769 research outputs found

    Metadata for the WAGES instrumentation deployed on the James Clark Ross between May 2010 and September 2011

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    The RRS James Clark Ross makes meteorological measurements around Antarctica during the austral summer, in the Arctic during the boreal summer and in the Atlantic during passages between the two poles. In May 2010, as part of the WAGES project the ships existing systems were complemented by the AutoFlux system (Yelland et al., 2009) to measure the transfers of momentum, heat and CO2 between the atmosphere and the ocean. Similarly, a commercial directional wave radar "WAVEX" made by the Norwegian firm MIROS was installed.This report describes the metadata for the WAGES instrumentation deployed on the RRS James Clark Ross between May 2010 and September 2011. Sensor serial numbers, dates of sensor changes andproblems with sensors are contained in the associated tables

    Metadata for the WAGES instrumentation deployed on the RRS James Clark Ross between May 2010 and September 2013

    No full text
    The RRS James Clark Ross makes meteorological measurements around Antarctica during the austral summer, in the Arctic during the boreal summer and in the Atlantic during passages between the two poles. In May 2010, as part of the WAGES project the ships existing systems were complemented by the AutoFlux system (Yelland et al., 2009) to measure the transfers of momentum, heat and CO2 between the atmosphere and the ocean. Similarly, a commercial directional wave radar "WAVEX" made by the Norwegian firm MIROS was installed. This report describes the metadata for the WAGES instrumentation deployed on the RRS James Clark Ross between May 2010 and September 2013. Sensor serial numbers, dates of sensor changes and problems with sensors are contained in the associated tables

    Metadata for the WAGES instrumentation deployed on the James Clark Ross between May 2010 and September 2011.

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    The RRS James Clark Ross makes meteorological measurements around Antarctica during the austral summer, in the Arctic during the boreal summer and in the Atlantic during passages between the two poles. In May 2010, as part of the WAGES project the ships existing systems were complemented by the AutoFlux system (Yelland et al., 2009) to measure the transfers of momentum, heat and CO2 between the atmosphere and the ocean. Similarly, a commercial directional wave radar "WAVEX" made by the Norwegian firm MIROS was installed. This report describes the metadata for the WAGES instrumentation deployed on the RRS James Clark Ross between May 2010 and September 2011. Sensor serial numbers, dates of sensor changes andproblems with sensors are contained in the associated tables

    Effect of Riboflavin Status on the Homocysteine-lowering Effect of Folate in Relation to the MTHFR (C677T) Genotype

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    Metadata for the WAGES instrumentation deployed on the RRS James Clark Ross between May 2010 and September 2013

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    The RRS James Clark Ross makes meteorological measurements around Antarctica during the austral summer, in the Arctic during the boreal summer and in the Atlantic during passages between the two poles. In May 2010, as part of the WAGES project the ships existing systems were complemented by the AutoFlux system (Yelland et al., 2009) to measure the transfers of momentum, heat and CO2 between the atmosphere and the ocean. Similarly, a commercial directional wave radar "WAVEX" made by the Norwegian firm MIROS was installed. This report describes the metadata for the WAGES instrumentation deployed on the RRS James Clark Ross between May 2010 and September 2013. Sensor serial numbers, dates of sensor changes and problems with sensors are contained in the associated tables

    Origin of the Bauschinger effect in a polycrystalline material

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    There is a long and lively debate in the literature about the origin of the Bauschinger effect in polycrystalline materials, the most widely accepted explanation being the easier movement of dislocations during reverse loading causing the reduction of the yield stress. Other explanations include incompatible deformation at the grain scale and change of dislocation cell structures during forward and reverse loading, but recent publications show these phenomenological explanations of the Bauschinger effect are not holistic. In the experimental work presented here, we have investigated the role of micro residual lattice strain on the origin of the Bauschinger effect in type 316H austenitic stainless steel using in-situ neutron diffraction. Standard cylindrical specimens were tension-compression load cycled at room temperature with the loading interrupted at incrementally larger compressive and tensile strains followed by reloading to the tensile loop peak strain. Mirror symmetric compression-tension cyclic tests were also performed with tensile and compressive load interruptions followed by compressive reloading to the compressive loop peak strain. A strong correlation is demonstrated between the evolution of residual lattice strain in the grain families and the change in magnitude in macroscopic yield stress, peak stress and the shape of the yielding part of the stress-strain curve for both the cyclic tension yield and compression yield tests. This implies that the residual lattice strain generated by grain scale elastic and plastic deformation anisotropy is the primary source of the Bauschinger kinematic hardening effect observed in type 316H austenitic stainless steel

    Cost-utility of transcatheter aortic valve implantation for inoperable patients with severe aortic stenosis treated by medical management: a UK cost-utility analysis based on patient-level data from the ADVANCE study.

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    OBJECTIVE: To use patient-level data from the ADVANCE study to evaluate the cost-effectiveness of transcatheter aortic valve implantation (TAVI) compared to medical management (MM) in patients with severe aortic stenosis from the perspective of the UK NHS. METHODS: A published decision-analytic model was adapted to include information on TAVI from the ADVANCE study. Patient-level data informed the choice as well as the form of mathematical functions that were used to model all-cause mortality, health-related quality of life and hospitalisations. TAVI-related resource use protocols were based on the ADVANCE study. MM was modelled on publicly available information from the PARTNER-B study. The outcome measures were incremental cost-effectiveness ratios (ICERs) estimated at a range of time horizons with benefits expressed as quality-adjusted life-years (QALY). Extensive sensitivity/subgroup analyses were undertaken to explore the impact of uncertainty in key clinical areas. RESULTS: Using a 5-year time horizon, the ICER for the comparison of all ADVANCE to all PARTNER-B patients was £13 943 per QALY gained. For the subset of ADVANCE patients classified as high risk (Logistic EuroSCORE >20%) the ICER was £17 718 per QALY gained). The ICER was below £30 000 per QALY gained in all sensitivity analyses relating to choice of MM data source and alternative modelling approaches for key parameters. When the time horizon was extended to 10 years, all ICERs generated in all analyses were below £20 000 per QALY gained. CONCLUSION: TAVI is highly likely to be a cost-effective treatment for patients with severe aortic stenosis

    Domains and processes for institutionalizing evidence-informed health policy-making: a critical interpretive synthesis

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    BACKGROUND: While calls for institutionalization of evidence-informed policy-making (EIP) have become stronger in recent years, there is a paucity of methods that governments and organizational knowledge brokers can use to sustain and integrate EIP as part of mainstream health policy-making. The objective of this paper was to conduct a knowledge synthesis of the published and grey literatures to develop a theoretical framework with the key features of EIP institutionalization. METHODS: We applied a critical interpretive synthesis (CIS) that allowed for a systematic, yet iterative and dynamic analysis of heterogeneous bodies of literature to develop an explanatory framework for EIP institutionalization. We used a "compass" question to create a detailed search strategy and conducted electronic searches to identify papers based on their potential relevance to EIP institutionalization. Papers were screened and extracted independently and in duplicate. A constant comparative method was applied to develop a framework on EIP institutionalization. The CIS was triangulated with the findings of stakeholder dialogues that involved civil servants, policy-makers and researchers. RESULTS: We identified 3001 references, of which 88 papers met our eligibility criteria. This CIS resulted in a definition of EIP institutionalization as the "process and outcome of (re-)creating, maintaining and reinforcing norms, regulations, and standard practices that, based on collective meaning and values, actions as well as endowment of resources, allow evidence to become-over time-a legitimate and taken-for-granted part of health policy-making". The resulting theoretical framework comprised six key domains of EIP institutionalization that capture both structure and agency: (1) governance; (2) standards and routinized processes; (3) partnership, collective action and support; (4) leadership and commitment; (5) resources; and (6) culture. Furthermore, EIP institutionalization is being achieved through five overlapping stages: (i) precipitating events; (ii) de-institutionalization; (iii) semi-institutionalization (comprising theorization and diffusion); (iv) (re)-institutionalization; and (v) renewed de-institutionalization processes. CONCLUSIONS: This CIS advances the theoretical and conceptual discussions on EIP institutionalization, and provides new insights into an evidence-informed framework for initiating, strengthening and/or assessing efforts to institutionalize EIP

    Beyond prejudice: Are negative evaluations the problem and is getting us to like one another more the solution?

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    publication-status: Acceptedtypes: ArticleThis is a post print version of an article published in Behavioral and Brain Sciences, 2012, 35 (6), pp 438-439 DOI: http://dx.doi.org/10.1017/S0140525X12001252 Copyright © Cambridge University Press 2012For most of the history of prejudice research, negativity has been treated as its emotional and cognitive signature, a conception that continues to dominate work on the topic. By this definition, prejudice occurs when we dislike or derogate members of other groups. Recent research, however, has highlighted the need for a more nuanced and ‘inclusive’ (Eagly 2004) perspective on the role of intergroup emotions and beliefs in sustaining discrimination. On the one hand, several independent lines of research have shown that unequal intergroup relations are often marked by attitudinal complexity, with positive responses such as affection and admiration mingling with negative responses such as contempt and resentment. Simple antipathy is the exception rather than the rule. On the other hand, there is mounting evidence that nurturing bonds of affection between the advantaged and the disadvantaged sometimes entrenches rather than disrupts wider patterns of discrimination. Notably, prejudice reduction interventions may have ironic effects on the political attitudes of the historically disadvantaged, decreasing their perceptions of injustice and willingness to engage in collective action to transform social inequalities. These developments raise a number of important questions. Has the time come to challenge the assumption that negative evaluations are inevitably the cognitive and affective hallmarks of discrimination? Is the orthodox concept of prejudice in danger of side-tracking, if not obstructing, progress towards social justice in a fuller sense? What are the prospects for reconciling a prejudice reduction model of change, designed to get people to like one another more, with a collective action model of change, designed to ignite struggles to achieve intergroup equality
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