413 research outputs found

    Welcoming Wellness to Your Library

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    Promoting wellness in the library is a natural extension of our roles as librarians and the role of the library in the community. Librarians have an opportunity to be role models and to exhibit the importance of making time for daily healthy habits. In this presentation, we will discuss the ways in which we have included wellness programming at an academic law library, our successes and failures, and the impact this programming has had on our law school community. Examples of our wellness programming include yoga in the library; circulating recreational equipment; magazine subscriptions; sound baths; virtual reality; jigsaw puzzles; exam period “stressbusters” like coloring pages, word searches, and games; mindfulness sessions; and therapy dogs. For each event, we will share photos and discuss time commitment, advertising, cost, engagement level, and lessons learned

    Let’s Celebrate!

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    This presentation will take you through the academic year of celebrations we plan and host at the Law Library, such as Valentine’s Day, ALA’s International Games Week, Dictionary Day, and Constitution Day. By recognizing and celebrating both major and minor holidays, we boost morale, build community, expose our students to new information, and give our patrons something to look forward to. Details on purpose, time commitment, advertising, cost, engagement level, and lessons learned will be shared

    Friedewald-Estimated Versus Directly Measured Low-Density Lipoprotein Cholesterol and Treatment Implications

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    ObjectivesThe aim of this study was to compare Friedewald-estimated and directly measured low-density lipoprotein cholesterol (LDL-C) values.BackgroundLDL-C is routinely estimated by the Friedewald equation to guide treatment; however, compatibility with direct measurement has received relatively little scrutiny, especially at levels <70 mg/dl now targeted in high-risk patients.MethodsWe examined 1,340,614 U.S. adults who underwent lipid profiling by vertical spin density gradient ultracentrifugation (Atherotech, Birmingham, Alabama) from 2009 to 2011. Following standard practice, Friedewald LDL-C was not estimated if triglyceride levels were ≥400 mg/dl (n = 30,174), yielding 1,310,440 total patients and 191,333 patients with Friedewald LDL-C <70 mg/dl.ResultsPatients were 59 ± 15 years of age and 52% were women. Lipid distributions closely matched those in the National Health and Nutrition Examination Survey. A greater difference in the Friedewald-estimated versus directly measured LDL-C occurred at lower LDL-C and higher triglyceride levels. If the Friedewald-estimated LDL-C was <70 mg/dl, the median directly measured LDL-C was 9.0 mg/dl higher (5th to 95th percentiles, 1.8 to 15.4 mg/dl) when triglyceride levels were 150 to 199 mg/dl and 18.4 mg/dl higher (5th to 95th percentiles, 6.6 to 36.0 mg/dl) when triglyceride levels were 200 to 399 mg/dl. Of patients with a Friedewald-estimated LDL-C <70 mg/dl, 23% had a directly measured LDL-C ≥70 mg/dl (39% if triglyceride levels were concurrently 150 to 199 mg/dl; 59% if triglyceride levels were concurrently 200 to 399 mg/dl).ConclusionsThe Friedewald equation tends to underestimate LDL-C most when accuracy is most crucial. Especially if triglyceride levels are ≥150 mg/dl, Friedewald estimation commonly classifies LDL-C as <70 mg/dl despite directly measured levels ≥70 mg/dl, and therefore additional evaluation is warranted in high-risk patients

    Outsiders at School: The Prevalence of Bullying and its Relation with Social Status

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    This article examines the prevalence of bullying on a group (school-class) level, the impact of data sources (self vs. other nominations) on victim identification, and the relation between bullying and rejection by peers in two samples from different types of schools (n = 930). I found that each school class typically contained one or two victims, who were best identified by peer reports, which proved to be highly consensual and distinct, and correlated closely with teacher reports. The simultaneous use of peer and self-reports allowed me to identify `defensive' as well as `sensitive' victims, i. e. individuals who were nominated via one data source only. Finally, a positive correlation between rejection and bullying was found, reflecting the fact that almost all bullied students were simultaneously rejected. In contrast, not all rejected students were victimized. That is, two subgroups of rejected individuals were identified: `Victimized-Rejected' and `Nonvictimized-Rejected'. The findings are discussed with respect to the possibility of generalizing insights from the sociometric literature to the phenomenon of bullying

    The mycobacterial glycoside hydrolase LamH enables capsular arabinomannan release and stimulates growth

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    \ua9 The Author(s) 2024.Mycobacterial glycolipids are important cell envelope structures that drive host-pathogen interactions. Arguably, the most important are lipoarabinomannan (LAM) and its precursor, lipomannan (LM), which are trafficked from the bacterium to the host via unknown mechanisms. Arabinomannan is thought to be a capsular derivative of these molecules, lacking a lipid anchor. However, the mechanism by which this material is generated has yet to be elucidated. Here, we describe the identification of a glycoside hydrolase family 76 enzyme that we term LamH (Rv0365c in Mycobacterium tuberculosis) which specifically cleaves α−1,6-mannoside linkages within LM and LAM, driving its export to the capsule releasing its phosphatidyl-myo-inositol mannoside lipid anchor. Unexpectedly, we found that the catalytic activity of this enzyme is important for efficient exit from stationary phase cultures, potentially implicating arabinomannan as a signal for growth phase transition. Finally, we demonstrate that LamH is important for M. tuberculosis survival in macrophages

    Building Partnerships to Address Social and Technological Challenges to Enhance Farm Profitability and Improve Water Quality Through Better Grassland Management

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    With 2.1 million acres of pastureland and 1.25 million acres of hay land in Virginia, the rural Virginia landscape is predominately grassland. These lands form the base of the 3.96billiondollarlivestockanddairyindustryinVirginia.Managingtheselivestockinaprofitablemannerforfarmersandbeneficialtotheenvironmentisimportant.AculturaltraditionwithrootsincolonialtimeshasbeentorunanimalsinlargefieldsyearroundthroughoutVirginia.Livestockoftengrazefromspringuntilfall(about220days),andfarmersfeedhaytheremainderoftheyear.Spikesinthecostoffuel,fertilizer,andequipmentaremakingtraditionalgrazing/hayingsystemslessprofitable.TheVirginiaCooperativeExtensionFarmEnterprisebudgetsshowthatthatthecostofhayaccountsforover503.96 billion-dollar livestock and dairy industry in Virginia. Managing these livestock in a profitable manner for farmers and beneficial to the environment is important. A cultural tradition with roots in colonial times has been to run animals in large fields year-round throughout Virginia. Livestock often graze from spring until fall (about 220 days), and farmers feed hay the remainder of the year. Spikes in the cost of fuel, fertilizer, and equipment are making traditional grazing/haying systems less profitable. The Virginia Cooperative Extension Farm Enterprise budgets show that that the cost of hay accounts for over 50% of the cost of sustaining livestock annually. University of Kentucky shows that most cow-calf producers maximize their profitability by shifting from grazing 220 days to grazing 275 to 300 days. Extension agents working with livestock producers found that they could improve their profitability by at least 75 per cow by extending their grazing season. The same phenomenon applies to other types of grazing livestock. If ten percent of the livestock producers in the state adopted better grazing management to extend their grazing season by 60 days, profitability is expected for Virginia grazing livestock producers by over $5 million per year. Practices such as rotational grazing and stream exclusion are directly tied to National and State goals to improve water quality in the Chesapeake Bay. Virginia’s Phase III WIP (Chesapeake Bay Watershed Improvement Plan) seeks the exclusion of livestock from all perennial streams and achieving good rotational grazing practices on 347,000 acres of pasture. A number of agencies and private sector groups have been providing cost share and technical guidance to incentivize livestock stream exclusion and the installation of pasture management infrastructure. Installation is only part of the challenge. Farmers also need to be taught how to how to manage the system in a profitable manner and have been slow to adopt good pasture management practices. Preliminary data show that 87% of Virginia’s cow-calf producers manage their grasslands using traditional methods. Only six percent have extended their grazing season beyond 265 days
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