Granulomatous mesenteric lymphadenitis after three doses of the COVID-19 vaccine

Lymphadenopathy related to vaccination has been reported as an adverse effect of mRNA-based COVID-19 vaccines. Most cases are regional lymph nodes near of injection site, with mild-moderate 18 F-fluorodeoxyglucose uptake on positron emission tomography. We report a middle-aged Brazilian man with mesenteric lymphadenitis manifested five days after the third dose of the Pfizer-BioNTech mRNA-based vaccine against COVID-19. The patient had no known risk factors and evolved with rapid clinical improvement. The imaging findings, laboratory determinations, histopathological and microbiological evaluations raised doubts about the hypothesis of an eventual adverse effect of the vaccine. The aim is to call attention to possible rare reactions of SARS-CoV-2 vaccinations

Infecção por Cryptococcus limitada à próstata em paciente aidético com micobacteriose disseminada. Relato de necropsia

Relata-se caso de infecção criptocócica confinada à próstata, como achado de necropsia, em homem de 32 anos portador da síndrome da imunodeficiência adquirida (SIDA) com micobacteriose disseminada. Enfatiza-se a importância do achado incidental em necropsia e a persistência dessa infecção micótica na próstata

HEADACHE IN CHAGASIC WOMEN Cefaléia em mulheres chagásicas

The aim of this study was to compare the frequency of headache between Chagasic and Non-chagasic women. The cross-sectional study comprised 647 female <FONT FACE="Symbol">³</font>40 years old, Chagasic (n = 362) and Controls (n = 285) at a Brazilian University Hospital. Chagasic were classified as Cardiac (n = 179), Megas (n = 58) or Indeterminate (n = 125) clinical forms. Headache was ascertained according to Headache International Society diagnostic criteria. The age (57.0 ± 11.3 versus 57.3 ± 10.4 years), and the percentage of white women (75.8% versus 77.1%) were similar between Chagasic and Controls, respectively. Headache was more prevalent among Chagasic (32.9%) than Controls (16.1%), mainly in Cardiac form (odds ratio, 2.41; 95% confidence interval, 1.38-4.23), phenomenon possibly related to parasympathetic denervation and cerebral vessels changes.<br>O propósito do estudo foi comparar a freqüência de cefaléia entre mulheres Chagásicas e Não-chagásicas. O estudo retrospectivo compreendeu 647 mulheres com idade <FONT FACE="Symbol">³</font> 40 anos, Chagásicas (n = 362) e Controles (n = 285) atendidas em um Hospital Universitário brasileiro. As Chagásicas foram classificadas nas formas clínicas: Cardíacas (n = 179), Megas (n = 58) e Indeterminada (n = 125). Cefaléia foi definida de acordo com os critérios da Headache International Society. A idade (57,0 ± 11,3 versus 57,3 ± 10,4 anos) e a percentagem de mulheres de cor branca (75,8% versus 77,1%) foram semelhantes entre Chagásicas e Controles, respectivamente. Cefaléia foi mais freqüente entre Chagásicas (32,9%) que nas Controles (16,1%), principalmente na forma Cardíaca (odds ratio, 2,41; intervalo de confiança 1,38-4,23), fenômeno possivelmente relacionado com desnervação parassimpática e alterações vasculares cerebrais