMD) measurements of high-quality MgB[subscript 2] thin films that are inconsistent with presumed s-wave symmetry of the order parameter. The measurements were carried out in a stripline resonator at approximately 2 GHz between 1.8 K and T[subscript c]. The IMD arises from the nonlinear Meissner effect in which the penetration depth is dependent on the RF magnetic field. Specifically, the observed IMD vs temperature T for T≪T[subscript c]/2 varies as T[superscript −2], while for an s-wave gap symmetry in the clean limit, the low-temperature IMD decreases exponentially with decreasing temperature. We calculate the IMD from first principles for different order-parameter symmetries using a Green’s function approach and compare the results with the measured data. We propose that the observed upturn in the low-temperature IMD implies an admixture of an order parameter with nodal lines into the energy gaps of MgB[subscript 2]. Most likely, this admixture is prominent for the π gap. Within the constraints of the hexagonal crystal symmetry of MgB[subscript 2], the best fit with our IMD measurements is obtained with a gap Δ(ϕ,T)=Δ[subscript 0](T)sin(6ϕ), where ϕ is the azimuthal angle in the abˆ plane, and Δ[subscript 0](T) is the amplitude, weakly temperature dependent at low temperatures. This gap symmetry entails six nodal lines. We also present low-temperature penetration-depth measurements that are consistent with the proposed nodal gap symmetry. To relate our proposition with existing literature, we review other low-temperature probes of the order-parameter symmetry. The literature presents conflicting results, some of which are in direct support of the symmetry proposed here.United States Department of the Nav