424 research outputs found
Modular representation theory of BIB designs
Available online 8 November 2016Our aim is to study the modular representation theory of coherent configurations. Let p be a prime. We consider structures of modular adjacency algebras of coherent configurations obtained from combinatorial designs. The structures of standard modules of modular adjacency algebras provide more information than p-ranks of incidence matrices of combinatorial designs. (C) 2016 Elsevier Inc. All rights reserved.ArticleLINEAR ALGEBRA AND ITS APPLICATIONS. 514:174-197 (2017)journal articl
Amoxicillin-Induced Eosinophilic Pneumonia with Granulomatous Reaction: Discrepancy between Drug-Induced Lymphocyte Stimulation Test Findings and the Provocation Drug Test
<p/> <p>A 59-year-old man was admitted to the hospital with pulmonary infiltration, fever, erythema, and eosinophilia. Two weeks before admission, he received amoxicillin, acetaminophen, and shoseiryu-to (a Japanese herbal medicine) for a common cold. Bronchoalveolar lavage was performed, and an increased number of eosinophils was recovered. Transbronchial biopsy specimens showed granuloma and interstitial thickening with eosinophils and lymphocytes. Drug-induced eosinophilic pneumonia was suspected, so all drugs were discontinued. The symptoms and infiltration shadow disappeared. A drug-induced lymphocyte stimulation test (DLST) was positive for acetaminophen but not for amoxicillin. In contrast to the DLST, a provocation test revealed that amoxicillin induced the drug allergy. A very striking observation was the coexistence of pulmonary eosinophilia and granulomatous lung infiltrations. In addition, there was a discrepancy between the DLST and provocation test findings. To our knowledge, there is no previous report of drug-induced eosinophilic pneumonia with a granulomatous reaction.</p
Involvement of STAT3 in Bladder Smooth Muscle Hypertrophy Following Bladder Outlet Obstruction
We examined the involvement of the signal transducer and activator of transcription 3 (STAT3) in bladder outlet obstruction (BOO)-induced bladder smooth muscle hypertrophy using a rat in vivo and in vitro study. BOO induced increases in bladder weight and bladder smooth muscle thickness 1 week after the operation. By using antibody microarrays, 64 of 389 proteins blotted on the array met our selection criteria of an INR value between > or = 2.0 and < or = 0.5. This result revealed up-regulation of transcription factors, cell cycle regulatory proteins, apoptosis-associated proteins and so on. On the other hand, down-regulation (INR value < or = 0.5) of proteins was not found. In a profiling study, we found an increase in the expression of STAT3. A significant increase in nuclear phosphorylated STAT3 expression was confirmed in bladder smooth muscle tissue by immunohistochemistry and Western blot analysis. Cyclical stretch-relaxation (1 Hz) at 120% elongation significantly increased the expression of STAT3 and of alpha-smooth muscle actin in primary cultured bladder smooth muscle cells. Furthermore, the blockade of STAT3 expression by the transfection of STAT3 small interfering RNA (siRNA) significantly prevented the stretch-induced increase in alpha-smooth muscle actin expression. These results suggest that STAT3 has an important role in the induction of bladder smooth muscle hypertrophy
SiO Maser Survey of the Inner Bar of the Galactic Bulge
We surveyed 291 MSX/2MASS infrared objects in the 7 x 2 deg area of the
galactic center in the 43 GHz SiO J=1--0 v=1 and 2 maser lines, obtaining
accurate radial velocities of 163 detected objects. The surveyed area is the
region where the IRAS catalog is incomplete due to contamination by high source
density. The objects in the present MSX/2MASS sample were chosen to have
similar infrared characteristics to those of the previous SiO-maser-survey
samples based on the color selected IRAS sources. The sampling based on the
2MASS catalog causes a bias to the foreside objects of the bulge due to heavy
obscuration by interstellar dust; the detections are considerably leaned on the
V_{lsr}<0 side. The l--v diagram reveals two conspicuous features, which were
not present or tenuous in the previous studies: one feature indicating a linear
velocity increase with longitude with |l|<1.5 deg, which is likely associated
with the inner bar, and the other feature having considerably eccentric
velocities more than those of the normal x_1-orbit family feature. The
extinction-corrected K magnitudes (if used as a distance modulus) tend to show
a sequential deposition of these objects along the line of sight toward the
Galactic center depending on their radial velocities. The tendency that
appeared in the distance measures is consistent with the bulge-bar dynamical
model utilizing the periodic orbit families in the bar potential.Comment: Full high resolution figures available as NRO report No.638 at
http://www.nro.nao.ac.jp/library/report/list.html. PASJ 58, No. 3 (June 25
issue in press
Soluble CD26 is inversely Associated with Disease Severity in Patients with Chronic Eosinophilic Pneumonia
Backgrounds: CD26, a multifunctional T cell surface glycoprotein, is a type II transmembrane protein containing only six amino acid residues in its cytoplasmic region. In addition to its membrane form, CD26 exists in plasma in a soluble form (sCD26), which is thought to be the extracellular domain of the molecule cleaved from the cell surface. Recent studies indicated CD26 have an important role in the pathogenesis of asthma, known as Th2 like disease. The function of CD26 in the esosinophlic lung disease is not well understood.Methods: Serum sCD26 was determined by enzyme-linked Immunosorbent assay in patients with acute eosinophilic pneumonia, chronic eosinophilic pneumonia (CEP), and sarcoidosis, and in healthy volunteers, to establish its value for discriminating between disease entities and as marker of disease activity.Results: Soluble CD26 was signifi cantly reduced in CEP and was related to disease severity. In particular, sCD26 was inversely correlated with arterial oxygen tension in CEP.Conclusion: Serum levels of sCD26 might appear to be useful as a new marker of CEP disease activity
複雑先天性心疾患患者における心房細動の病因 : より良い治療戦略のために
Background: The demographics of patients with congenital heart disease (CHD) and atrial fibrillation (AF) differ significantly from the general population. The etiology and treatment strategy for AF in CHD patients have been investigated but are to date inconclusive. Methods: To determine the etiology of AF in CHD and to seek a better treatment strategy, we retrospectively evaluated the atrial overload in 42 complex CHD cases with normal atrial arrangements and AF (age 25; range, 9-66 years) and the impact of a reduction in the atrial overload on the atrial rhythm. Results: Cardiac defect diagnoses varied, with 17% of the patients having a persistent left superior vena cava (PLSVC). In regard to the volume overload, the frequencies of an overload in the right atrium (RA), left atrium (LA), or both, were 50 %, 23%, and 10%, respectively (p = 0.015). Other sustained supraventricular tachycardias were observed in 29 patients (69%) before and after the onset of AF. Among these 29 patients, 26 had intra-atrial reentrant tachycardia. Fifteen patients (36%), 10 of whom had chronic AF, died during the follow-up including 3 with arrhythmias and 10 because of heart failure. Fourteen (33%) patients had no AF at the last follow-up due to medical interventions, 8 of which underwent solely an RA-sided catheter ablation and/or surgical RA overload reduction. Conclusions: AF in complex CHD with a normal atrial arrangement correlates with a higher RA-sided overload than an LA-sided and exhibits a high incidence of PLSVCs, high comorbidity of intra-atrial reentrant tachycardias, and high mortality rate. In a substantial number of patients, RA-sided interventions were effective in controlling AF. To effectively manage AF in complex CHD it is essential to understand each individual's hemodynamics and consider hemodynamic interventions.博士(医学)・甲第853号・令和4年9月28日© 2020 Published by Elsevier Ltd on behalf of Japanese College of Cardiology
<Abstract of published report>Polar Cycloaddition of 2-Benzothiopyrylium Salts with Conjugated Dienes.
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