Can computed tomography differentiate adenocarcinoma in situ from minimally invasive adenocarcinoma?

Background: Given the subtle pathological signs of adenocarcinoma in situ (AIS) and minimally invasive adenocarcinoma (MIA), effective differentiation between the two entities is crucial. However, it is difficult to predict these conditions using preoperative computed tomography (CT) imaging. In this study, we investigated whether histological diagnosis of AIS and MIA using quantitative three-dimensional CT imaging analysis could be predicted. Methods: We retrospectively analyzed the images and histopathological findings of patients with lung cancer who were diagnosed with AIS or MIA between January 2017 and June 2018. We used Synapse Vincent (v. 4.3) (Fujifilm) software to analyze the CT attenuation values and performed a histogram analysis. Results: There were 22 patients with AIS and 22 with MIA. The ground-glass nodule (GGN) rate was significantly higher in patients with AIS (p < 0.001), whereas the solid volume (p < 0.001) and solid rate (p = 0.001) were significantly higher in those with MIA. The mean (p = 0.002) and maximum (p = 0.025) CT values were significantly higher in patients with MIA. The 25th, 50th, 75th, and 97.5th percentiles (all p < 0.05) for the CT values were significantly higher in patients with MIA. Conclusions: We demonstrated that quantitative analysis of 3D-CT imaging data using software can help distinguish AIS from MIA. These analyses are useful for guiding decision-making in the surgical management of early lung cancer, as well as subsequent follow-up

Development of cosmic x-ray polarimeter

We present a performance study of a cosmic X-ray polarimeter which is based on the photoelectric effect in gas, and sensitive to a few to 30 keV range. In our polarimeter, the key device would be the 50 μm pitch Gas Electron Multiplier (GEM). We have evaluated the modulation factor using highly polarized X-ray, provided by a synchrotron accelerator. In the analysis, we selected events by the eccentricity of the charge cloud of the photoelectron track. As a result, we obtained the relationship between the selection criteria for the eccentricity and the modulation factors; for example, when we selected the events which have their eccentricity of > 0.95, the polarimeter exhibited with the modulation factor of 0.32. In addition, we estimated the Minimum Detectable Polarization degree (MDP) of Crab Nebula with our polarimeter and found 10 ksec observation is enough to detect the polarization, if we adopt suitable X-ray mirrors

Swine influenza virus strains recognize sialylsugar chains containing the molecular species of sialic acid predominantly present in the swine tracheal epithelium

AbstractWe determined the ratio of N-glycolylneuraminic acid (Neu5Gc) to N-acetylneuraminic acid (Neu5Ac) in swine respiratory epithelia by fluorometric high-performance liquid chromatography, and examined the binding specificity of swine influenza virus strains for gangliosides containing different molecular species of sialic acid (Neu5Ac and Neu5Gc), and for bovine erythrocyte sialoglycoprotein 2 (GP-2) containing Neu5Gc as its predominate sialic acid (96% of total sialic acids). The presence of Neu5Gc, which had not been detected in human tracheal epithelia, and Neu5Ac in swine tracheal epithelia was observed in a 1:1 ratio. The swine influenza virus H1 and H3 isolates tested, except for A/swine/Iowa/15/30 (H1N1), displayed a marked binding ability for sialylsugar chains containing Neu5Gc compared with that of the human influenza virus strains. These results suggest that swine influenza viruses recognize sialylsugar chains containing the molecular species of sialic acid present predominantly in the swine tracheal epithelium.© 1997 Federation of European Biochemical Societies

Distinct connectivity patterns in human medial parietal cortices: Evidence from standardized connectivity map using cortico-cortical evoked potential

The medial parietal cortices are components of the default mode network (DMN), which are active in the resting state. The medial parietal cortices include the precuneus and the dorsal posterior cingulate cortex (dPCC). Few studies have mentioned differences in the connectivity in the medial parietal cortices, and these differences have not yet been precisely elucidated. Electrophysiological connectivity is essential for understanding cortical function or functional differences. Since little is known about electrophysiological connections from the medial parietal cortices in humans, we evaluated distinct connectivity patterns in the medial parietal cortices by constructing a standardized connectivity map using cortico-cortical evoked potential (CCEP). This study included nine patients with partial epilepsy or a brain tumor who underwent chronic intracranial electrode placement covering the medial parietal cortices. Single-pulse electrical stimuli were delivered to the medial parietal cortices (38 pairs of electrodes). Responses were standardized using the z-score of the baseline activity, and a response density map was constructed in the Montreal Neurological Institutes (MNI) space. The precuneus tended to connect with the inferior parietal lobule (IPL), the occipital cortex, superior parietal lobule (SPL), and the dorsal premotor area (PMd) (the four most active regions, in descending order), while the dPCC tended to connect to the middle cingulate cortex, SPL, precuneus, and IPL. The connectivity pattern differs significantly between the precuneus and dPCC stimulation (p<0.05). Regarding each part of the medial parietal cortices, the distributions of parts of CCEP responses resembled those of the functional connectivity database. Based on how the dPCC was connected to the medial frontal area, SPL, and IPL, its connectivity pattern could not be explained by DMN alone, but suggested a mixture of DMN and the frontoparietal cognitive network. These findings improve our understanding of the connectivity profile within the medial parietal cortices. The electrophysiological connectivity is the basis of propagation of electrical activities in patients with epilepsy. In addition, it helps us to better understand the epileptic network arising from the medial parietal cortices

The neural tides of sleep and consciousness revealed by single-pulse electrical brain stimulation

Wakefulness and sleep arise from global changes in brain physiology that may also govern the flow of neural activity between cortical regions responsible for perceptual processing vs planning and action. To test whether and how the sleep/wake cycle affects the overall propagation of neural activity in large-scale brain networks, we applied single-pulse electrical stimulation (SPES) in patients implanted with intracranial EEG electrodes for epilepsy surgery. SPES elicited cortico-cortical spectral responses at high-gamma frequencies (CCSRHG, 80-150 Hz), which indexes changes in neuronal population firing rates. Using event-related causality analysis (ERC), we found that the overall patterns of neural propagation among sites with CCSRHG were different during wakefulness and different sleep stages. For example, stimulation of frontal lobe elicited greater propagation toward parietal lobe during slow wave sleep than during wakefulness. During REM sleep, we observed a decrease in propagation within frontal lobe, and an increase in propagation within parietal lobe, elicited by frontal and parietal stimulation, respectively. These biases in the directionality of large-scale cortical network dynamics during REM sleep could potentially account for some of the unique experiential aspects of this sleep stage. Together these findings suggest that the regulation of conscious awareness and sleep is associated with differences in the balance of neural propagation across large-scale frontal-parietal networks

浄化槽処理水の間欠ばっ気運転における窒素除去効果の検討

This study was performed using the Johkasou system installed at the Gunma National College of Technology, which uses a contact aeration process to effect water treatment. This system does not have denitrification capabilities. Several intermittent aeration modes were surveyed to investigate their effects on the total nitrogen (T–N) removal performance and energy efficiency. The water temperature was significantly correlated with the decreased velocity of dissolved oxygen (DO); the decreases at 25 and 23°C were 1.4 and 1.2 mg・(L∙hr)−1, respectively. The aeration time required to achieve DO 0 mg・L−1 was more than 6 h. The time required upon restarting to reacquire the DO value observed during aeration was 30 min. It was thought that an aeration period exceeding 3 h was necessary for denitrification. Intermittent aeration times of 3 and 6 h exhibited good biochemical oxygen demand (BOD) values at more than 25°C. However, at water temperatures lower than 20°C, the effluent BOD was approximately 3 times higher, denitrification did not proceed, and the NH4-N concentration became high. The denitrification effect was not able to expect the big effect in comparison with consecutive aeration mode. As a result of this study, we concluded that the most suitable operating conditions for intermittent aeration would employ a 3 h application from December to April, and a 6 h application from May to November. The energy costs were calculated to be 1,120,000 yen∙year−1 based on the most suitable operating conditions. In comparison to the consecutive aeration mode, the energy, environmental, and cost savings with intermittent aeration were calculated to be 38,500 kWh, 15.6t-CO2, and 730,000 yen per year