3D virtual environments and corporate learning:An empirical investigation of benefits

Organizations invest significant resources in learning and development (L&D) to both enhance and protect their human capital. As such, they continue to search for innovative design and delivery approaches that are both cost efficient and learning effective. In this article, we consider one organization’s use of a 3D virtual environment (VE) to bring a managerial and leadership development program, informed by collaborative learning principles, to globally distributed participants. To date, there is little empirical evidence that attests to the specific learning benefits of a VE, that is, benefits that derive from distinguishing features such as presence (i.e., the sense of ‘being there’ in the VE). Given this, and drawing from prior research, we develop and empirically test a model that examines the relationships among organizational participants’ perceptions of presence, teamwork quality and outcomes. Our results provide important insights into the mechanisms underlying L&D processes and outcomes in VEs

Contribution of common and rare variants to bipolar disorder susceptibility in extended pedigrees from population isolates.

Current evidence from case/control studies indicates that genetic risk for psychiatric disorders derives primarily from numerous common variants, each with a small phenotypic impact. The literature describing apparent segregation of bipolar disorder (BP) in numerous multigenerational pedigrees suggests that, in such families, large-effect inherited variants might play a greater role. To identify roles of rare and common variants on BP, we conducted genetic analyses in 26 Colombia and Costa Rica pedigrees ascertained for bipolar disorder 1 (BP1), the most severe and heritable form of BP. In these pedigrees, we performed microarray SNP genotyping of 838 individuals and high-coverage whole-genome sequencing of 449 individuals. We compared polygenic risk scores (PRS), estimated using the latest BP1 genome-wide association study (GWAS) summary statistics, between BP1 individuals and related controls. We also evaluated whether BP1 individuals had a higher burden of rare deleterious single-nucleotide variants (SNVs) and rare copy number variants (CNVs) in a set of genes related to BP1. We found that compared with unaffected relatives, BP1 individuals had higher PRS estimated from BP1 GWAS statistics (P = 0.001 ~ 0.007) and displayed modest increase in burdens of rare deleterious SNVs (P = 0.047) and rare CNVs (P = 0.002 ~ 0.033) in genes related to BP1. We did not observe rare variants segregating in the pedigrees. These results suggest that small-to-moderate effect rare and common variants are more likely to contribute to BP1 risk in these extended pedigrees than a few large-effect rare variants

Unraveling the Temporal Fabric of Knowledge Conversion: A Model of Media Selection and Use

We draw from and extend Nonaka’s (1994) theory of knowledge creation to develop a model of media selection and use in the knowledge conversion (KC) process. KC is a process wherein an individual is affected by the experiences of another. The outcomes of KC—transferred and transformed knowledge—hinge on the development of understanding. The KC process is enabled via various communicative and non-communicative media. Because the KC process occurs over time, it possesses a temporal fabric or structure. We explore the practical realities of KC as a dynamic, time- and experience-dependent process. We consider how the temporal fabric of KC creates an evolving reciprocal relationship among perceived media utility, selection, and use of media, as well as switching and/or combining media. We propose and discuss two key factors as determinants of perceived media utility use in the KC process: (1) the temporal behavior of individuals engaged in the KC process and (2) individual and joint experience-based factors. We also discuss the role of contextual factors as antecedents. Finally, we offer and illustrate two primary temporal structures for KC media selection and use: (1) monophasic, wherein KC participants use a single medium at a time, and (2) polyphasic, wherein KC participants deploy multiple media simultaneously. We conclude with a discussion of the implications for the design of KC-enabling systems and directions for future research

Knowledge Management in Pursuit of Performance: Insights from Nortel Networks

From 1994 through 2000, Nortel Networks transformed itself from a technology-focused to an opportunity/customer-focused company. By 2000, Nortel was a profitable, innovative leader in the telecommunications industry. The change was the result of an ambitious effort to redesign its entire new product development (NPD) process such that time-to-market was significantly reduced. NPD is highly knowledge-intensive work based on the individual and collective expertise of employees. The primary focus of this case study is on Nortel’s efforts to reengineer the front-end of its NPD process and capitalize on knowledge assets. This effort was built around a process-oriented knowledge management (KM) strategy, involving a tripartite and systematic focus on process, people, and technology. Through our case analysis we develop a model of KM success by exploring Nortel’s KM strategy and the managerial, resource, and environmental factors that influenced Nortel’s success. Nortel’s experiences suggest lessons for other firms attempting to manage knowledge assets in core business processes

Contribution of common and rare variants to bipolar disorder susceptibility in extended pedigrees from population isolates.

Current evidence from case/control studies indicates that genetic risk for psychiatric disorders derives primarily from numerous common variants, each with a small phenotypic impact. The literature describing apparent segregation of bipolar disorder (BP) in numerous multigenerational pedigrees suggests that, in such families, large-effect inherited variants might play a greater role. To identify roles of rare and common variants on BP, we conducted genetic analyses in 26 Colombia and Costa Rica pedigrees ascertained for bipolar disorder 1 (BP1), the most severe and heritable form of BP. In these pedigrees, we performed microarray SNP genotyping of 838 individuals and high-coverage whole-genome sequencing of 449 individuals. We compared polygenic risk scores (PRS), estimated using the latest BP1 genome-wide association study (GWAS) summary statistics, between BP1 individuals and related controls. We also evaluated whether BP1 individuals had a higher burden of rare deleterious single-nucleotide variants (SNVs) and rare copy number variants (CNVs) in a set of genes related to BP1. We found that compared with unaffected relatives, BP1 individuals had higher PRS estimated from BP1 GWAS statistics (P = 0.001 ~ 0.007) and displayed modest increase in burdens of rare deleterious SNVs (P = 0.047) and rare CNVs (P = 0.002 ~ 0.033) in genes related to BP1. We did not observe rare variants segregating in the pedigrees. These results suggest that small-to-moderate effect rare and common variants are more likely to contribute to BP1 risk in these extended pedigrees than a few large-effect rare variants