12 research outputs found
Predominance of PCR-ribotypes, 018 (smz) and 369 (trf) of Clostridium difficile in Japan: a potential relationship with other global circulating strains?
Vertex‐Shared Linear Superatomic Molecules: Stepping Stones to Novel Materials Composed of Noble Metal Clusters
Extremely small metal clusters composed of noble metal atoms (M) have orbitals similar to those of atoms and therefore can be thought of as artificial atoms or superatoms. If these superatoms can be assembled into molecular analogs, it might be possible to create materials with new characteristics and properties that are different from those of existing substances. Therefore, the concept of superatomic molecules has attracted significant attention. The present review focuses on vertex‐shared linear M12n+1 superatomic molecules formed via the sharing of a single metal atom between M13 superatoms having icosahedral cores and summarizes the knowledge obtained to date in this regard. This summary discusses the most suitable ligand combinations for the synthesis of M12n+1 superatomic molecules along with the valence electron numbers, stability, optical absorption characteristics, and luminescence properties of the M12n+1 superatomic molecules fabricated to date. This information is expected to assist in the production of many M12n+1 superatomic molecules with novel structures and physicochemical properties in the future
The I2020T Leucine-rich repeat kinase 2 transgenic mouse exhibits impaired locomotive ability accompanied by dopaminergic neuron abnormalities
<p>Abstract</p> <p>Background</p> <p><it>Leucine-rich repeat kinase 2 (LRRK2)</it> is the gene responsible for autosomal-dominant Parkinson’s disease (PD), PARK8, but the mechanism by which LRRK2 mutations cause neuronal dysfunction remains unknown. In the present study, we investigated for the first time a transgenic (TG) mouse strain expressing human LRRK2 with an I2020T mutation in the kinase domain, which had been detected in the patients of the original PARK8 family.</p> <p>Results</p> <p>The TG mouse expressed I2020T LRRK2 in dopaminergic (DA) neurons of the substantia nigra, ventral tegmental area, and olfactory bulb. In both the beam test and rotarod test, the TG mice exhibited impaired locomotive ability in comparison with their non-transgenic (NTG) littermates. Although there was no obvious loss of DA neurons in either the substantia nigra or striatum, the TG brain showed several neurological abnormalities such as a reduced striatal dopamine content, fragmentation of the Golgi apparatus in DA neurons, and an increased degree of microtubule polymerization. Furthermore, the tyrosine hydroxylase-positive primary neurons derived from the TG mouse showed an increased frequency of apoptosis and had neurites with fewer branches and decreased outgrowth in comparison with those derived from the NTG controls.</p> <p>Conclusions</p> <p>The I2020T LRRK2 TG mouse exhibited impaired locomotive ability accompanied by several dopaminergic neuron abnormalities. The TG mouse should provide valuable clues to the etiology of PD caused by the LRRK2 mutation.</p
Key factors for connecting silver-based icosahedral superatoms by vertex sharing
Metal nanoclusters composed of noble elements such as gold (Au) or silver (Ag) are regarded as superatoms. In recent years, the understanding of the materials composed of superatoms, which are often called superatomic molecules, has gradually progressed for Au-based materials. However, there is still little information on Ag-based superatomic molecules. In the present study, we synthesise two di-superatomic molecules with Ag as the main constituent element and reveal the three essential conditions for the formation and isolation of a superatomic molecule comprising two Ag13-xMx structures (M = Ag or other metal; x = number of M) connected by vertex sharing. The effects of the central atom and the type of bridging halogen on the electronic structure of the resulting superatomic molecule are also clarified in detail. These findings are expected to provide clear design guidelines for the creation of superatomic molecules with various properties and functions. Icosahedron-based M-13 nanoclusters are common building blocks to produce atomically precise superatomic molecules, but our understanding of the chemistry governing the connection between icosahedral M-13 units is limited. Here, the key factors influencing the vertex sharing connection between Ag13-xMx structures are studied, and the effects of different central metal atoms and the type of bridging halogen atom are clarified
Establishment of Enzyme Immunoassay of Human Thrombomodulin in Plasma and Urine Using Monoclonal Antibodies
Pt-17 nanocluster electrocatalysts: preparation and origin of high oxygen reduction reaction activity
We recently found that [Pt-17(CO)(12)(PPh3)(8)](z) (Pt = platinum; CO = carbon monoxide; PPh3 = triphenylphosphine; z = 1+ or 2+) is a Pt nanocluster (Pt NC) that can be synthesized with atomic precision in air. The present study demonstrates that it is possible to prepare a Pt-17-supported carbon black (CB) catalyst (Pt-17/CB) with 2.1 times higher oxygen reduction reaction (ORR) activity than commercial Pt nanoparticles/CB by the adsorption of [Pt-17(CO)(12)(PPh3)(8)](z) onto CB and subsequent calcination of the catalyst. Density functional theory calculation strongly suggests that the high ORR activity of Pt-17/CB originates from the surface Pt atoms that have an electronic structure appropriate for the progress of ORR. These results are expected to provide design guidelines for the fabrication of highly active ORR catalysts using Pt NCs with a diameter of about 1 nm and thereby enabling the use of reduced amounts of Pt in polymer electrolyte fuel cells
Pt-17 nanocluster electrocatalysts: preparation and origin of high oxygen reduction reaction activity
Change over Time in the Risk of Death among Japanese COVID-19 Cases Caused by the Omicron Variant Depending on Prevalence of Sublineages
To assess temporal changes to the risk of death in COVID-19 cases caused by the Omicron variant, we calculated age-standardized case fatality rates (CFR) in patients aged ≥40 years over nine diagnostic periods (3 January to 28 August 2022) in ten Japanese prefectures (14.8 million residents). Among 552,581 study subjects, we found that there were 1836 fatalities during the isolation period (up to 28 days from date of onset). The highest age-standardized CFR (0.85%, 95% confidence interval (CI):0.78–0.92) was observed in cases diagnosed in the second 4-week period (January 31 to February 27), after which it declined significantly up to the 6th 4-week period (0.23%, 95% CI: 0.13–0.33, May 23 to June 19). The CFR then increased again but remained at 0.39% in the eighth period (July 18 to August 28). The CFR in cases with the BA.2 or BA.5 sublineages in the age range 60–80 years was significantly lower than that with BA.1 infections (60 years: 0.19%, 0.02%, 0.053%, respectively; 70 years: 0.91%, 0.33%, 0.39%; ≥80 years: 3.78%, 1.96%, 1.81%, respectively). We conclude that the risk of death in Japanese COVID-19 patients infected with Omicron variants declined through February to mid-June 2022