C. R. Mecanique 330 (2002) 557--562

Though a minor component by volume, platelets can have a profound influence on the flow characteristics of blood and thereby have serious consequences with regard to cardiovascular functions. Platelets are extremely sensitive to chemical agents as well as mechanical inputs and platelet activation is a necessary precursor to many life threatening medical conditions such as acute myocardial infarction, most strokes, acute arterial occlusion, venous thrombosis and pulmonary embolism. In cardiovascular devices such as ventricular assist devices and prosthetic heart valves, high shear stresses can trigger platelet activation. Moreover, such devices have artificial surfaces that are thrombogenic, the thrombotic deposition contributing to the failure of the device. Thus, there is a need to develop a mathematical model for the flow of blood that takes into account platelet activation, no such model being available at the moment. While there has been considerable amount of work in blood rheology, the role of platelets in the flow characteristics of blood has been largely ignored. This study addresses this lacuna. To cite this article: M. Anand, K.R. Rajagopal, C. R. Mecanique 330 (2002) 557--562. 2002 Acadmie des sciences/ditions scientifiques et mdicales Elsevier SAS rheology / platelet activation / shear thinning / viscoelasticity Un modle mathmatique dcrivant le changement du caractre constitutif du sang d l'activation des plaquettes Rsum Les plaquettes peuvent avoir une profonde influence sur les caractristiques de l'coulement sanguin, mme si elles ne forment qu'une faible composante du volume du sang. De ce fait, elles peuvent avoir des consquences graves sur le fonctionnement cardiovasculaire. Les plaquettes sont extrmement sensibles aux agents chimiques et aux effor..

Mathematical, theoretical and phenomenological challenges beyond the standard model : perspectives of the Balkan collaborations

xvii, 279 p. : ill. ; 24 cm

Vol. 2, No. 4, October-December 1996

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