44 research outputs found
Deep Investigations of Outer-Rise Tsunami Characteristics Using Well-Mapped Normal Faults Along the Japan Trench
To assess the risk of tsunamis from outer-rise earthquakes, we carried out tsunami simulations using 33 simple rectangular fault models with 60° dip angles based on marine seismic observations and surveys of the Japan Trench. The largest tsunami resulting from these models, produced by a Mw 8.7 normal-faulting event on a fault 332 km long, had a maximum height of 27.0 m. We tested variations of the predictions due to the uncertainties in the assumed parameters. Because the actual dip angles of the Japan Trench outer-rise faults range from 45° to 75°, we calculated tsunamis from earthquakes on fault models with 45°, 60°, and 75° dip angles. We also tested a compound fault model with 75° dip in the upper half and 45° dip in the lower half. Rake angles were varied by ±15°. We also tested models consisting of small subfaults with dimensions of about 60 km, models using other earthquake scaling laws, models with heterogeneous slips, and models incorporating dispersive tsunami effects. Predicted tsunami heights changed by 10–15% for heterogeneous slips, up to 10% for varying dip angles, about 5–10% from considering tsunami dispersion, about 2% from varying rake angles, and about 1% from using the model with small subfaults. The use of different earthquake scaling laws changed predicted tsunami heights by about 50% on average for the 33 fault models. We emphasize that the earthquake scaling law used in tsunami predictions for outer-rise earthquakes should be chosen with great care
The Response of Blood Pressure of Men at Work to Humid Heat
The present paper described the response of blood pressure of men at work to humid heat for the purpose of determining the permissible limit of environmental heat. From the practical viewpoint of industrial health, the upper permissible limit of humid heat seemed to be 30°-31°C wet bulb temperature and yet around 90°F effective temperature
The Response of Blood Pressure in the Sitting Position to Humid Heat
The experimental study was designed to elucidate the response of blood pressure in the sitting position to humid heat for the purpose of determining the permissible limit of environmental heat. The upper permissible limit of humid heat seemed to be around 33°C wet bulb and yet around 95°F effective temperature
Coincidence analysis to search for inspiraling compact binaries using TAMA300 and LISM data
Japanese laser interferometric gravitational wave detectors, TAMA300 and
LISM, performed a coincident observation during 2001. We perform a coincidence
analysis to search for inspiraling compact binaries. The length of data used
for the coincidence analysis is 275 hours when both TAMA300 and LISM detectors
are operated simultaneously. TAMA300 and LISM data are analyzed by matched
filtering, and candidates for gravitational wave events are obtained. If there
is a true gravitational wave signal, it should appear in both data of detectors
with consistent waveforms characterized by masses of stars, amplitude of the
signal, the coalescence time and so on. We introduce a set of coincidence
conditions of the parameters, and search for coincident events. This procedure
reduces the number of fake events considerably, by a factor
compared with the number of fake events in single detector analysis. We find
that the number of events after imposing the coincidence conditions is
consistent with the number of accidental coincidences produced purely by noise.
We thus find no evidence of gravitational wave signals. We obtain an upper
limit of 0.046 /hours (CL ) to the Galactic event rate within 1kpc from
the Earth. The method used in this paper can be applied straightforwardly to
the case of coincidence observations with more than two detectors with
arbitrary arm directions.Comment: 28 pages, 17 figures, Replaced with the version to be published in
Physical Review
Results of the search for inspiraling compact star binaries from TAMA300's observation in 2000-2004
We analyze the data of TAMA300 detector to search for gravitational waves
from inspiraling compact star binaries with masses of the component stars in
the range 1-3Msolar. In this analysis, 2705 hours of data, taken during the
years 2000-2004, are used for the event search. We combine the results of
different observation runs, and obtained a single upper limit on the rate of
the coalescence of compact binaries in our Galaxy of 20 per year at a 90%
confidence level. In this upper limit, the effect of various systematic errors
such like the uncertainty of the background estimation and the calibration of
the detector's sensitivity are included.Comment: 8 pages, 4 Postscript figures, uses revtex4.sty The author list was
correcte
Observation results by the TAMA300 detector on gravitational wave bursts from stellar-core collapses
We present data-analysis schemes and results of observations with the TAMA300
gravitational-wave detector, targeting burst signals from stellar-core collapse
events. In analyses for burst gravitational waves, the detection and
fake-reduction schemes are different from well-investigated ones for a
chirp-wave analysis, because precise waveform templates are not available. We
used an excess-power filter for the extraction of gravitational-wave
candidates, and developed two methods for the reduction of fake events caused
by non-stationary noises of the detector. These analysis schemes were applied
to real data from the TAMA300 interferometric gravitational wave detector. As a
result, fake events were reduced by a factor of about 1000 in the best cases.
The resultant event candidates were interpreted from an astronomical viewpoint.
We set an upper limit of 2.2x10^3 events/sec on the burst gravitational-wave
event rate in our Galaxy with a confidence level of 90%. This work sets a
milestone and prospects on the search for burst gravitational waves, by
establishing an analysis scheme for the observation data from an
interferometric gravitational wave detector
Effects of single therapeutic doses of promethazine, fexofenadine and olopatadine on psychomotor function and histamine-induced wheal- and flare-responses: a randomized double-blind, placebo-controlled study in healthy volunteers
Since most first-generation antihistamines have undesirable sedative effects on the central nervous systems (CNS), newer (second-generation) antihistamines have been developed to improve patients’ quality of life. However, there are few reports that directly compare the antihistaminic efficacy and impairment of psychomotor functions. We designed a double-blind, placebo controlled, crossover study to concurrently compare the clinical effectiveness of promethazine, a first-generation antihistamine, and fexofenadine and olopatadine, second-generation antihistamines, by measuring their potency as peripheral inhibitors of histamine-induced wheal and flare. Further, we investigated their sedative effects on the CNS using a battery of psychomotor tests. When single therapeutic doses of fexofenadine (60 mg), olopatadine (5 mg) and promethazine (25 mg) were given in a double-blind manner to 24 healthy volunteers, all antihistamines produced a significant reduction in the wheal and flare responses induced by histamine. In the comparison among antihistamines, olopatadine showed a rapid inhibitory effect compared with fexofenadine and promethazine, and had a potent effect compared with promethazine. In a battery of psychomotor assessments using critical flicker fusion, choice reaction time, compensatory tracking, rapid visual information processing and a line analogue rating scale as a subjective assessment of sedation, promethazine significantly impaired psychomotor function. Fexofenadine and olopatadine had no significant effect in any of the psychomotor tests. Promethazine, fexofenadine and olopatadine did not affect behavioral activity, as measured by wrist actigraphy. These results suggest that olopatadine at a therapeutic dose has greater antihistaminergic activity than promethazine, and olopatadine and fexofenadine did not cause cognitive or psychomotor impairment
Stable Operation of a 300-m Laser Interferometer with Sufficient Sensitivity to Detect Gravitational-Wave Events within our Galaxy
TAMA300, an interferometric gravitational-wave detector with 300-m baseline
length, has been developed and operated with sufficient sensitivity to detect
gravitational-wave events within our galaxy and sufficient stability for
observations; the interferometer was operated for over 10 hours stably and
continuously. With a strain-equivalent noise level of , a signal-to-noise ratio (SNR) of 30 is expected for
gravitational waves generated by a coalescence of 1.4 -1.4
binary neutron stars at 10 kpc distance. %In addition, almost all noise sources
which limit the sensitivity and which %disturb the stable operation have been
identified. We evaluated the stability of the detector sensitivity with a
2-week data-taking run, collecting 160 hours of data to be analyzed in the
search for gravitational waves.Comment: 5 pages, 4 figure
Cellular irinotecan resistance in colorectal cancer and overcoming irinotecan refractoriness through various combination trials including DNA methyltransferase inhibitors: a review
Treatment with pharmacological drugs for colorectal cancer (CRC) remains unsatisfactory. A major cause of failure in pharmacotherapy is the resistance of colon cancer cells to the drugs, creating an urgent issue. In this review, we summarize previous studies on the resistance of CRC cells to irinotecan and discuss possible reasons for refractoriness. Our review presents the following five major causes of irinotecan resistance in human CRC: (1) cellular irinotecan resistance is induced mainly through the increased expression of the drug efflux transporter, ABCG2; (2) cellular irinotecan resistance is also induced in association with a nuclear receptor, pregnane/steroid X receptor (PXR/SXR), which is enriched in the CYP3A4 gene enhancer region in CRC cells by exposing the cells to SN-38; (3) irinotecan-resistant cells possess either reduced DNA topoisomerase I (Top1) expression at both the mRNA and protein levels or Top1 missense mutations; (4) alterations in the tumor microenvironment lead to drug resistance through intercellular vesicle-mediated transmission of miRNAs; and (5) CRC stem cells are the most difficult targets to successfully treat CRC. In the clinical setting, CRC gradually develops resistance to initially effective irinotecan-based therapy. To solve this problem, several clinical trials, such as irinotecan plus cetuximab vs. cetuximab monotherapy, have been conducted. Another clinical trial on irinotecan plus guadecitabine, a DNA-methyltransferase inhibitor, has also been conducted